La biblioteca es un jardín: flores japonesas sobre papel de arroz

Este texto es un capítulo del catálogo publicado para la exposición “Herbarios imaginados: entre el arte y la ciencia”, que se celebró en Madrid, en el Centro de Arte Complutense (c arte c), del 17 de enero al 31 de marzo de 2020. En el capítulo se hace una revisión de la colección de libros y estampas japonenes que se custodian en la Biblioteca de la Facultad de Bellas Artes de la UCM. Todos los documentos (791 grabados xilográficos y 30 libros) proceden de una donación que hizo el filántropo español, que residía en Estados Unidos, Juan Carlos Cebrián (1848-1935). Se pone una especial atención a la descripción de los dos ejemplares prestados para la exposición: Fukuya Kórin y Tsuda Seifu. Ambos son libros impresos en Kioto que durante el periodo Meiji fue la sede de la principal industria textil del país. Los libros son muestrarios de estampados para telas, muchos de ellos con motivos vegetales

Application of the Schmidt-hammer for relative-age dating of glacial and periglacial landforms in the Cantabrian Mountains (NW Spain)

[EN] A Schmidt hammer was applied for relative-age dating to 48 sites in 5 different massifs of the Cantabrian Mountains (NW Spain). The sample included glacial (moraines, erratics, and polished bedrock) and periglacial (rock glaciers, blockfields, and talus slopes) sites from the last glaciation to the present in different geomorphological contexts. The rebound (R) values agree with the morphostratigraphic reconstructions, showing progressively lower values for older deposits. Six stages from the Last Glacial Maximum to the present are inferred. The results differ according to the lithology: i) the quartzites showed higher R-values and very low weathering rates; ii) the granodiorites showed larger differences in R-values reflecting clearly age differences; iii) sandstones appear to be unsuitable for Schmidt hammer measurements in some areas; however, quartzite sandstones provide better results. The rock glaciers formed in different periods after deglaciation (i.e. just after the Last Glacial Maximum, Bölling/Allerød, Holocene), indicate a paraglacial dependence rather than climate-driven landforms. The sampled blockfields stabilized after the (almost) total deglaciation of the cirques, but their origin and significance in this mountainous area remain poorly understood.SIPublicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Enfermedad de Darier-White de la vulva. Presentación de una paciente

The Darier-White disease is an uncommon genodematoses, the transmisision of autosomal dominant, characterized by lesions involving papulokeratosic mucosal and nails; may appear papules on the vulva, specifically. It is believed that the disease symptoms are caused by an abnormality in the complex filamentous desmosomo-keratin. A 34 years old with histologically confirmed Darier-White disease in the vulvar skin and mucosa is presented.La enfermedad de Darier-White es una genodematosis poco frecuente, de transmisión autosómica  dominante, caracterizada por lesiones papuloqueratósicas con afectación en las mucosas y las uñas; pueden aparecer pápulas en la vulva, específicamente. Se cree que los síntomas de la enfermedad son causados por una anormalidad en el complejo filamentoso desmosomo-queratina. Se presenta una paciente de 34 años de edad con diagnóstico histológico de enfermedad de Darier-White en la piel y la mucosa vulvar

Enfermedad de Fox-Fordyce, presentación de una paciente

The Fox-Fordyce disease is a rare inflammatory disorder characterized by the appearance of pruritic follicular papules localized in distribution to areas with apocrine glands. The pathogenesis is not clearly known; it is invloved the obstruction of the apocrine excretory duct as early phenomenon in the process. It is presented a patient of 25 years with Fox-Fordyce disease confirmed histologically and a great clinically vulvar expressiveness.  La enfermedad de Fox-Fordyce es un trastorno inflamatorio poco frecuente caracterizado por la aparición de pápulas pruriginosas con distribución folicular localizadas en las áreas dotadas de glándulas apocrinas. La etiopatogenia no se conoce con claridad; se involucra la obstrucción del conducto excretor apocrino como fenómeno precoz en el proceso. Se presenta una paciente de 25 años con la enfermedad de Fox-Fordyce confirmada histológicamente y con gran expresividad clínica vulvar

Angiomiolipoma pulmonar

Los angiomiolipomas de origen pulmonar constituyen una variante muy infrecuente de los angiomiolipomas tradicionales, con la peculiaridad de poder presentar malignidad potencial. Su diagnóstico suele ser posoperatorio, puesto que este tumor simula un proceso oncoproliferativo de pulmón, tanto por la clínica como por los estudios imagenológicos.Presentamos el caso clínico de un paciente masculino de 52 años de edad con antecedente patológico personal de angioma congénito, que fue diagnosticado incidentalmente con esta patología, y que tras ser sometido a una intervención quirúrgica hace 6 meses, se encuentra asintomático y sin signos de recidiva de la enfermedad

hCLE/RTRAF-HSPC117-DDX1-FAM98B: A New Cap-Binding Complex That Activates mRNA Translation

hCLE/C14orf166/RTRAF, DDX1, and HSPC117 are components of cytoplasmic mRNA-transporting granules kinesin-associated in dendrites. They have also been found in cytoplasmic ribosome-containing RNA granules that transport specific mRNAs halted for translation until specific neuronal signals renders them accessible to the translation machinery. hCLE associates to DDX1, HSPC117, and FAM98B in HEK293T cells and all four proteins bind to cap analog-containing resins. Competition and elution experiments indicate that binding of hCLE complex to cap resins is independent of eIF4E; the cap-binding factor needed for translation. Purified hCLE free of its associated proteins binds cap with low affinity suggesting that its interacting proteins modulate its cap association. hCLE silencing reduces hCLE accumulation and that of its interacting proteins and decreases mRNA translation. hCLE-associated RNAs have been isolated and sequenced; RNAs involved in mRNA translation are specifically associated. The data suggest that RNA granules may co-transport RNAs encoding proteins involved in specific functions together with RNAs that encode proteins needed for the translation of these specific RNAs and indicate an important role for hCLE modulating mRNA translation

La experiencia internacional en los planes hidrológicos nacionales

  En muchos países ha surgido la necesidad de la planificación hidrológica tanto por problemas de cantidad como por los de calidad del agua. No obstante, esta planificación responde a distintos esquemas que se ajustan a las diferentes realidades sociales, institucionales, económicas y ambientales de los países en relación al recurso. El artículo analiza cinco planes hídricos nacionales o estatales. Son los de España, Portugal, México, California y Australia del Sur. En general, se entiende el plan estatal como el máximo exponente de la planificación hidrológica y éste abarca de forma integral todos los aspectos relacionados con la gestión de los recursos hídricos. Su importancia y trascendencia es evidente. En el momento de la publicación de este artículo el Plan Hidrológico Nacional español ha sufrido una derogación y ha sido sustituido por uno nuevo, aunque está pendiente su aprobación como ley

Mineral composition of bee pollen and its relationship with botanical origin and harvesting period

Producción CientíficaIn the present study, the mineral composition of seventy-one bee pollen samples from four different apiaries was determined by means of inductively coupled plasma-optical emission spectrometry. The results showed that there were no significant differences in relation to the overall mineral content per sample in terms of the apiary of origin or the harvesting period; the most common elements were phosphorus and potassium with concentrations ranging from 2.3 to 5.1 g/kg (dry weight). Moreover, the mineral content of the samples analyzed was similar to or higher than the recommended as well-balanced food for bees. Regarding the nutritional value for humans, bee pollen samples could be considered as a food rich in copper, iron, magnesium, manganese, and phosphorus. Finally, a canonical discriminant analysis was performed, and it was found that the apiary of origin could be distinguished by using the first three canonical functions; furthermore, over 90% of the samples could be correctly assigned to their corresponding apiary. The results were even better as regards the harvesting period, as only the first two canonical functions were sufficient to make a distinction between the different harvesting periods, resulting in a perfect match (100% of success rate).Ministerio de Economía y Competitividad (RTI2018-096268-B-100)Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (RTA 2015-00013-C03-01 and 03)FEDER and FSE (project AGRISOST-CM S2018/BAA-4330

Dopamine and α-synuclein dysfunction in Smad3 null mice

<p>Abstract</p> <p>Background</p> <p>Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Transforming growth factor-β1 (TGF-β1) levels increase in patients with PD, although the effects of this increment remain unclear. We have examined the mesostriatal system in adult mice deficient in Smad3, a molecule involved in the intracellular TGF-β1 signalling cascade.</p> <p>Results</p> <p>Striatal monoamine oxidase (MAO)-mediated dopamine (DA) catabolism to 3,4-dihydroxyphenylacetic acid (DOPAC) is strongly increased, promoting oxidative stress that is reflected by an increase in glutathione levels. Fewer astrocytes are detected in the ventral midbrain (VM) and striatal matrix, suggesting decreased trophic support to dopaminergic neurons. The SN of these mice has dopaminergic neuronal degeneration in its rostral portion, and the pro-survival Erk1/2 signalling is diminished in nigra dopaminergic neurons, not associated with alterations to p-JNK or p-p38. Furthermore, inclusions of α-synuclein are evident in selected brain areas, both in the perikaryon (SN and paralemniscal nucleus) or neurites (motor and cingulate cortices, striatum and spinal cord). Interestingly, these α-synuclein deposits are detected with ubiquitin and P^S129-α-synuclein in a core/halo cellular distribution, which resemble those observed in human Lewy bodies (LB).</p> <p>Conclusions</p> <p>Smad3 deficiency promotes strong catabolism of DA in the striatum (ST), decrease trophic and astrocytic support to dopaminergic neurons and may induce α-synuclein aggregation, which may be related to early parkinsonism. These data underline a role for Smad3 in α-synuclein and DA homeostasis, and suggest that modulatory molecules of this signalling pathway should be evaluated as possible neuroprotective agents.</p

Ancient landscape changes of mining origin in León (Spain): location and morphometric features of the Roman gold pit lakes

[ES] Las minas a cielo abierto producen cambios drásticos en el relieve y en los paisajes donde se asientan. Esos cambios dependen de la magnitud de las explotaciones, de los sistemas de explotación y del tipo de mineral extraído. Las explotaciones auríferas realizadas por los romanos en la provincia de León requirieron la movilización de grandes volúmenes de roca para extraer las bajas concentraciones de oro que contenían. Esto generó numerosos cambios en los paisajes primigenios siendo uno de ellos la aparición de lagunas mineras. Estas surgieron en minas que excavaron profundamente la superficie del terreno interceptando las aguas subterráneas que, a partir de ese momento, se acumulan en el fondo de la explotación dando lugar a la laguna. También se deben a la acumulación de escombros mineros que obturaron la escorrentía superficial de los cursos de agua. Aquellos cambios en los paisajes antiguos fueron de tal magnitud que aún hoy persisten algunas lagunas creadas por la minería aurífera romana después de dos mil años. El presente trabajo localiza y analiza los caracteres morfométricos de 12 lagunas con agua permanente que aún perduran.[EN] The open pit mines produce drastic changes in the relief and in the landscapes where they are located. These changes depend on the size of the exploitations, the exploitation systems and the type of mineral extracted. The gold mining carried out by the Romans in the province of León required the mobilization of large volumes of rock to extract the low concentrations of gold they contained, which generated great changes in the primitive landscapes, one of which is the appearance of pit lakes. The gold pit lakes appeared in mines that deeply excavated the surface of the land, intercepting the aquifer that, from that moment, accumulate at the bottom of the exploitation originating to the open pit; or they are due to the accumulation of mining dumps that blocked the surface runoff. In any case, those changes in ancient landscapes were of such magnitude that some open pits created by Roman gold mining more than two thousand years ago still persist today. The work locates and analyzes the morphometric characters of 12 pit lakes with permanent water that still exist