Differences by origin in methylome suggest eco-phenotypes in the kelp Saccharina latissima

publishedVersio

Business economics in a pandemic world : how a virus changed our economic life

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Computational modeling of aging-related gene networks: a review

The aging process is a complex and multifaceted phenomenon affecting all living organisms. It involves a gradual deterioration of tissue and cellular function, leading to a higher risk of developing various age-related diseases (ARDs), including cancer, neurodegenerative, and cardiovascular diseases. The gene regulatory networks (GRNs) and their respective niches are crucial in determining the aging rate. Unveiling these GRNs holds promise for developing novel therapies and diagnostic tools to enhance healthspan and longevity. This review examines GRN modeling approaches in aging, encompassing differential equations, Boolean/fuzzy logic decision trees, Bayesian networks, mutual information, and regression clustering. These approaches provide nuanced insights into the intricate gene-protein interactions in aging, unveiling potential therapeutic targets and ARD biomarkers. Nevertheless, outstanding challenges persist, demanding more comprehensive datasets and advanced algorithms to comprehend and predict GRN behavior accurately. Despite these hurdles, identifying GRNs associated with aging bears immense potential and is poised to transform our comprehension of human health and aging. This review aspires to stimulate further research in aging, fostering the innovation of computational approaches for promoting healthspan and longevity

Intercomparison of 15 aerodynamic particle size spectrometers (APS 3321): uncertainties in particle sizing and number size distribution

Aerodynamic particle size spectrometers are a well-established method to measure number size distributions of coarse mode particles in the atmosphere. Quality assurance is essential for atmospheric observational aerosol networks to obtain comparable results with known uncertainties. In a laboratory study within the framework of ACTRIS (Aerosols, Clouds, and Trace gases Research Infrastructure Network), 15 aerodynamic particle size spectrometers (APS model 3321, TSI Inc., St. Paul, MN, USA) were compared with a focus on flow rates, particle sizing, and the unit-to-unit variability of the particle number size distribution. Flow rate deviations were relatively small (within a few percent), while the sizing accuracy was found to be within 10 % compared to polystyrene latex (PSL) reference particles. The unit-to-unit variability in terms of the particle number size distribution during this study was within 10 % to 20 % for particles in the range of 0.9 up to 3 µm, which is acceptable for atmospheric measurements. For particles smaller than that, the variability increased up to 60 %, probably caused by differences in the counting efficiencies of individual units. Number size distribution data for particles smaller than 0.9 µm in aerodynamic diameter should only be used with caution. For particles larger than 3 µm, the unit-to-unit variability increased as well. A possible reason is an insufficient sizing accuracy in combination with a steeply sloping particle number size distribution and the increasing uncertainty due to decreasing counting. Particularly this uncertainty of the particle number size distribution must be considered if higher moments of the size distribution such as the particle volume or mass are calculated, which require the conversion of the aerodynamic diameter measured to a volume equivalent diameter. In order to perform a quantitative quality assurance, a traceable reference method for the particle number concentration in the size range 0.5–3 µm is needed.JRC.H.2-Air and Climat

Depletion gilding, innovation and life-histories: The changing colours of Nahuange metalwork

The technique of depletion gilding is well evidenced in pre-Columbian Andean gold work. Artefacts from the Nahuange period in Colombia (c. AD 100-1000) were subject to metallographic, chemical and microscopic analyses to provide regional comparative data on metalworking traditions. Results suggest that depletion gilding may have been an accidental discovery and, contrary to widespread assumptions, not always a desirable feature. This research illustrates how technological innovation may not always be immediately adopted, and considers how the life-history of gold artefacts may affect their appearance and microstructure. It also offers directions for future studies of depletion gilding elsewhere

3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

International audienc