Assessment of sleep quality of patients with panic disorder and generalized anxiety disorder during remission: a case-control study

Background: Sleep disorders are common in psychiatric diseases. Panic disorder (PD) and generalized anxiety disorder (GAD) are two major anxiety disorders that are associated with sleep disorders. Objective: We hypothesized that poor sleep quality continues in PD and GAD during remission. Therefore, in this study we aimed to compare the sleep quality of patients with PD and GAD to that of healthy controls. Methods: The study included patients with PD (n = 42) and GAD (n = 40) who had been in remission for at least 3 months and healthy control volunteers (n = 45). The patients were administered the Pittsburgh Sleep Quality Index (PSQI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Results: The total PSQI scores of the GAD group were significantly increased in comparison to those of the PD (p = 0.009) and control (p < 0.001) groups. The rate of poor sleep quality in GAD during remission (77.5%) was greater than that of the PD (47.6%) and control (51.1%) groups (p = 0.011). Discussion: GAD is a chronic and recurrent disease. In this study, it was found that the deterioration in sleep quality of patients with GAD may continue during remission. In the follow-up and treatment of patients, it is appropriate to question about sleep symptoms and to plan interventions according to these symptoms

Chemoenzymatic synthesis of 2-brorno-6-hydroxy-3-methoxy-2-cyclohexen-1-one

WOS: 000246883000005A chemoenzymatic synthesis of 2-bromo-6-hydroxy-3-methoxy-2-cyclohexen-1-one starting from cyclohexane-1,3-dione is reported. Manganese (III) acetate-mediated acetoxylation followed by the enzyme-mediated hydrolysis of alpha'-acetoxy enone affords hydroxy-enone 5 and enone 4 with high enantiomeric excesses in good yields

Manganese(III) acetate-mediated oxidative coupling of phenylhydrazines with benzene: a novel method for biaryl coupling

The reaction of phenylhydrazines with benzene in the presence of manganese(III) acetate affords biaryls in good yields. The same reaction was carried out with similar oxidants, such as Co-III, Ce-IV and Pb-IV; among these oxidants Mn-III acetate shows higher efficiency and selectivity

ChemInform Abstract: Manganese(III) Acetate-Mediated Oxidative Coupling of Phenylhydrazines with Benzene: A Novel Method for Biaryl Coupling.

The reaction of phenylhydrazines with benzene in the presence of manganese(III) acetate affords biaryls in good yields. The same reaction was carried out with similar oxidants, such as Co-III, Ce-IV and Pb-IV; among these oxidants Mn-III acetate shows higher efficiency and selectivity

The effect of health anxiety on postoperative analgesia requirement and anesthesia recovery in patients undergoing laparoscopic cholecystectomy

Introduction: Health anxiety is the excessively negative interpretation of normal physical signs in an individual with no physical disease. Having knowledge information about the health anxiety levels of patients is one of the criteria that will affect the treatment of the patients’ pain. The aim of this study was to evaluate the preoperative health anxiety of laparoscopic cholecystectomy patients together with the perception of postoperative pain and the requirement for analgesia.Methods: The study included 41 patients of American Society of Anesthesiologists(ASA) grade I-II, aged 18-65 years who were to undergo a laparoscopic cholecystectomy operation and a control group of 40 healthy individuals. The Health Anxiety Inventory was applied to the patients preoperatively and to the control group. In the postoperative period, the patients were followed up for 24 hours with a patient-controlled analgesia device prepared with tramadol. Visuel Analog Scale(VAS) values of patients were below 4 due to the use of patient controlled analgesia device. Total analgesic consumption was recorded. The results were compared statistically.Results: No significant difference was determined between the patient and control groups in respect of age, gender and body mass index (p>0.05). The VAS score of all the patients was less than four. The mean total tramadol consumption of the patients in the first 24 hours postoperatively was 221.58±73.06. The analgesia consumption of female patients was significantly higher than that of males (p=0.013). The health anxiety results of the patient group were found to be significantly higher than the control group (p<0.001). A positive correlation was determined in the patient group between health anxiety and the total analgesia requirement (r=0.813, p<0.01). Conclusions: In conclusion, high level of analgesia consumption was determined in those with high health anxiety and in female patients. When planning postoperative pain treatment, consideration of the gender of the patient and the level of health anxiety will make a positive contribution to the treatment

Transseptal Suturing Reduce Patient Anxiety after Septoplasty Compared to Nasal Packing

Background: We measured postoperative anxiety in patients who underwent transseptal suturing or nasal packing after septoplasty. Materials and Methods: Transseptal suturing was performed on Group 1 patients and nasal splints with airway were placed after septoplasty in Group 2 patients. Postoperative 48-h anxiety levels of both groups were measured using the State-Trait Anxiety Inventory (STAI) clinical assessment scale, prior to removal of nasal packing in Group 2. Results: Transseptal suturing was performed after septoplasty in 28 patients and nasal packing in 34 patients. The State-Trait Anxiety Inventory clinical assessment state (STAI-S) and trait (STAI-T) instruments were used to measure postoperative anxiety. The STAI-S scores were found 35.00 in the transseptal suturing group and 43.8 in the nasal packing group; the difference was found significant (p 0.05). The rate of minor hemorrhage was found 10.7% in Group 1 patients. Conclusions: Transseptal suturing is simple and reliable when performed after septoplasty. The technique is painless and comfortable, and reduces patient anxiety (compared to that associated with nasal packing) with only a minor increase in operating time and hemorrhage

Clinical significance of aortic stiffness, carotid intima-media thickness and serum osteoprotegerin level in rheumatoid arthritis patients

Aim of the work: Cardiovascular diseases represent a major source of morbidity and mortality for patients with rheumatoid arthritis (RA). The increase in aortic stiffness, carotid intima-media thickness (CIMT) and serum osteoprotegerin (OPG) have been shown to be independent risk factors for cardiovascular events. This work aimed to investigate the clinical significance of these parameters in RA patients. Patients and methods: 60 RA patients and 30 control with no primary cardiovascular risk factors were included. Disease activity score (DAS28) was assessed in patients. Aortic stiffness was evaluated by transthoracic echocardiography and CIMT evaluated by Doppler ultrasonography. OPG was determined by ELISA. Results: The 60 RA patients had a mean age of 40.8 ± 8.3 years, disease duration of 6.9 ± 4.9 years and were 46 females and 14 males. In RA patients, serum OPG and CIMT (thickest and mean) were significantly higher than the control (60.5 ± 32.4 pg/ml vs 29.4 ± 16.7 pg/ml, p < 0.001; 0.73 ± 0.18 mm vs 0.63 ± 0.13 mm, p < 0.001; 0.61 ± 0.1 mm vs 0, 56 ± 0.1 mm, p = 0.007, respectively). The aortic stiffness tended to be higher in patients (6.9 ± 4.8 vs 5.2 ± 2.5, p = 0.114) and in males (9.7 ± 7.4) vs females (5.7 ± 3.4, p = 0.013). OPG levels were significantly higher in those with erosions (n = 41) (68.6 ± 34.5 pg/ml vs 49.1 ± 22 pg/ml p = 0.038) and in those seropositive (n = 54) (65.4 ± 32.2 pg/ml vs 36 ± 18.3 pg/ml p = 0.012). In patients, CIMT (thickest and mean) correlated significantly with the aortic stiffness (p = 0.02 and p = 0.04 respectively). Conclusion: RA is an independent risk factor associated with cardiovascular events. For determining this risk, measuring the serum OPG, CIMT and aortic stiffness may be a useful guide. Keywords: Aortic stiffness, Atherosclerosis, Carotid intima-media thickness, Osteoprotegerin, Rheumatoid arthritis, DAS2