The Profiling Potential of Computer Vision and the Challenge of Computational Empiricism

Computer vision and other biometrics data science applications have commenced a new project of profiling people. Rather than using 'transaction generated information', these systems measure the 'real world' and produce an assessment of the 'world state' - in this case an assessment of some individual trait. Instead of using proxies or scores to evaluate people, they increasingly deploy a logic of revealing the truth about reality and the people within it. While these profiling knowledge claims are sometimes tentative, they increasingly suggest that only through computation can these excesses of reality be captured and understood. This article explores the bases of those claims in the systems of measurement, representation, and classification deployed in computer vision. It asks if there is something new in this type of knowledge claim, sketches an account of a new form of computational empiricism being operationalised, and questions what kind of human subject is being constructed by these technological systems and practices. Finally, the article explores legal mechanisms for contesting the emergence of computational empiricism as the dominant knowledge platform for understanding the world and the people within it

The Nebraska State Capitol

A High Peak of Architectural Progress Some little while ago there appeared on this page a saying to the effect that progress is a blind succession of events fully exposed only through the agency of a capable interpreter. This issue of American Architect is proof of that contention. The Nebraska State Capitol—to which the issue is entirely devoted—is much more than an excellent example of unusual monumental design or even a symbol of democratic government. It marks an important period in the history of building progress. In many ways the architectural genius of Bertram Grosvenor Goodhue dramatized in this design a peak in the history of building accomplishment. As a break from the precedent of tradition the Nebraska State Capitol did much to advance a new and more virile architectural philosophy. From the engineering standpoint the building embodies the cumulative results of American energy, inventive skill and organizing ability; and from all combined points of view it stands as a remarkable interpretation of innumerable events that have shaped the progress of American art. industry and democratic government. For any one of these reasons American Archltect might be proud to publish the Nebraska State Capitol. In combination they make an entire issue necessary to present exclusively a most outstanding example of architectural progress. The Nebraska State Capitol — By Charles Harris Whitaker Highlights of The Capitol\u27s History — By John Edwards A Record of Successful Experiments — By Harry F. Cunningham, A.I.A Symbolism and Inscriptions — By Hartley B. Alexander, Hon. A.I.A. Color in the N ehraska StateCapitol Not in the Specifications — By Oscar H. Murray, A.I.A. An Outline of Mechanical Service Equipment — Meyer, Strong & Jones, Engineers The Story of the Capitol\u27s Construction — By Emile H. Praeger Bertram Grosvenor Goodhue • Exterior Views and Details of North Facade • Exterior Views and Details of South Facade • Plans, Elevations and Details • The Foyer • The Rotunda • The Senate Chamber • The House Chamber • Supreme Court Rooms • Memorial Hall • Governor\u27s Reception Room • Senate Lounge Cover Design by Ernest Born Acknowledgements • As It Looks to the Editors • Trends and Topics of the Times • The Readers Have a Word to Say • New Materials • Book

Broken SU(3) Symmetry in Two-Body B Decays

The decays of $B$ mesons to two-body hadronic final states are analyzed within the context of broken flavor SU(3) symmetry, extending a previous analysis involving pairs of light pseudoscalars to decays involving one or two charmed quarks in the final state. A systematic program is described for learning information {}from decay rates regarding (i) SU(3)-violating contributions, (ii) the magnitude of exchange and annihilation diagrams (effects involving the spectator quark), and (iii) strong final-state interactions. The implication of SU(3)-breaking effects for the extraction of weak phases is also examined. The present status of data on these questions is reviewed and suggestions for further experimental study are made.Comment: 38 pages, 8 figures, LaTeX file. The full postscript manuscript is available by anon ftp at ftp://lpsvsh.lps.umontreal.ca/theorie/hep-ph/SU3break.ps (a VAX so use the format theorie.hep-ph if you change by more than one directory at a time

Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction

Despite the accepted notion that granulocytes play a universally destructive role in organ and tissue grafts, it has been recently described that eosinophils can facilitate immunosuppression-mediated acceptance of murine lung allografts. The mechanism of eosinophil-mediated tolerance, or their role in regulating alloimmune responses in the absence of immunosuppression, remains unknown. Using lung transplants in a fully MHC-mismatched BALB/c (H2d) to C57BL/6 (H2b) strain combination, we demonstrate that eosinophils downregulate T cell-mediated immune responses and play a tolerogenic role even in the absence of immunosuppression. We further show that such downregulation depends on PD-L1/PD-1-mediated synapse formation between eosinophils and T cells. We also demonstrate that eosinophils suppress T lymphocyte responses through the inhibition of T cell receptor/CD3 (TCR/CD3) subunit association and signal transduction in an inducible NOS-dependent manner. Increasing local eosinophil concentration, through administration of intratracheal eotaxin and IL-5, can ameliorate alloimmune responses in the lung allograft. Thus, our data indicate that eosinophil mobilization may be utilized as a novel means of lung allograft-specific immunosuppression

Seminar on Securities Law

Materials from the UK/CLE Seminar on Securities Law held February 14-15, 1986

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD