Producers\u27 Opinions on What Makes Demonstrations Effective

Despite the widespread and long-standing use of demonstration sites in Extension, there is little empirical evidence to inform how best to design them. We report data from 513 producers in three regions of Indiana whom we surveyed about sources of information for farm management decisions, the usefulness of demonstrations, and preferences and factors that influence their attendance at demonstrations. In general, respondents had positive opinions about demonstration events and high levels of agreement regarding their usefulness. Lack of awareness of demonstrations was the greatest single factor leading to nonattendance. We provide recommendations for organizing demonstration events based on the preferences of producers we surveyed

Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice

The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine receptors in the neurobiology of mood disorders. The present study was designed to investigate the effect of sildenafil, a phosphodiesterase type 5 inhibitor which exhibits cholinomimetic properties, alone and in combination with scopolamine in the forced swim test in mice. Moreover, we assessed the ability of sildenafil to modify the antidepressant activity of two tricyclic antidepressants with distinct cholinolytic activity, amitriptyline and desipramine. Swim sessions were conducted by placing mice in glass cylinders filled with water for 6 min and the duration of behavioral immobility during the last 4 min of the test was evaluated. Locomotor activity was measured with photoresistor actimeters. To evaluate the potential pharmacokinetic interaction between amitriptyline and sildenafil, brain and serum concentrations of amitriptyline were determined by HPLC. Sildenafil (1.25–20 mg/kg) as well as scopolamine (0.5 mg/kg) and its combination with sildenafil (1.25 mg/kg) did not affect the total immobility time duration. However, joint administration of scopolamine with sildenafil at doses of 2.5 and 5 mg/kg significantly reduced immobility time as compared to control group. Moreover, co-administration of scopolamine with sildenafil at the highest dose (5 mg/kg) significantly decreased immobility time as compared to scopolamine-treated group. Sildenafil (1.25, 2.5 and 5 mg/kg) significantly enhanced the antidepressant activity of amitriptyline (5 mg/kg). No changes in anti-immobility action of desipramine (20 mg/kg) in combination with sildenafil (5, 10 and 20 mg/kg) were observed. Sildenafil did not affect amitriptyline level in both brain and serum. In conclusion, the present study suggests that sildenafil may enhance the activity of antidepressant drugs which exhibit cholinolytic activity

Multi-center Study for Correlation Between Simple Field Tests of Upper Extremity Function and Power

Multi-center Study for Correlation Between Simple Field Tests of Upper Extremity Function and Powe

The Influence of Demonstration Sites and Field Days on Adoption of Conservation Practices

For more than 100 years, demonstrations have been used by university extension programs and other conservation professionals to increase knowledge, awareness, and adoption of agricultural practices and technologies. However, there has been no systematic, empirical examination of the effect demonstrations have on adoption of agricultural innovations nor conservation practices. We examined the relationship between producer attendance at demonstration sites and field days of four conservation practices and the subsequent adoption of these practices using a mail survey (n = 513) and in-person interviews (n = 24) with agricultural producers in three regions of Indiana. Results show that there is a significant, moderate relationship between attendance and adoption of cover crops, nutrient management, and filter strips and a significant, weak relationship for two-stage ditches. Interviews with agricultural producers suggest that cover crop demonstration sites and field days allow for learning about practices from persons outside their regular social and professional network and provide tailored advice that allow producers to understand what to consider when making a decision to adopt a conservation practice. Results indicate that demonstration sites and field days do influence adoption of conservation practices; however, data do not control for the probability that those who attend are more likely to adopt regardless of attendance