O aprendizado decorrente de uma ação de conscientização: como a atividade prática impactou alunos do curso de Medicina

INTRODUCTION: Given the dense curriculum, the insertion of the medical student in the community, right at the beginning of the course, is of great importance for their training, since it is through this insertion that the student is exposed to the problems present in the reality of the community. The subject Community Interaction proposed to the first year students to carry out an educational action about the most prevalent chronic diseases, namely Diabetes and Systemic Arterial Hypertension. Therefore, this experience report brings the observations made by the authors before, during and after the awareness action at the university campus in the year 2021, and the importance of the practical activity for the consolidation of knowledge. REPORT: The educational action took place in November 2021. The authors of this work were responsible for exposing to the community health and disease indicators related to the chronic conditions mentioned above. They decided to measure capillary blood glucose, blood pressure, calculate BMI, and distribute booklets containing general information and the reference values for the tests performed.  DISCUSSION: It is evident that extracurricular activities provide the insertion of the students in medical scenarios with participation in health care of real people as a strong component of professional learning. The student's relationship with the community prepares him to deal with the patient in a humanized way, which goes beyond pharmacological treatment. CONCLUSION: The overall result of this social action was a sum of learning that radiates to all involved: the students matured in the learning process, and the volunteers received information about their health status.INTRODUÇÃO: Diante da densa grade curricular, a inserção do aluno de Medicina na comunidade, logo no início do curso, é de suma importância para sua formação, visto que é por meio dessa inserção que o aluno é exposto às problemáticas presentes na realidade da comunidade. A disciplina de Interação Comunitária propôs aos alunos do primeiro ano que realizassem uma ação educativa acerca das doenças crônicas mais prevalentes, a saber, o Diabetes e a Hipertensão Arterial Sistêmica. Portanto, o presente relato de experiência traz as observações conferidas pelos autores antes, durante e após a realização da ação de conscientização no campus da universidade no ano de 2021, e a importância da atividade prática para a consolidação do conhecimento. RELATO: A ação educativa ocorreu em novembro de 2021. Os autores deste trabalho se responsabilizaram por expor à comunidade indicadores de saúde e doença relacionados com as condições crônicas referidas anteriormente. Optou-se, então, em aferir a glicemia capilar, a pressão arterial, a realizar o cálculo do IMC e a distribuir cartilhas contendo informações gerais e os valores de referência para os exames realizados. DISCUSSÃO: Fica evidente que as atividades extracurriculares proporcionam a inserção dos acadêmicos em cenários médicos com a participação em atenção à saúde de pessoas reais como forte componente de aprendizado profissional. A relação do aluno com a comunidade o prepara para lidar com o paciente de uma forma humanizada, que vai além do tratamento farmacológico. CONCLUSÃO: O resultado geral dessa ação social foi uma somação de aprendizado que se irradia para todos os envolvidos: os alunos amadureceram quanto ao processo de aprendizagem, e os voluntários receberam informações sobre seu estado de saúde

Divulgação científica e o projeto momento ciência

O projeto Momento Ciência tem como propósito tornar o conhecimento cientifico acessível, promovendo a divulgação científica através do contato direto de alunos de ensino médio de escolas públicas do Distrito Federal e alunos recém aprovados, calouros, nos cursos de Ciências Biológicas e de Biotecnologia na Universidade de Brasília (UnB). Esse contato com a comunidade científica ocorre por meio de visitas aos laboratórios acadêmicos do Instituto de Ciências Biológicas (IB) da Universidade de Brasília. O projeto obteve resultados positivos e esperados ao longo da sua execução

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Influence of the timing of biological treatment initiation on Juvenile Idiopathic Arthritis long-term outcomes

Abstract Background Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it is unclear what is the long-term impact on health-related outcomes of the timing of biological disease-modifying antirheumatic drug (bDMARD) initiation in JIA. Our aim was to evaluate the long-term impact of the time between JIA onset and the initiation of a bDMARD in achieving clinical remission, on physical disability and health-related quality of life (HRQoL). Methods Adult JIA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) and ever treated with bDMARD were included. Data regarding socio-demographic, JIA-related characteristics, disease activity, physical disability (HAQ-DI), HRQoL (SF-36), and treatments were collected at the last visit. Patients were divided into 3 groups (≤ 2 years, 2–5 years, or > 5 years), according to the time from disease onset to bDMARD initiation. Regression models were obtained considering remission on/off medication, HAQ-DI, SF-36, and joint surgeries as outcomes and time from disease onset to bDMARD start as an independent variable. Results Three hundred sixty-one adult JIA patients were evaluated, with a median disease duration of 20.3 years (IQR 12.1; 30.2). 40.4% had active disease, 35.1% were in remission on medication, and 24.4% were in drug-free remission; 71% reported some degree of physical disability. Starting a bDMARD > 5 years after disease onset decreased the chance of achieving remission off medication (OR 0.24; 95% CI 0.06, 0.92; p = 0.038). Patients who started a bDMARD after 5 years of disease onset had a higher HAQ and worse scores in the physical component, vitality, and social function domains of SF-36, and more joint surgeries when compared to an earlier start. Conclusion Later initiation of bDMARDs in JIA is associated with a greater physical disability, worse HRQoL, and lower chance of drug-free remission in adulthood

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six in vitro, and 76 in vivo studies. While controversial, the findings suggest that long-term use of OME (5 to 40 mg/kg) can induce genomic instability. On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction. The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices

Divulgação científica e o projeto momento ciência

O projeto Momento Ciência tem como propósito tornar o conhecimento cientifico acessível, promovendo a divulgação científica através do contato direto de alunos de ensino médio de escolas públicas do Distrito Federal e alunos recém aprovados, calouros, nos cursos de Ciências Biológicas e de Biotecnologia na Universidade de Brasília (UnB). Esse contato com a comunidade científica ocorre por meio de visitas aos laboratórios acadêmicos do Instituto de Ciências Biológicas (IB) da Universidade de Brasília. O projeto obteve resultados positivos e esperados ao longo da sua execução