The Effect of Sumatriptan in lschemic Conditions in the Rat Heart

Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection. Materials and Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters. Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p<0.05). The incidence of VT in the IPC, SUM-IR, and SUM-IPC groups was significantly lower than in the IR group (p<0.05). VF was only observed in the IR group. Conclusion: SUM protects the heart against IR injury but is not as protective as IPC alone. Although SUM diminishes IPC-induced protection against VT, the preventive effect of SUM against VF may be predictive for cardioprotection in ischemic conditions

Oral Lichen Planus: Treatment of a Refractory Case (Case Report)

Oral lichen planus (OLP) is a relatively common, chronic inflammatory disease that often affects the stratified squamous epithelia of oral mucosa. The disease is affecting approximately 1-2% of the population. It is seen mostly in the third to sixth decades of life, and is twice as common in women than men. OLP's pathogenesis of immune system is thought to have played a role in the etiology is not known. A 25-year-old male patient was referred our clinic due to white lesions on his lower lip. Similar lesions were detected on his tongue, retromolar region, gingiva as well as various parts of oral mucosa result of clinical examiation. Biopsies were taken for direct immunofluorescense (DIF) and histopathological examinations. As a result of bipsies OLP were diagnosed. In this paper the treatment of our patient and the clinical changes of patient with the treatment will be presented

The Isolated Abducens Nerve Palsy Occured After Postviral Infection in A Diabetic Patient

WOS: 000449522300015Malignancy, immunosuppressive drug use, and diabetes mellitus (DM) are defined as risk factors for herpes zoster. A 58-year-old male patient with the diagnosis of DM was admitted to the emergency room with the complaints of double vision. His neurological examination revealed under activity of the right lateral rectus muscle and hypoactive deep tendon reflexes. In this report, we discuss a rare case of isolated abducens nerve palsy that occurred after postviral infection in the patient

Bullous Dermatitis and Skin Necrosis Developing after Adrenalin Extravasation

Extravasation of vasopressors can have serious complications varying from simple local reactions to skin necrosis and compartment syndrome. Here, we presented bullous dermatitis and skin necrosis which developed due to extravasation of adrenalin infusion in a Hodgkin lymphoma patient with septic shock who was admitted due febrile neutropenia

Awareness of Migraine Among Primary Care Physicians in Turkey: A Regional Study

Introduction: Migraine is a primary headache that involves genetic and environmental factors. In studies conducted in different countries, migraine was shown to be underdiagnosed, treated insufficiently, and highly related to disability. The primary aim of this study was to identify the competence in making a diagnosis of migraine by primary care physicians who provide basic health care to patients

Extrapulmonary Features Of Bronchiectasis: Muscle Function, Exercise Capacity, Fatigue, And Health Status

Background There are limited number of studies investigating extrapulmonary manifestations of bronchiectasis. The purpose of this study was to compare peripheral muscle function, exercise capacity, fatigue, and health status between patients with bronchiectasis and healthy subjects in order to provide documented differences in these characteristics for individuals with and without bronchiectasis. Methods Twenty patients with bronchiectasis (43.5 ± 14.1 years) and 20 healthy subjects (43.0 ± 10.9 years) participated in the study. Pulmonary function, respiratory muscle strength (maximal expiratory pressure – MIP - and maximal expiratory pressure - MEP), and dyspnea perception using the Modified Medical Research Council Dyspnea Scale (MMRC) were determined. A six-minute walk test (6MWT) was performed. Quadriceps muscle, shoulder abductor, and hand grip strength (QMS, SAS, and HGS, respectively) using a hand held dynamometer and peripheral muscle endurance by a squat test were measured. Fatigue perception and health status were determined using the Fatigue Severity Scale (FSS) and the Leicester Cough Questionnaire (LCQ), respectively. Results Number of squats, 6MWT distance, and LCQ scores as well as lung function testing values and respiratory muscle strength were significantly lower and MMRC and FSS scores were significantly higher in patients with bronchiectasis than those of healthy subjects (p < 0.05). In bronchiectasis patients, QMS was significantly associated with HGS, MIP and MEP (p < 0.05). The 6MWT distance was significantly correlated to LCQ psychological score (p < 0.05). The FSS score was significantly associated with LCQ physical and total and MMRC scores (p < 0.05). The LCQ psychological score was significantly associated with MEP and 6MWT distance (p < 0.05). Conclusions Peripheral muscle endurance, exercise capacity, fatigue and health status were adversely affected by the presence of bronchiectasis. Fatigue was associated with dyspnea and health status. Respiratory muscle strength was related to peripheral muscle strength and health status, but not to fatigue, peripheral muscle endurance or exercise capacity. These findings may provide insight for outcome measures for pulmonary rehabilitation programs for patients with bronchiectasis.PubMedWoSScopu