Confidence Statements for Ordering Quantiles

This work proposes Quor, a simple yet effective nonparametric method to compare independent samples with respect to corresponding quantiles of their populations. The method is solely based on the order statistics of the samples, and independence is its only requirement. All computations are performed using exact distributions with no need for any asymptotic considerations, and yet can be run using a fast quadratic-time dynamic programming idea. Computational performance is essential in high-dimensional domains, such as gene expression data. We describe the approach and discuss on the most important assumptions, building a parallel with assumptions and properties of widely used techniques for the same problem. Experiments using real data from biomedical studies are performed to empirically compare Quor and other methods in a classification task over a selection of high-dimensional data sets

Penerapan Pasal 29 Undang-undang Nomor 42 Tahun 1999 Tentang Jaminan Fidusia Mengenai Eksekusi Objek Jaminan Kendaraan Bermotor (Studi di PT. Smart Multi Finance Cabang Malang)

Pada skripsi ini, penulis mengangkat permasalahan hukum dalam hal Penerapan Pasal 29 Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia Mengenai Eksekusi Objek Jaminan Kendaraan Bermotor Roda Dua di PT. Smart Multi Finance Cabang Malang. Pemilihan penelitian ini berdasarkan hasil temuan penulis saat melakukan pra survey di PT. Smart Multi Finance Cabang Malang yang dimana terdapat permasalahan yang bersangkutan dengan pelaksanaan eksekusi objek jaminan. Pelaksanaan eksekusi objek jaminan di PT. Smart Multi Finance Cabang Malang tidak semudah dengan apa yang diatur dalam peraturan Perundang-undangan, hal tersebut dikarenakan banyak debitor yang melakukan perbuatan-perbuatan yang dilarang dalam perjanjian pembiayaan konsumen di PT. Smart Multi Finance Cabang Malang. Dengan banyaknya debitor yang melanggar perjanjian pembiayaan konsumen ini secara langsung sangat menyulitkan pihak kreditor yaitu PT. Smart Multi Finance Cabang Malang dalam melaksanakan eksekusi objek jaminan sesuai dengan Pasal 29 Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia. Dengan adanya kesulitan-kesulitan yang dihadapi oleh PT. Smart Multi Finance Cabang Malang dalam melaksanakan eksekusi objek jaminan maka penulis tertarik untuk melakukan penelitian ini dengan tujuan mengetahui bagaimana proses penerapan Pasal 29 Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia yang dilakukan oleh PT. Smart Multi Finance Cabang Malang.Kata Kunci: Jaminan Fidusia, PT. Smart Multi Finance Cabang Malang, Eksekusi Objek Jaminan, Pasal 29 Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia

Site specific spin dynamics in BaFe2As2: tuning the ground state by orbital differentiation

The role of orbital differentiation on the emergence of superconductivity in the Fe-based superconductors remains an open question to the scientific community. In this investigation, we employ a suitable microscopic spin probe technique, namely Electron Spin Resonance (ESR), to investigate this issue on selected chemically substituted BaFe$_{2}$As$_{2}$ single crystals. As the spin-density wave (SDW) phase is suppressed, we observe a clear increase of the Fe 3$d$ bands anisotropy along with their localization at the FeAs plane. Such an increase of the planar orbital content interestingly occurs independently on the chemical substitution responsible for suppressing the SDW phase. As a consequence, the magnetic fluctuations combined with the resultant particular symmetry of the Fe 3$d$ bands are propitious ingredients to the emergence of superconductivity in this class of materials.Comment: 6 pages, 5 figure

Finite-dimensional representations of twisted hyper loop algebras

We investigate the category of finite-dimensional representations of twisted hyper loop algebras, i.e., the hyperalgebras associated to twisted loop algebras over finite-dimensional simple Lie algebras. The main results are the classification of the irreducible modules, the definition of the universal highest-weight modules, called the Weyl modules, and, under a certain mild restriction on the characteristic of the ground field, a proof that the simple modules and the Weyl modules for the twisted hyper loop algebras are isomorphic to appropriate simple and Weyl modules for the non-twisted hyper loop algebras, respectively, via restriction of the action

Assessment of inter-examiner agreement and variability in the manual classification of auditory brainstem response

Abstract Background: The analysis of the Auditory Brainstem Response (ABR) is of fundamental importance to the investigation of the auditory system behaviour, though its interpretation has a subjective nature because of the manual process employed in its study and the clinical experience required for its analysis. When analysing the ABR, clinicians are often interested in the identification of ABR signal components referred to as Jewett waves. In particular, the detection and study of the time when these waves occur (i.e., the wave latency) is a practical tool for the diagnosis of disorders affecting the auditory system. Significant differences in inter-examiner results may lead to completely distinct clinical interpretations of the state of the auditory system. In this context, the aim of this research was to evaluate the inter-examiner agreement and variability in the manual classification of ABR. Methods: A total of 160 ABR data samples were collected, for four different stimulus intensity (80dBHL, 60dBHL, 40dBHL and 20dBHL), from 10 normal-hearing subjects (5 men and 5 women, from 20 to 52 years). Four examiners with expertise in the manual classification of ABR components participated in the study. The Bland-Altman statistical method was employed for the assessment of inter-examiner agreement and variability. The mean, standard deviation and error for the bias, which is the difference between examiners’ annotations, were estimated for each pair of examiners. Scatter plots and histograms were employed for data visualization and analysis. Results: In most comparisons the differences between examiner’s annotations were below 0.1 ms, which is clinically acceptable. In four cases, it was found a large error and standard deviation (>0.1 ms) that indicate the presence of outliers and thus, discrepancies between examiners. Conclusions: Our results quantify the inter-examiner agreement and variability of the manual analysis of ABR data, and they also allows for the determination of different patterns of manual ABR analysis

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity

CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus. A series of Rimonabant/Fubinaca hybrids have been synthesized in solution as C-terminal amides, acids, methyl esters and N-methyl amides. These compounds have been studied in cannabinoid receptor binding assay and functional receptor assay in vitro, the most active among them as agonist (LONI 11) and antagonist (LONI 4) were tested in vivo to evaluate their ability to stimulate or suppress the feeding behavior after i.p. administration. For LONI 11 formalin test and tail flick tests after s.c. and i.c.v. routes respectively, were also performed in vivo with the aim to investigate the antinociceptive effect at the central or peripheral level. In the Zymosan-induced edema and hyperalgesia, LONI 11 reduced the % paw volume increase and % paw latency after s.c. administration, also suggesting a potential anti-inflammatory activity at the periphery. Keywords. Cannabinoid receptor, Rimonabant, food intake, anorexant agent, edema