Exhaust particle number of a non-road diesel engine fuelled by methyl esters with different fatty acid compositions

ArticleThe main aim of this study was to find out how methyl esters with different fatty acid compositions affect the exhaust particle numbers. Along with fossil diesel fuel oil (DFO) and renewable diesel (HVO), a high-speed non-road diesel engine was fuelled by rapeseed (RME) and soybean (SME) methyl esters. Particle numbers within the size range of 5.6–560 nm were measured by means of an engine exhaust particle sizer (EEPS). The exhaust smoke, gaseous emissions and the basic engine performance were also determined. During the measurements, the 4-cylinder, turbocharged, intercooled engine was run according to the non-road steady cycle. Methyl esters reduced particles within the size range of 70 to 200 nm. For RME and SME, both positive and significant correlations were found between the sum of the particle numbers detected above the size category of 23 nm and methyl palmitate (C16:0), methyl stearate (C18:0) and methyl linoleate (C18:2) contents at 10% load at rated speed. In terms of nitrogen oxide (NOx) and hydrocarbon (HC) emissions, HVO was beneficial while carbon monoxide (CO) emission was the lowest with DFO. The level in smoke emission was negligible

Exhaust particle size distributions of a non-road diesel engine in an endurance test

The main objective of this study was to find out how the non-road diesel engine running period of 500 hours affects the exhaust particle size distribution. By means of an engine exhaust particle sizer (EEPS), particle number was measured before the endurance test and after 250 and 500 hours of engine operation. The size distributions were determined at full and 75% loads both at rated and at intermediate speeds. The soot, gaseous emissions and the basic engine performance were also determined and lubricating oil was analysed a few times during the running period. A blend of low-sulphur fossil diesel and soybean methyl ester (B20) was used as fuel in the 4-cylinder, turbocharged, intercooled engine which was equipped with a diesel oxidation catalyst (DOC) and a selective catalytic reduction (SCR) system. All emissions were measured downstream the catalysts. During the 500 hours of operation, the particle number increased considerably within an approximate size range of 7 to 30 nm. Between the initial and final measurements, no notable differences were observed in the particle number emissions within a particle size range of 50 to 200 nm. The copper content of lubricating oil also increased significantly during the 500 hours’ experiment. One possible reason for the substantial increase in the nucleation mode particle number was assumed to be copper, which is one of the metallic elements originating from engine wear. The engine efficiency was almost equal, and the differences both in smoke and hydrocarbon emission were negligible throughout the 500 hours’ experiment.fi=vertaisarvioitu|en=peerReviewed

Waste fish oil as an alternative renewable fuel for IC engines

Received: January 31st, 2021 ; Accepted: April 10th, 2021 ; Published: April 30th, 2021 ; Correspondence: [email protected] are potential fuels for internal combustion engines because of they have advantageous properties such as biodegradability, renewability, high oxygen content and low sulphur. However, the high viscosity, surface tension, and density of crude bio-oils pose challenges for engine use. Those properties affect fuel spray characteristics, mixture formation and combustion. In turn, these impact engine, efficiency, power and emissions. This study investigated the use of crude fish oil (FO) at medium and low engine-loads at two engine speeds in an off-road engine. The injectors had 6-hole high flow rate tips. The results were compared with those of fossil diesel fuel oil (DFO). Fish oil increased hydrocarbon (HC), carbon monoxide (CO) and partly oxides of nitrogen (NOx) emissions. Smoke number, however, decreased. Crude fish oil also showed lowered total particle number (TPN) at low load at low engine-speed compared with DFO

Associations of cognitive reserve and psychological resilience with cognitive functioning in subjects with cerebral white matter hyperintensities

Background and purpose Cerebral small vessel disease is characterized by progressive white matter hyperintensities (WMH) and cognitive decline. However, variability exists in how individuals maintain cognitive capabilities despite significant neuropathology. The relationships between individual cognitive reserve, psychological resilience and cognitive functioning were examined in subjects with varying degrees of WMH. Methods In the Helsinki Small Vessel Disease Study, 152 subjects (aged 65-75 years) underwent a comprehensive neuropsychological assessment, evaluation of subjective cognitive complaints and brain magnetic resonance imaging with volumetric WMH evaluation. Cognitive reserve was determined by education (years) and the modified Cognitive Reserve Scale (mCRS). Psychological resilience was evaluated with the Resilience Scale 14. Results The mCRS total score correlated significantly with years of education (r = 0.23, p < 0.01), but it was not related to age, sex or WMH volume. Together, mCRS score and education were associated with performance in a wide range of cognitive domains including processing speed, executive functions, working memory, verbal memory, visuospatial perception and verbal reasoning. Independently of education, the mCRS score had incremental predictive value on delayed verbal recall and subjective cognitive complaints. Psychological resilience was not significantly related to age, education, sex, WMH severity or cognitive test scores, but it was associated with subjective cognitive complaints. Conclusions Cognitive reserve has strong and consistent associations with cognitive functioning in subjects with WMH. Education is widely associated with objective cognitive functioning, whereas lifetime engagement in cognitively stimulating leisure activities (mCRS) has independent predictive value on memory performance and subjective cognitive complaints. Psychological resilience is strongly associated with subjective, but not objective, cognitive functioning.Peer reviewe

Design, development, and verification of the Planck Low Frequency Instrument 70 GHz Front-End and Back-End Modules

Peer reviewe

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression utilizing an algorithm, MutSigCV. Somatic point mutation data from the exome kit-targeted area from 24 exome-sequenced sporadic MSI CRCs and respective normals, and 12 whole-genome-sequenced sporadic MSI CRCs and respective normals were utilized. The top 73 genes were validated in 93 additional MSI CRCs. The MutSigCV ranking identified several well-established MSI CRC driver genes and provided additional evidence for previously proposed CRC candidate genes as well as shortlisted genes that have to our knowledge not been linked to CRC before. Two genes, SMARCB1 and STK38L, were also functionally scrutinized, providing evidence of a tumorigenic role, for SMARCB1 mutations in particular. © 2018 The Authors. Published under the terms of the CC BY 4.0 licensePeer reviewe

Greasing the wheels? The impact of regulations and corruption on firm entry

This paper investigates the question of whether corruption might ‘grease the wheels’ of an economy. We investigate whether and to what extent the impact of regulations on entrepreneurship is dependent on corruption. We first test whether regulations robustly deter firm entry into markets. Our results show that the existence of a larger number of procedures required to start a business, as well as larger minimum capital requirements are detrimental to entrepreneurship. Second, we test whether corruption reduces the negative impact of regulations on entrepreneurship in highly regulated economies. Our empirical analysis, covering a maximum of 43 countries over the 2003–2005 period, shows that corruption facilitates firm entry in highly regulated economies. For example, the ‘greasing’ effect of corruption kicks in at around 50 days required to start a new business. Our results thus provide support for the ‘grease the wheels’ hypothesis

Anduril 2: Upgraded large-scale data integration framework

aSummary: Anduril is an analysis and integration framework that facilitates the design, use, parallelization and reproducibility of bioinformatics workflows. Anduril has been upgraded to use Scala for pipeline construction, which simplifies software maintenance, and facilitates design of complex pipelines. Additionally, Anduril's bioinformatics repository has been expanded with multiple components, and tutorial pipelines, for next-generation sequencing data analysis.Peer reviewe

Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme

Background: Coordinated efforts to collect large-scale data sets provide a basis for systems level understanding of complex diseases. In order to translate these fragmented and heterogeneous data sets into knowledge and medical benefits, advanced computational methods for data analysis, integration and visualization are needed.Methods: We introduce a novel data integration framework, Anduril, for translating fragmented large-scale data into testable predictions. The Anduril framework allows rapid integration of heterogeneous data with state-of-the-art computational methods and existing knowledge in bio-databases. Anduril automatically generates thorough summary reports and a website that shows the most relevant features of each gene at a glance, allows sorting of data based on different parameters, and provides direct links to more detailed data on genes, transcripts or genomic regions. Anduril is open-source; all methods and documentation are freely available.Results: We have integrated multidimensional molecular and clinical data from 338 subjects having glioblastoma multiforme, one of the deadliest and most poorly understood cancers, using Anduril. The central objective of our approach is to identify genetic loci and genes that have significant survival effect. Our results suggest several novel genetic alterations linked to glioblastoma multiforme progression and, more specifically, reveal Moesin as a novel glioblastoma multiforme-associated gene that has a strong survival effect and whose depletion in vitro significantly inhibited cell proliferation. All analysis results are available as a comprehensive website.Conclusions: Our results demonstrate that integrated analysis and visualization of multidimensional and heterogeneous data by Anduril enables drawing conclusions on functional consequences of large-scale molecular data. Many of the identified genetic loci and genes having significant survival effect have not been reported earlier in the context of glioblastoma multiforme. Thus, in addition to generally applicable novel methodology, our results provide several glioblastoma multiforme candidate genes for further studies. Anduril is available at http://csbi.ltdk.helsinki.fi/anduril/ The glioblastoma multiforme analysis results are available at http://csbi.ltdk.helsinki.fi/anduril/tcga-gbm

Follow-up of patients with curatively resected colorectal cancer: a practice guideline

BACKGROUND: A systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations were developed. METHODS: The MEDLINE, CANCERLIT, and Cochrane Library databases, and abstracts published in the 1997 to 2002 proceedings of the annual meeting of the American Society of Clinical Oncology were systematically searched for evidence. Study selection was limited to randomized trials and meta-analyses that examined different programs of follow-up after curative resection of colorectal cancer where five-year overall survival was reported. External review by Ontario practitioners was obtained through a mailed survey. Final approval of the practice guideline report was obtained from the Practice Guidelines Coordinating Committee. RESULTS: Six randomized trials and two published meta-analyses of follow-up were obtained. Of six randomized trials comparing one follow-up program to a more intense program, only two individual trials detected a statistically significant survival benefit favouring the more intense follow-up program. Pooling of all six randomized trials demonstrated a significant improvement in survival favouring more intense follow-up (Relative Risk Ratio 0.80 (95%CI, 0.70 to 0.91; p = 0.0008). Although the rate of recurrence was similar in both of the follow-up groups compared, asymptomatic recurrences and re-operations for cure of recurrences were more common in patients with more intensive follow-up. Trials including CEA monitoring and liver imaging also had significant results, whereas trials not including these tests did not. CONCLUSION: Follow-up programs for patients with curatively resected colorectal cancer do improve survival. These follow-up programs include frequent visits and performance of blood CEA, chest x-rays, liver imaging and colonoscopy, however, it is not clear which tests or frequency of visits is optimal. There is a suggestion that improved survival is due to diagnosis of recurrence at an earlier, asymptomatic stage which allows for more curative resection of recurrence. Based on this evidence and consideration of the biology of colorectal cancer and present practices, a guideline was developed. Patients should be made aware of the risk of disease recurrence or second bowel cancer, the potential benefits of follow-up and the uncertainties requiring further clinical trials. For patients at high-risk of recurrence (stages IIb and III) clinical assessment is recommended when symptoms occur or at least every 6 months the first 3 years and yearly for at least 5 years. At the time of those visits, patients may have blood CEA, chest x-ray and liver imaging. For patients at lower risk of recurrence (stages I and Ia) or those with co-morbidities impairing future surgery, only visits yearly or when symptoms occur. All patients should have a colonoscopy before or within 6 months of initial surgery, and repeated yearly if villous or tubular adenomas >1 cm are found; otherwise repeat every 3 to 5 years. All patients having recurrences should be assessed by a multidisciplinary team in a cancer centre