HAGR: the Human Ageing Genomic Resources

The Human Ageing Genomic Resources (HAGR) is a collection of online resources for studying the biology of human ageing. HAGR features two main databases: GenAge and AnAge. GenAge is a curated database of genes related to human ageing. Entries were primarily selected based on genetic perturbations in animal models and human diseases as well as an extensive literature review. Each entry includes a variety of automated and manually curated information, including, where available, protein–protein interactions, the relevant literature, and a description of the gene and how it relates to human ageing. The goal of GenAge is to provide the most complete and comprehensive database of genes related to human ageing on the Internet as well as render an overview of the genetics of human ageing. AnAge is an integrative database describing the ageing process in several organisms and featuring, if available, maximum life span, taxonomy, developmental schedules and metabolic rate, making AnAge a unique resource for the comparative biology of ageing. Associated with the databases are data-mining tools and software designed to investigate the role of genes and proteins in the human ageing process as well as analyse ageing across different taxa. HAGR is freely available to the academic community at http://genomics.senescence.info

Finite Element Formalism for Micromagnetism

The aim of this work is to present the details of the finite element approach we developed for solving the Landau-Lifschitz-Gilbert equations in order to be able to treat problems involving complex geometries. There are several possibilities to solve the complex Landau-Lifschitz-Gilbert equations numerically. Our method is based on a Galerkin-type finite element approach. We start with the dynamic Landau-Lifschitz-Gilbert equations, the associated boundary condition and the constraint on the magnetization norm. We derive the weak form required by the finite element method. This weak form is afterwards integrated on the domain of calculus. We compared the results obtained with our finite element approach with the ones obtained by a finite difference method. The results being in very good agreement, we can state that our approach is well adapted for 2D micromagnetic systems.Comment: Proceedings of conference EMF200

Fast computation of magnetostatic fields by Non-uniform Fast Fourier Transforms

The bottleneck of micromagnetic simulations is the computation of the long-ranged magnetostatic fields. This can be tackled on regular N-node grids with Fast Fourier Transforms in time N logN, whereas the geometrically more versatile finite element methods (FEM) are bounded to N^4/3 in the best case. We report the implementation of a Non-uniform Fast Fourier Transform algorithm which brings a N logN convergence to FEM, with no loss of accuracy in the results

Contacting individual Fe(110) dots in a single electron-beam lithography step

We report on a new approach, entirely based on electron-beam lithography technique, to contact electrically, in a four-probe scheme, single nanostructures obtained by self-assembly. In our procedure, nanostructures of interest are localised and contacted in the same fabrication step. This technique has been developed to study the field-induced reversal of an internal component of an asymmetric Bloch domain wall observed in elongated structures such as Fe(110) dots. We have focused on the control, using an external magnetic field, of the magnetisation orientation within N\'eel caps that terminate the domain wall at both interfaces. Preliminary magneto-transport measurements are discussed demonstrating that single Fe(110) dots have been contacted.Comment: 5 page

Effect of thermal cycles on the deformation state at the crack tip of crystallizable natural rubber

International audienceThis paper deals with the effect of temperature variations on crack tip kinematicsin rubbers, especially in crystallizing rubbers. In such materials, the high deformation levelencountered at the crack tip engenders the formation of crystallites. As a consequence, thecrack tip is reinforced and resists crack growth. However, this phenomenon is signicantly affectedby variations in material temperature. This is classically observed at the macroscopicscale in terms of crack propagation rate and path. In this study, the effect of temperature isstudied at the local scale, by measuring the change in the kinematic eld at the crack tip duringthermal cycles. Results show that, in crystallizable natural rubber, the effect of temperaturedepends on the stretch ratio atained in the zone under consideration. In slightly stretchedzones, the stretch ratio increases with the increase in temperature, whereas it decreases inhighly stretched zones. This highlights the competition between the effects of the variationsin internal energy and in entropy on the thermomechanical response. Moreover, if crystallitesform in highly stretched zones, the increase in temperature leads to crystallite melting,which increases the stretch ratio. This is explained by the fact that crystallites act as llers byconcentrating the stress and therefore by increasing the apparent stiffness of the material

Head-to-head domain walls in one-dimensional nanostructures: an extended phase diagram ranging from strips to cylindrical wires

International audienceSo far magnetic domain walls in one-dimensional structures have been described theoretically only in the cases of flat strips, or cylindrical structures with a compact cross-section, either square or disk. Here we describe an extended phase diagram unifying the two pictures, extensively covering the (width,thickness) space. It is derived on the basis of symmetry and phase-transition arguments, and micromagnetic simulations. A simple classification of all domain walls in two varieties is proposed on the basis of their topology: either with a combined transverse/vortex character, or of the Bloch-point type. The exact arrangement of magnetization within each variety results mostly from the need to decrease dipolar energy, giving rise to asymmetric and curling structures. Numerical evaluators are introduced to quantify curling, and scaling laws are derived analytically for some of the iso-energy lines of the phase diagram

Average crack-front velocity during subcritical fracture propagation in a heterogeneous medium

We study the average velocity of crack fronts during stable interfacial fracture experiments in a heterogeneous quasibrittle material under constant loading rates and during long relaxation tests. The transparency of the material (polymethylmethacrylate) allows continuous tracking of the front position and relation of its evolution to the energy release rate. Despite significant velocity fluctuations at local scales, we show that a model of independent thermally activated sites successfully reproduces the large-scale behavior of the crack front for several loading conditions

Dimensionality cross-over in magnetism: from domain walls (2D) to vortices (1D)

Dimensionality cross-over is a classical topic in physics. Surprisingly it has not been searched in micromagnetism, which deals with objects such as domain walls (2D) and vortices (1D). We predict by simulation a second-order transition between these two objects, with the wall length as the Landau parameter. This was conrmed experimentally based on micron-sized ux-closure dots

Laboratory experiments on DNAPL gravity fingering in water-saturated porous media

International audienceLaboratory experiments were carried out at the Darcy scale to investigate the gravity-driven fingering phenomenon of immiscible two-phase flow of water and a dense nonaqueous-phase liquid (DNAPL) such as trichloroethylene (TCE). Rate-controlled displacement experiments were performed on a homogenous sand-filled column under various displacement conditions. Several system parameters (e.g. flow rate, flow mode (upward flow, downward flow) and mean grain-size diameter of the porous medium) were varied in the experimental programme. Optical fiber sensors were developed to quantify the spatial distribution of the advancing displacement front in a given control section of the experimental device. Following each experiment, multi-point measurements of the remaining TCE saturation were obtained by insitu soil sampling. The resulting DNAPL distribution was heterogeneous even though the medium was homogeneous sand. Higher DNAPL injection rates and lower medium permeability both reduced gravity fingering. This is because viscous forces stabilize the advancing front with pressure gradients increasing as function of the injection rate and decreasing as function of the permeability. Average residual TCE saturations obtained by mass-balance in the experiment after a complete drainage-imbibition cycle were influenced by the mean grain-size diameter of the porous medium but were not affected by the flow mode of the primary drainage process