Is oral lornoxicam effective in the treatment of acute migraine attacks? : a randomized-controlled study

The aim of this study was to assess the efficacy of lornoxicam (LNX) in the treatment of acute migraine attacks. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial was conducted administering either LNX or placebo to patients who were diagnosed with migraine without aura according to the International Headache Society (the year 2004) criteria between 2010 and 2012 Results: Of 44 patients with 120 migraine attacks, 38 were female and rest were males. Mean age was 37.75 ± 9.28 years. Patients recorded using LNX in 87 migraine attacks and placebo in 33 migraine attacks, respectively. Pain intensity scores of the patients were found similar between LNX and placebo groups, statistically. Conclusion: Although oral LNX was found to have efficacy similar to placebo statistically in the treatment of acute migraine attacks, further studies are needed to evaluate appropriately the efficacy of LNX for treatment of acute migraine attacks

Anxiety disorders in headache patients in a specialised clinic: prevalence and symptoms in comparison to patients in a general neurological clinic

Data from several studies indicate an association of headache with anxiety disorders. In this study, we assessed and differentiated anxiety disorders in 100 headache patients by using the PSWQ (Penn State Worry Questionnaire) screening tool for generalised anxiety disorder (GAD) and the ACQ (Agoraphobic Cognitions Questionnaire) and BSQ (Body Sensation Questionnaire) for panic disorder (PD). Control groups were constructed: (1) on the basis of epidemiological studies on PD and GAD in the general population and (2) by including neurological patients. 37.0% of headache patients had a GAD. 27% of headache patients met the score for PD in the BSQ, 4.0% in the ACQ. Significant results were obtained in comparison to the general population (p < 0.001) and with regard to GAD in comparison with a sample of neurological patients (p < 0.005). The BSQ significantly correlated with the number of medication days (p < 0.005). The results confirm the increased prevalence of GAD in headache patients. PD seems to increase the risk of medication overuse

Italian guidelines for primary headaches: 2012 revised version

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version

Let's get to learn the particulate structure of matter with augmented reality!: a jigsaw IV technique lesson plan

The present study aimed to develop, introduce, and conduct an activity for the integration of augmented reality to the jigsaw IV technique in a planned and systematic manner. The activity developed for secondary school students is related to the "Pure Substances" subject which it is included in the "Particulate structure of matter" topic. The activity was arranged as; an attractive introduction, expert group studies, home team studies and assessment stages. Whereas augmented reality was used during the "home team study" stage for the jigsaw IV technique. Students are given the opportunity to examine a lot of resources during the "expert group study" and "home team study" stages to encourage them to be educated as science literate individuals. Whereas the students are subject to individual examinations during the assessment stage. This activity is an example for increasing the usage area of augmented reality in the education environment. Moreover, it is also considered that the activity will provide benefits in ensuring meaningful learning by embodying abstract concepts and helping students in improving 21st-century skills (e.g., cooperative study skills, learning to learn, communication, entrepreneurship, adaptation, leadership, social skills, and responsibility, etc.)

Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is still a poorly understood disorder which pathophysiological mechanisms include the autonomic, sensory and motor systems as well as cortical areas involved in the processing of cognitive and affective information. The main CRPS clinical symptoms are pain and hyperalgesia, vasomotor, sudomotor and trophic changes in the affected extremity. In addition, motor symptoms are usually present from the beginning, and may progress with ongoing duration. CRPS patients exhibit changes that occur in somatosensory systems processing noxious, tactile and thermal information, in sympathetic systems innervating skin (blood vessels, sweat glands) and in the somatomotor system. The most common approach to the treatment of CRPS combines sequential trials of analgesic drugs with rehabilitative and psychological interventions. Invasive techniques like sympathetic blocks, spinal cord stimulation, etc. have limited roles in CRPS. (Archives of Neuropsychiatry 2009; 46: 70-5

Palliative Care in Lung Cancer

The Lung cancer rate in all cancer types is 21% in men and 5 % in women in European Union Countries. Smoking is the most important factor of lung cancer etiology [1]. The rate of Turkey is found 63% in men and 14% in women in 1988. 88.7% of the patients in Turkey have got smoking story. Lung cancer risk increases 3.5 times in passive smoking. Because there are carcinogens in air and they are not filtered; therefore, they are denser on air [2]

Synthesis, characterization and electrical properties of iodinated poly(N-vinylimidazole)

Poly (N-vinylimidazole) was synthesized by radical polymerization. The synthesis of this conducting polymer was achieved via iodination before doping. Characterization of the product was based on elemental analysis, FT-IR spectral analysis and differential scanning calorimetry (DSC) techniques. The long-lasting conductivity of iodinated poly (N-vinylimidazole) leads us to propose that a more stable charge transfer complex was formed between the dopant and polymer. The changes in conductivity of iodinated poly(N-vinylimidazole) with time and the temperature dependence of its electrical conductivity were also studied