Needle-free injection into skin and soft matter with highly focused microjets

The development of needle-free drug injection systems is of great importance to global healthcare. However, in spite of its great potential and research history over many decades, these systems are not commonly used. One of the main problems is that existing methods use diffusive jets, which result in scattered penetration and severe deceleration of the jets, causing frequent pain and insufficient penetration. Another longstanding challenge is the development of accurate small volume injections. In this paper we employ a novel method of needle-free drug injection, using highly-focused high speed microjets, which aims to solve these challenges. We experimentally demonstrate that these unique jets are able to penetrate human skin: the focused nature of these microjets creates an injection spot smaller than a mosquito's proboscis and guarantees a high percentage of the liquid being injected. The liquid substances can be delivered to a much larger depth than conventional methods, and create a well-controlled dispersion pattern. Thanks to the excellent controllability of the microjet, small volume injections become feasible. Furthermore, the penetration dynamics is studied through experiments performed on gelatin mixtures (human soft tissue equivalent) and human skin, agreeing well with a viscous stress model which we develop. This model predicts the depth of the penetration into both human skin and soft tissue. The results presented here take needle-free injections a step closer to widespread use

System configuration, fault detection, location, isolation and restoration: a review on LVDC Microgrid protections

Low voltage direct current (LVDC) distribution has gained the significant interest of research due to the advancements in power conversion technologies. However, the use of converters has given rise to several technical issues regarding their protections and controls of such devices under faulty conditions. Post-fault behaviour of converter-fed LVDC system involves both active converter control and passive circuit transient of similar time scale, which makes the protection for LVDC distribution significantly different and more challenging than low voltage AC. These protection and operational issues have handicapped the practical applications of DC distribution. This paper presents state-of-the-art protection schemes developed for DC Microgrids. With a close look at practical limitations such as the dependency on modelling accuracy, requirement on communications and so forth, a comprehensive evaluation is carried out on those system approaches in terms of system configurations， fault detection, location, isolation and restoration

Highly focused supersonic microjets

The paper describes the production of thin, focused microjets with velocities up to 850 m/s by the rapid vaporization of a small mass of liquid in an open liquid-filled capillary. The vaporization is caused by the absorption of a low-energy laser pulse. A likely explanation of the observed phenomenon is based on the impingement of the shock wave caused by the nearly-instantaneous vaporization on the free surface of the liquid. An experimental study of the dependence of the jet velocity on several parameters is conducted, and a semi-empirical relation for its prediction is developed. The coherence of the jets, their high velocity and good reproducibility and controllability are unique features of the system described. A possible application is to the development of needle-free drug injection systems which are of great importance for global health care.Comment: 10 pages, 11figure

Highly focused supersonic microjets

The paper describes the production of thin, focused microjets with velocities up to 850 m/s by the rapid vaporization of a small mass of liquid in an open liquid-filled capillary. The vaporization is caused by the absorption of a low-energy laser pulse. A likely explanation of the observed phenomenon is based on the impingement of the shock wave caused by the nearly-instantaneous vaporization on the free surface of the liquid. An experimental study of the dependence of the jet velocity on several parameters is conducted, and a semi-empirical relation for its prediction is developed. The coherence of the jets, their high velocity and good reproducibility and controllability are unique features of the system described. A possible application is to the development of needle-free drug injection systems which are of great importance for global health care.Comment: 10 pages, 11figure

Highly focused supersonic microjets: numerical simulations

By focusing a laser pulse inside a capillary partially filled with liquid, a vapour bubble is created that emits a pressure wave. This pressure wave travels through the liquid and creates a fast, focused axisymmetric microjet when it is reflected at the meniscus. We numerically investigate the formation of this microjet using axisymmetric boundary integral simulations, where we model the pressure wave as a pressure pulse applied on the bubble. We find a good agreement between the simulations and experimental results in terms of the time evolution of the jet and on all parameters that can be compared directly. We present a simple analytical model that accurately predicts the velocity of the jet after the pressure pulse and its maximum velocit

Highly focused supersonic microjets: numerical simulations

By focusing a laser pulse inside a capillary partially filled with liquid, a vapour bubble is created which emits a pressure wave. This pressure wave travels through the liquid and creates a fast, focused axisymmetric microjet when it is reflected at the meniscus. We numerically investigate the formation of this microjet using axisymmetric boundaryintegral simulations, where we model the pressure wave as a pressure pulse applied on the bubble. We find a good agreement between the simulations and experimental results in terms of the time evolution of the jet and on all parameters that can be compared directly. We present a simple analytical model that accurately predicts the velocity of the jet after the pressure pulse and its maximum velocity

Lighting the World: the first application of an open source, spatial electrification tool (OnSSET) on Sub-Saharan Africa

In September 2015, the United Nations General Assembly adopted Agenda 2030, which comprises a set of 17 Sustainable Development Goals (SDGs) defined by 169 targets. 'Ensuring access to affordable, reliable, sustainable and modern energy for all by 2030' is the seventh goal (SDG7). While access to energy refers to more than electricity, the latter is the central focus of this work. According to the World Bank's 2015 Global Tracking Framework, roughly 15% of the world's population (or 1.1 billion people) lack access to electricity, and many more rely on poor quality electricity services. The majority of those without access (87%) reside in rural areas. This paper presents results of a geographic information systems approach coupled with open access data. We present least-cost electrification strategies on a country-by-country basis for Sub-Saharan Africa. The electrification options include grid extension, mini-grid and stand-alone systems for rural, peri-urban, and urban contexts across the economy. At low levels of electricity demand there is a strong penetration of standalone technologies. However, higher electricity demand levels move the favourable electrification option from stand-alone systems to mini grid and to grid extensions

Flow batteries for energy management : novel algebraic modelling approaches to properly assess their value

Redox Flow Battery (RFB) systems are promising technologies for the multi-hour electrical energy storage that will be necessary for on-demand electricity supply based on wind and solar power. Deriving maximum value from a RFB requires optimisation of both the system design and its operation. In this work three novel algebraic modelling approaches are introduced to represent RFB operation more accurately while maintaining quick optimisation times. First the typical linear programming (LP) optimisation problem is re-posed in terms of current-density rather than power, allowing voltaic losses to be expressed as a quadratic function (QP). Secondly, it is then shown that the current-density framework supports a novel constraint for the avoidance of high cell voltage that may damage the stack. Thirdly, for the first time a binary variable (MIQP) to describe active/idle states is introduced. This allows coulombic leakage and pumping losses to be modelled as fixed terms without constantly draining the RFB, and it allows for the optimisation of pump rating in a VRFB. In a day-ahead energy management case study, it is found that the QP optimisation predicts an additional 19 % annual revenue when compared to the LP optimisation. This capture of the true flexibility of the RFB operation allows its full value to be assessed, and therefore advances the case for their deployment within the energy system. Furthermore, the formulations developed are not only applicable to RFBs but to the scheduling of other battery systems, particularly Li-ion, and balance of plant optimisation, such as the sizing of inverters and climate control systems in the context of parasitic losses