Partisan news versus party cues: the effect of cross-cutting party and partisan network cues on polarization and persuasion

The pervasiveness of partisan media and the 24/7 news cycle allow ample opportunity for partisan-motivated reasoning and selective exposure. Nonetheless, individuals still frequently encounter out-party media outlets and expert pundits through mainstream news and social media. We seek to examine the effects of cross-cutting partisan outlet cues (e.g. Fox News, MSNBC) and direct party cues (e.g. Republican, Democrat) on citizens’ perceptions of ideology, source credibility, and news consumption. Using an experiment that pits outlet cues against direct party cues, we find that cross-cutting outlet and direct party cues lead citizens to perceive pundits as more ideologically moderate. As a result, respondents find out-party pundits on in-party outlets to be less biased, increasing interest in the pundits’ perspectives. However, while cross-cutting pundits gain among the out-party, they lose among the in-party. This trade-off holds important normative implications for individual news consumption and the ability of outlets and pundits to appear unbiased while garnering the largest possible audience

Viewed from different Engels? Differences in reactions to “socialism” as a policy label

The supposed popularity of socialism among young Americans has been a trending topic in American political media and campaigns. While evidence from public opinion polls disagrees as to whether socialism is truly gaining in popularity, the use of the term “socialism” has had a profound impact on policy discussions in the media and has featured as a prominent Republican Party strategy in the 2020 election cycle. This gives rise to important questions: How do individuals react to the socialist label? Does the socialist label serve as an ideological or affective signal? Are attacks that frame policies as socialist effective in decreasing policy support? Using original observational and experimental survey data, we find that individuals have strong polarized affective reactions to the socialist label. However, framing popular social welfare policies as socialist is ineffective in undermining popular support. Implications suggest that while framing political policies as socialist may trigger affective polarization, it is likely an ineffective means of political persuasion. As a result, oversaturation of the term in the media may lead to misleading conclusions about both political ideology and individual political behavior

Simulation of ecological impacts of the new outer-harbour development in Zeebrugge

The new outer-harbour in Zeebrugge is to be protected by jetties extending 1,750 m seaward, This development will alter the local distribution of tidal and residual currents. Such hydrodynamic changes will, in turn, affect the dispersion pattern of dissolved and particular matters in the vicinity of Zeebrugge. A mathematical model is presented, which simulates the dispersion - before and after outer harbour development - of dissolved organic matters, faecal bacteria and heavy metals, which are indicative of, respectively domestic, human, and industrial pollutions

Another exact inflationary solution

A new closed-form inflationary solution is given for a hyperbolic interaction potential. The method used to arrive at this solution is outlined as it appears possible to generate additional sets of equations which satisfy the model. In addition a new form of decaying cosmological constant is presented.Comment: 10 pages, 0 figure

Data Trends and Variability in Quality Control for Performance and Pay for Performance Specifications: Statistical Analysis

Quality assurance programs for hot-mix asphalt (HMA) have evolved from method specifications to quality assurance specifications that distribute responsibilities and risks between contractors and owners. The Illinois Department of Transportation (IDOT) developed two acceptance specifications, quality control for performance (QCP) and pay for performance (PFP), integrating contractor pay incentives and/or disincentives associated with air voids (AV), voids in mineral aggregate (VMA), and in-place density limits. A major factor that could compromise contractors’ pay in both specifications is the variability of test results due to mix production, construction, sampling, and/or inherent testing variability. Therefore, the objective of this project was to understand the distribution and variability of the test results observed under QCP and PFP specifications, as well as the potential causes of variability. The assessment approach included statistical analysis of the test results obtained for the 2015–2017 construction seasons and on-site field observations of 11 projects visited during the 2018 construction season. The pay factors of the 2015–2017 construction seasons showed contractors earned pay incentives under the PFP specification but received disincentives under QCP and PFP specifications. Contractors appeared to have more experience working with QCP projects than PFP projects. The statistical analysis identified that more than 80% of the test results between the contractor and the district were not significantly different. In those cases, it is likely that issues with mix production or construction were the reasons that led to a disincentive. However, there are possible testing issues that need to be addressed by the district and contractor such as reheating consistency and test weight control. Density was a major factor driving contractor disincentives in both specifications, followed by AV. Finally, the site visit identified mix production and construction issues that can lead to possible causes of pay disincentives, including mix switching, dust control, and aggregate contamination.IDOT-R27-189Ope

Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31

Background: Among the patients with bladder cancer, a group is still at risk of disease recurrence, progression, and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial carcinoma and is a potential therapeutic target. Objectives: To quantify tumor angiogenesis in bladder cancer and determine whether it correlates with tumor stage and grade. Patients and methods: A series of 42 archival samples from carcinomas of the urinary bladder were graded, staged, and analyzed for microvessel density (MVD) by a double immunohistochemical technique using Factor VIII (FVIII) and CD31 antibodies. The correlation between MVD and histopathological grade and tumor stage was evaluated. Results: FVIII and CD31 immunoreactivity was observed in 100% of cases and more intensely with CD31. Significantly higher MVD was determined in invasive tumors than in superficial tumors (p<0.05). MVD increased with tumor grade and stage (p<0.05); MVD was not affected by age or sex of the patients. Conclusion: These data demonstrate that MVD in bladder carcinoma correlates with the tumor grade and stage. Quantification of tumor angiogenesis may allow selection of the type of treatment for bladder cancer patients

Nonradioactive, ultrasensitive site-specific protein–protein photocrosslinking: interactions of α-helix 2 of TATA-binding protein with general transcription factor TFIIA and transcriptional repressor NC2

We have developed an approach that enables nonradioactive, ultrasensitive (attamole sensitivity) site-specific protein–protein photocrosslinking, and we have applied the approach to the analysis of interactions of α-helix 2 (H2) of human TATA-element binding protein (TBP) with general transcription factor TFIIA and transcriptional repressor NC2. We have found that TBP H2 can be crosslinked to TFIIA in the TFIIA–TBP–DNA complex and in higher order transcription–initiation complexes, and we have mapped the crosslink to the ‘connector’ region of the TFIIA α/β subunit (TFIIAα/β). We further have found that TBP H2 can be crosslinked to NC2 in the NC2–TBP–DNA complex, and we have mapped the crosslink to the C-terminal ‘tail’ of the NC2 α-subunit (NC2α). Interactions of TBP H2 with the TFIIAα/β connector and the NC2α C-terminal tail were not observed in crystal structures of TFIIA–TBP–DNA and NC2–TBP–DNA complexes, since relevant segments of TFIIA and NC2 were not present in truncated TFIIA and NC2 derivatives used for crystallization. We propose that interactions of TBP H2 with the TFIIAα/β connector and the NC2α C-terminal tail provide an explanation for genetic results suggesting importance of TBP H2 in TBP–TFIIA interactions and TBP–NC2 interactions, and provide an explanation—steric exclusion—for competition between TFIIA and NC2

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely