Utilización de antibióticos en una farmacia comunitaria

La sociedad actual se caracteriza por una elevada intolerancia al malestar y una urgencia por solucionar molestias, incluso menores, que conduce a una demanda de utilización de los recursos disponibles, aunque no siempre se precisen, lo que influye en que el uso, entre otros, de antibióticos sea mucho mayor de lo deseable

Benchmarking a wide spectrum of metaheuristic techniques for the radio network design problem

The radio network design (RND) is an NP-hard optimization problem which consists of the maximization of the coverage of a given area while minimizing the base station deployment. Solving RND problems efficiently is relevant to many fields of application and has a direct impact in the engineering, telecommunication, scientific, and industrial areas. Numerous works can be found in the literature dealing with the RND problem, although they all suffer from the same shortfall: a noncomparable efficiency. Therefore, the aim of this paper is twofold: first, to offer a reliable RND comparison base reference in order to cover a wide algorithmic spectrum, and, second, to offer a comprehensible insight into accurate comparisons of efficiency, reliability, and swiftness of the different techniques applied to solve the RND problem. In order to achieve the first aim we propose a canonical RND problem formulation driven by two main directives: technology independence and a normalized comparison criterion. Following this, we have included an exhaustive behavior comparison between 14 different techniques. Finally, this paper indicates algorithmic trends and different patterns that can be observed through this analysis.Publicad

Late glacial-postglacial North African landscape and forestmanagement : Palynological and anthracological studies in the caves of Kaf Taht el-Ghar and El Khil (Tingitana Peninsula, Morocco)

This work presents the anthracological and archeopalynological results obtained within the project AGRIWESTMED (ERC AdG 230561), which has involved a comprehensive retrieval of archeobiological remains based on a systematic sampling strategy, beyond the recovery of the usual archeological materials. These surveys were conducted on three sites located in the North ofMorocco: the cave of Kaf Taht-el-Ghar, 8 kmsoutheast from Tetuan, and two caveswithin the El Khil complex, close to Tanger. Both plant micro- and macro-remains (charred wood) were studied through palynological and anthracological analyses, respectively. Our goal was to assess the vegetation composition of the area as well as the impact of human activities on the landscape. In Kaf Taht-el-Ghar the dynamics of vegetation and land use is recorded over the Paleolithic, Epipaleolithic, Neolithic and Historic times. Clear changes such as the demise of ancient Paleolithic pine and juniper woods during the Epipaleolithic and the subsequent spread of grasslands are shown. Other conifers like Abies pinsapo, Cedrus atlantica and Taxus baccata also disappeared from the pollen and charred wood records. In the palynological study, cereal and broad beans (Vicia faba) are already detected in the Early Neolithic, as well as a lowering of grazing pressure. Both cereal and broad beans, along with the development of grazing activities are also documented around El Khil caves since the Early Neolithic. Throughout the whole pollen and anthracological sequences a progressive retreat of the tree cover and an extensive spread of grasslands could be set as the main features of the vegetation dynamics in this area

Knowledge and Opinions of Healthcare Professionals about Thirdhand Smoke: A Multi-National, Cross-Sectional Study

There is scarce evidence on the knowledge and opinions about third-hand smoke (THS) of health care professionals. The main aim of this study was to explore the knowledge and opinions of health care professionals about THS and, secondarily, to explore the factors that are associated with this knowledge. Cross-sectional study using a snowball sample of multi-national health care professionals (n = 233). Data were obtained from an exploratory, online questionnaire. The health care professionals’ knowledge and opinions on THS were described with absolute frequency and percentage. Chi-square and Fisher-Freeman-Halton exact tests, and simple logistic regression models, were used to explore the bivariate association between the knowledge of the concept THS and sex, continent of birth, educational level, occupation, years of experience, and attitude towards smoking. Finally, a multivariable logistic regression model incorporating all the above variables was fitted. A total of 65.2% of the participants were unaware of the term THS before the study began. In the bivariate analysis, an association was found between prior knowledge of the term THS and continent of birth (p-value = 0.030) and occupation (p-value = 0.014). In the multivariable logistic regression model, a significant association was observed between prior knowledge of the concept THS and sex (p-value = 0.005), continent of birth (p-value = 0.012), and occupation (p-value = 0.001). Almost two out of three health care professionals who participated in our study did not know what THS was. Educational activities on this topic should be implemented

Revista de Vertebrados de la Estación Biológica de Doñaña

Comportamiento reproductor del camaleón común (Chamaeleo chamaeleon L.) en el sur de EspañaDistribución de los reptiles en la provincia de Granada (SE. Península Ibérica)Datos sobre la reproducción y el crecimientode Psammodromus hispanicus Fitzinger, 1826 en un medio adehesado de la España CentralVariación en la colocación y orientación del nido del Alzacola (Cercotrichas galactotes) en dos especies de árbolesOrganización de la comunidad de aves reproductora en las landas montanas del País Vasco AtlánticoEcología de una población ibérica de lobos (Canis Lupus)Etude biométrique des Crosidures (Soricidae, Insectivora) de la región de Massa (Souss, Maroe).Variación geográfica del género Eliomys en la Península IbéricaTendencias gregarias del Ciervo (Cervus elaphus) en Doñana.Data on the autumn diet of the red deer (Cervus elaphus L. 1758) in the Montes de Toledo (Central Spain)Nota sobre la coexistencia de Hyla arborea (L. 1758E Hyla meridionalis (Boettger 1874) rn rl Valle del TiétarCalendario reproductivo y tamaño de las puesta en el galápago leproso, Mauremys leprosa (Shweigger, 1812), en Doñana, HuelvaPelícola (Felicola) inaqualis Piager, 1880 (MALLOPHAGA:TRICHODECTIDAE) parásito deE Herpestes ichneumon L (CARNIVORA: HERPESTIDAE)Abundancia y amplitud de los desplazamientos de Apodemus sylvaticus en cuatro biotopos de Doñana que difieren en cobertura vegetalPeer reviewe

Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury

Chronic cholestatic damage is associated to both accumulation of cytotoxic levels of bile acids and expansion of adult hepatic progenitor cells (HPC) as part of the ductular reaction contributing to the regenerative response. Here, we report a bile acid-specific cytotoxic response in mouse HPC, which is partially impaired by EGF signaling. Additionally, we show that EGF synergizes with bile acids to trigger inflammatory signaling and NLRP3 inflammasome activation in HPC. Aiming at understanding the impact of this HPC specific response on the liver microenvironment we run a proteomic analysis of HPC secretome. Data show an enrichment in immune and TGF-beta regulators, ECM components and remodeling proteins in HPC secretome. Consistently, HPC-derived conditioned medium promotes hepatic stellate cell (HSC) activation and macrophage M1-like polarization. Strikingly, EGF and bile acids co-treatment leads to profound changes in the secretome composition, illustrated by an abolishment of HSC activating effect and by promoting macrophage M2-like polarization. Collectively, we provide new specific mechanisms behind HPC regulatory action during cholestatic liver injury, with an active role in cellular interactome and inflammatory response regulation. Moreover, findings prove a key contribution for EGFR signaling jointly with bile acids in HPC-mediated actions

Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC-induced cholestatic injury by promoting a pro-restorative inflammatory response

Despite the well-known hepatoprotective role of the epidermal growth factor receptor (EGFR) pathway upon acute damage, its specific actions during chronic liver disease, particularly cholestatic injury, remain ambiguous and unresolved. Here, we analyzed the consequences of inactivating EGFR signaling in the liver on the regenerative response following cholestatic injury. For that, transgenic mice overexpressing a dominant negative mutant human EGFR lacking tyrosine kinase activity (ΔEGFR) in albumin-positive cells were submitted to liver damage induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), an experimental model resembling human primary sclerosing cholangitis. Our results show an early activation of EGFR after 1–2 days of a DDC-supplemented diet, followed by a signaling switch-off. Furthermore, ΔEGFR mice showed less liver damage and a more efficient regeneration following DDC injury. Analysis of the mechanisms driving this effect revealed an enhanced activation of mitogenic/survival signals, AKT and ERK1/2-MAPKs, and changes in cell turnover consistent with a quicker resolution of damage in response to DDC. These changes were concomitant with profound differences in the profile of intrahepatic immune cells, consisting of a shift in the M1/M2 balance towards M2 polarity, and the Cd4/Cd8 ratio in favor of Cd4 lymphocytes, overall supporting an immune cell switch into a pro-restorative phenotype. Interestingly, ΔEGFR livers also displayed an amplified ductular reaction, with increased expression of EPCAM and an increased number of CK19-positive ductular structures in portal areas, demonstrating an overexpansion of ductular progenitor cells. In summary, our work supports the notion that hepatocyte-specific EGFR activity acts as a key player in the crosstalk between parenchymal and non-parenchymal hepatic cells, promoting the pro-inflammatory response activated during cholestatic injury and therefore contributing to the pathogenesis of cholestatic liver disease. © 2022 The Pathological Society of Great Britain and Ireland.This work was supported by the Ministry of Science,Innovation and Universities (MICIU) and AgenciaEstatal de Investigacion (AEI), Spain (co-funded byFEDER funds/Development Fund–a Way to BuildEurope): RTI2018-099098-B-100 to AS/BH andRTI2018-094052-B-100 to AMV; and the RamonAreces Foundation: 20th National Competition forScientific and Technical Research in Life and MatterScience (2020) to IF. NL and JGS were recipients ofresearch assistant contracts linked to grant SAF2015-69145-R and RTI2018-099098-B-100, respectively. CMR was the recipient of a researchcontract (PEJD-2019-POST/BMD-16090) from the Education, Universities, Research and Spokesperson Counseling of the Community of Madrid