Improving practical sensitivity of energy optimized wake-up receivers: proof of concept in 65nm CMOS

We present a high performance low-power digital base-band architecture, specially designed for an energy optimized duty-cycled wake-up receiver scheme. Based on a careful wake-up beacon design, a structured wake-up beacon detection technique leads to an architecture that compensates for the implementation loss of a low-power wake-up receiver front-end at low energy and area costs. Design parameters are selected by energy optimization and the architecture is easily scalable to support various network sizes. Fabricated in 65nm CMOS, the digital base-band consumes 0.9uW (V_DD=0.37V) in sub-threshold operation at 250kbps, with appropriate 97% wake-up beacon detection and 0.04% false alarm probabilities. The circuit is fully functional at a minimum V_DD of 0.23V at f_max=5kHz and 0.018uW power consumption. Based on these results we show that our digital base-band can be used as a companion to compensate for front-end implementation losses resulting from the limited wake-up receiver power budget at a negligible cost. This implies an improvement of the practical sensitivity of the wake-up receiver, compared to what is traditionally reported.Comment: Submitted to IEEE Sensors Journa

Detailed Spatially Distributed Geothermal Heat-flow Data for Modeling of Basal Temperatures and Meltwater Production Beneath the Fennoscandian Ice Sheet

Accurate modeling of ice sheets requires proper information on boundary conditions, including the geothermal heat flow (or heat-flow density (HFD)). Traditionally, one uniform HFD value is adopted for the entire modeled domain. We have calculated a distributed, high-resolution HFD dataset for an approximate core area (Sweden and Finland) of the Scandinavian ice sheet, and imbedded this within lower-resolution data published for surrounding regions. Within the Last Glacial Maximum ice margin, HFD varies with a factor of as much as 2.8 (HFD values ranging between 30 and 83mWm–2), with an average of 49mWm–2. This average value is 17% higher than 42mWm–2, a common uniform value used in ice-sheet modeling studies of Fennoscandia. Using this new distributed dataset on HFD, instead of a traditional uniform value of 42mWm–2, yields a 1.4 times larger total basal meltwater production for the last glacial cycle. Furthermore, using the new dataset in high-resolution modeling results in increased spatial thermal gradients at the bed. This enhances and introduces new local and regional effects on basal ice temperatures and melt rates. We observed significant strengthening of local ‘ice streaming’, which in one case correlates to an ice-flow event previously interpreted from geomorphology. Regional to local variations in geothermal heat flow need to be considered for proper identification and treatment of thermal and hydraulic bed conditions, most likely also when studying Laurentide, Greenland and Antarctic ice sheets

The Intuitive Cooperation Hypothesis Revisited: A Meta-analytic Examination of Effect Size and Between-study Heterogeneity

The hypothesis that intuition promotes cooperation has attracted considerable attention. Although key results in this literature have failed to replicate in pre-registered studies, recent meta-analyses report an overall effect of intuition on cooperation. We address the question with a meta-analysis of 82 cooperation experiments, spanning four different types of intuition manipulations—time pressure, cognitive load, depletion, and induction—including 29,315 participants in total. We obtain a positive overall effect of intuition on cooperation, though substantially weaker than that reported in prior meta-analyses, and between studies the effect exhibits a high degree of systematic variation. We find that this overall effect depends exclusively on the inclusion of six experiments featuring emotion-induction manipulations, which prompt participants to rely on emotion over reason when making allocation decisions. Upon excluding from the total data set experiments featuring this class of manipulations, between-study variation in the meta-analysis is reduced substantially—and we observed no statistically discernable effect of intuition on cooperation. Overall, we fail to obtain compelling evidence for the intuitive cooperation hypothesis

Protein intake during training sessions has no effect on performance and recovery during a strenuous training camp for elite cyclists

BACKGROUND: Training camps for top-class endurance athletes place high physiological demands on the body. Focus on optimizing recovery between training sessions is necessary to minimize the risk of injuries and improve adaptations to the training stimuli. Carbohydrate supplementation during sessions is generally accepted as being beneficial to aid performance and recovery, whereas the effect of protein supplementation and timing is less well understood. We studied the effects of protein ingestion during training sessions on performance and recovery of elite cyclists during a strenuous training camp. METHODS: In a randomized, double-blinded study, 18 elite cyclists consumed either a whey protein hydrolysate-carbohydrate beverage (PRO-CHO, 14 g protein/h and 69 g CHO/h) or an isocaloric carbohydrate beverage (CHO, 84 g/h) during each training session for six days (25–29 h cycling in total). Diet and training were standardized and supervised. The diet was energy balanced and contained 1.7 g protein/kg/day. A 10-s peak power test and a 5-min all-out performance test were conducted before and after the first training session and repeated at day 6 of the camp. Blood and saliva samples were collected in the morning after overnight fasting during the week and analyzed for biochemical markers of muscle damage, stress, and immune function. RESULTS: In both groups, 5-min all-out performance was reduced after the first training session and at day 6 compared to before the first training session, with no difference between groups. Peak power in the sprint test did not change significantly between tests or between groups. In addition, changes in markers for muscle damage, stress, and immune function were not significantly influenced by treatment. CONCLUSIONS: Intake of protein combined with carbohydrate during cycling at a training camp for top cyclists did not result in marked performance benefits compared to intake of carbohydrates when a recovery drink containing adequate protein and carbohydrate was ingested immediately after each training session in both groups. These findings suggest that the addition of protein to a carbohydrate supplement consumed during exercise does not improve recovery or performance in elite cyclists despite high demands of daily exhaustive sessions during a one-week training camp

Transcriptomic analysis of dead end knockout testis reveals germ cell and gonadal somatic factors in Atlantic salmon

Sustainability challenges are currently hampering an increase in salmon production. Using sterile salmon can solve problems with precocious puberty and genetic introgression from farmed escapees to wild populations. Recently sterile salmon was produced by knocking out the germ cell-specific dead end (dnd). Several approaches may be applied to inhibit Dnd function, including gene knockout, knockdown or immunization. Since it is challenging to develop a successful treatment against a gene product already existing in the body, alternative targets are being explored. Germ cells are surrounded by, and dependent on, gonadal somatic cells. Targeting genes essential for the survival of gonadal somatic cells may be good alternative targets for sterility treatments. Our aim was to identify and characterize novel germ cell and gonadal somatic factors in Atlantic salmon.publishedVersio

Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon

-Introgression of farmed salmon escapees into wild stocks is a major threat to the genetic integrity of wild populations. Using germ cell-free fish in aquaculture may mitigate this problem. Our study investigated whether it is possible to produce germ cell-free salmon in F0 by using CRISPR-Cas9 to knock out dnd, a factor required for germ cell survival in vertebrates. To avoid studying mosaic animals, sgRNA targeting alb was simultaneously used as a visual tracer since the phenotype of alb KO is complete loss of pigmentation. Induced mutations for the tracer (alb) and the target (dnd) genes were highly correlated and produced germ cell-less fish lacking pigmentation, underlining the suitability of alb KO to serve as tracer for targeted double allelic mutations in F0 animals in species with prohibitively long generation times. This is also the first report describing dnd knockout in any fish species. Analyzing gene expression and histology of dnd KO fish revealed that sex differentiation of the somatic compartment does not depend on the presence of germ cells. However, the organization of the ovarian somatic compartment seems compromised in mutant fish