STRENGTH BEHAVIOUR OF CONCRETE USING FOUNDRY SAND AS AGGREGATE

The indiscriminate dumping of used foundry sand has led to environmental pollution and unwarranted occupation of space by this waste product. Since the trend all over the world now is the preservation of natural environment from pollutant. This paper has looked at the best and effective way of managing the waste foundry sand. Physical and chemical test were carried out on samples of foundry sand, to know its usefulness as alternative aggregate in concrete. Fine aggregate in concrete was partially replaced with foundry sand at 0%, 25%, 50%, 75%, and 100%. Compressive tests were carried out on sixty samples of concrete cubes of dimension 150 mm x 150 mm x 150 mm. each twelve samples was used for each aggregate composition. The pure aggregate gave a 28 days concrete strength of 20.79 N/mm2, while 25% foundry gave 19.62 N/mm2, other samples gave results that were very poor due to the presence of large clay particles. Foundry sand can be applied to fine aggregate in concrete up to 25% inclusion

Physicians and AIDS Care: Does Knowledge Influence Their Attitude and Comfort in Rendering Care?

Adequate knowledge, positive attitude, and feeling of comfort are important factors in providing compassionate care to patients. The purpose of this study was to assess physicians\u2019 knowledge, attitude and global comfort in caring for patients with AIDS (PWA), to determine the sociodemographic variables that could influence physicians\u2019 attitude and global comfort, and to identify any relationship between their knowledge, attitude and comfort. Consultants and residents (N=211) in two Nigerian teaching hospitals were surveyed using a two-part questionnaire. Part I elicited sociodemographic and previous AIDS encounter information, and Part II assessed knowledge, attitude and global comfort with AIDS patients care. Nigerian physicians showed satisfactory knowledge, but they harbored negative attitude and low level of comfort in caring for PWA. Previous AIDS care experience, age and being a consultant or a senior resident influenced attitude, while male gender and knowing someone with AIDS influenced global comfort. Knowledge is weakly but positively associated with attitude, while attitude is modestly associated with comfort. The study reinforced the need for an ongoing education focused on experiential learning, and professional socialization in order to influence physicians\u2019 attitude and enhance their feeling of comfort when caring for PWA

How Effective is the Treatment of Locally Advanced and Metastatic Breast Cancer in Developing Centres?: A Retrospective Review

BACKGROUND: The use of chemotherapy in advanced metastatic breast cancer remains a subject of controversy. The thought of MicKinnon et al (early 1950s) that the course of breast cancer was unaffected by chemotherapy has been refuted by results of treatment in the developed countries. The poor result of treatment in developing centres still compares with prechemotherapy era. Consequently, The McKinnon’s thought may still lurk. We compared the survival of chemotherapy treated with chemotherapy untreated cancer of breast patients.METHOD: Records of breast cancer patients who presented and died between January 2010 and May  2014 were reviewed. The primary outcome was overall survival. Records of patients that received  chemotherapy with or without other tumor directed specific therapy were compared with records of patients who did not receive any tumor directed therapy.RESULT: Thirty-one patients received chemotherapy while 25 patients did not. All were females, more than 90% were of the patients had advanced or metastatic disease. Treatments were not biologically  directed and treatment plans were largely compromised and suboptimal. The overall mean survival was  19.2 ±9.2 months, and the median duration was 17.5 months(range 6-44months). The overall survival  was not statistically different between the two groups (p= 0.230, unequal variance assumed). The  objective of using neoadjuvant chemotherapy for fungating lesions was not achieved.CONCLUSION: In advanced and metastatic breast cancer, outcomes of patients who receive  suboptimal regimen of cytotoxic chemotherapy do not differ from chemotherapy untreated patients.KEYWORDS: breast cancer, suboptimal treatment, untreated, chemotherap

NEWS for Africa : adaptation and reliability of a built environment questionnaire for physical activity in seven African countries

This study reports on the adaptation and test-retest reliability of the Neighborhood Environment Walkability Scale in seven sub-Saharan African countries (NEWS-Africa). The measure will be useful for surveillance of built environment conditions for planning purposes, and to evaluate physical activity and policy interventions in Africa, two effective strategies for controlling deaths from physical inactivity-related non-communicable diseases. This report includes data collection and analysis, as well as a discussion of findings

Perceived crime and traffic safety is related to physical activity among adults in Nigeria

Background: Neighborhood safety is inconsistently related to physical activity, but is seldom studied in developing countries. This study examined associations between perceived neighborhood safety and physical activity among Nigerian adults. Methods: In a cross-sectional study, accelerometer-based physical activity (MVPA), reported walking, perceived crime and traffic safety were measured in 219 Nigerian adults. Logistic regression analysis was conducted, and the odds ratio for meeting health guidelines for MVPA and walking was calculated in relation to four safety variables, after adjustment for potential confounders. Results: Sufficient MVPA was related to more perception of safety from traffic to walk (OR = 2.28, CI = 1.13-6.25) and more safety from crime at night (OR = 1.68, CI = 1.07-3.64), but with less perception of safety from crime during the day to walk (OR = 0.34, CI = 0.06- 0.91). More crime safety during the day and night were associated with more walking. Conclusions: Perceived safety from crime and traffic were associated with physical activity among Nigerian adults. These findings provide preliminary evidence on the need to provide safe traffic and crime environments that will make it easier and more likely for African adults to be physically active

Thermal Adaptation of Dihydrofolate Reductase from the Moderate ThermophileGeobacillus stearothermophilus

The thermal melting temperature of dihydrofolate reductase from Geobacillus stearothermophilus (BsDHFR) is 30 °C higher than that of its homologue from the psychrophile Moritella profunda. Additional proline residues in the loop regions of BsDHFR have been proposed to enhance the thermostability of BsDHFR, but site-directed mutagenesis studies reveal that these proline residues contribute only minimally. Instead, the high thermal stability of BsDHFR is partly due to removal of water-accessible thermolabile residues such as glutamine and methionine, which are prone to hydrolysis or oxidation at high temperatures. The extra thermostability of BsDHFR can be obtained by ligand binding, or in the presence of salts or cosolvents such as glycerol and sucrose. The sum of all these incremental factors allows BsDHFR to function efficiently in the natural habitat of G. stearothermophilus, which is characterized by temperatures that can reach 75 °C

Evaluating the groundwater potential of coastal aquifer using geoelectrical resistivity survey and porosity estimation: A case in Ota, SW Nigeria

Geoelectrical resistivity sounding surveys was carried out at two locations (A and B) in the new CanaanCity residential estate of Canaan land Ota, Ogun state in order to locate possible targets for groundwater explorations. A total of twelve (12) vertical electrical soundings were conducted using the Schlumberger array configuration. The interpretations of the VES curves revealed five to six geoelectrical layers at location A which comprises VES1-7. The geoelectric units consist of the topsoil, sandy clay, lateritic clay, confining bed (clayey sand), and main aquifer (sand). The top of the aquifer in this part of the study area is between 40 m and 83.5 m. Likewise, a total of five to seven layers of geoelectrical units were delineated at the location B portion of the study site (VES 8–12) similar to location A with an addition of the shale unit that was interpreted to be that of the Akimbo Formation of the Dahomey Basin. The depth to the top of the productive aquifer within location B is in the range of 40–112.4 m. The delineated basal shale layer is impermeable, serving as the base seal rock for the confined aquifer system. The estimated porosity values range from 28% to 74%, indicating that the highly porous aquifer system in the area is the coastal plain sands mixed with the alluvium sand of the Benin Formation of Dahomey Basin. The study revealed the complexity of the productive aquifer system in the area and its undulating topography

Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda

Dihydrofolate reductase (DHFR) is often used as a model system to study the relation between protein dynamics and catalysis. We have studied a number of variants of the cold-adapted DHFR from Moritella profunda (MpDHFR), in which the catalytically important M20 and FG loops have been altered, and present a comparison with the corresponding variants of the wellstudied DHFR from Escherichia coli (EcDHFR). Mutations in the M20 loop do not affect the actual chemical step of transfer of hydride from reduced nicotinamide adenine dinucleotide phosphate to the substrate 7,8-dihydrofolate in the catalytic cycle in either enzyme; they affect the steady state turnover rate in EcDHFR but not in MpDHFR. Mutations in the FG loop also have different effects on catalysis by the two DHFRs. Despite the two enzymes most likely sharing a common catalytic cycle at pH 7, motions of these loops, known to be important for progression through the catalytic cycle in EcDHFR, appear not to play a significant role in MpDHFR