Pengelolaan Pasar 66 Tagulandang Oleh Dinas Perindustrian Perdagangan Dan Tenaga Kerja Kabupaten Sitaro

Tujuan dalam penelitian ini adalah Mengetahui pengelolaan pasar 66 Tagulandang oleh Dinas Perindustrian Perdagangan dan Tenaga Kerja Kabupaten Sitaro. Kabupaten Sitaro mempunyai pasar tradisional dikenal dengan sebutan pasar 66 Tagulandang. Pasar ini merupakan sentra ekonomi bagi masyarakat Tagulandang karena sebagian dari masyarakat Tagulandang bermata pencarian sebagai pedagang. Pasar 66 Tagulandang ini menjadi tempat pertemuan antara masyarakat dari Tagulandang Utara, Tagulandang Selatan dan Tagulandang Induk. Pasar tradisional ini terletak di Kelurahan Balehumara. Sebelum diresmikannya pasar 66 Tagulandang dahulunya disebut oleh masyarakat dengan sebutan pasar Buhias. Dalam pengelolaannya masih terdapat beberapa masalah yang belum dibenahi terutama kenyamanan dalam melakukan transaksi. Penelitian ini menggunakan metode penelitian kualitatif. Hasil penelitiak disimpulkan bahwa Yang menjadi permasalahan saat ini adalah Pedagang Pasar 66 Tagulandang belum bisa menyesuaikan diri dengan kondisi yang ada. Sikap tak peduli dan tak mau tahu dengan aturan yang ada masih jelas terlihat. Juga terdapat beberapa masalah tentang penataan yang belum berjalan dengan baik.   Kata Kunci : Pengelolaan, Pasar 66, Pemerintah Daera

Chemical abundance of the LINER galaxy UGC 4805 with SDSS-IV MaNGA

Chemical abundance determinations in Low-Ionization Nuclear Line Regions (LINERs) are especially complex and uncertain because the nature of the ionizing source of this kind of object is unknown. In this work, we study the oxygen abundance in relation to the hydrogen abundance (O/H) of the gas phase of the UGC 4805 LINER nucleus. Optical spectroscopic data from the Mapping Nearby Galaxies (MaNGA) survey was employed to derive the O/H abundance of the UGC 4805 nucleus based on the extrapolation of the disk abundance gradient, on calibrations between O/H abundance and strong emission-lines for Active Galactic Nuclei (AGNs) as well as on photoionization models built with the Cloudy code, assuming gas accretion into a black hole (AGN) and post-Asymptotic Giant Branch (p-AGB) stars with different effective temperatures. We found that abundance gradient extrapolations, AGN calibrations, AGN and p-AGB photoionization models produce similar O/H values for the UGC 4805 nucleus and similar ionization parameter values. The study demonstrated that the methods used to estimate the O/H abundance using nuclear emission-line ratios produce reliable results, which are in agreement with the O/H values obtained from the independent method of galactic metallicity gradient extrapolation. Finally, the results from the WHAN diagram combined with the fact that the high excitation level of the gas has to be maintained at kpc scales, we suggest that the main ionizing source of the UGC 4805 nucleus probably has a stellar origin rather than an AGN.Fil: Krabbe, Angela. Universidade Do Vale Do Paraíba; BrasilFil: Oliveira, C. B.. Universidade Do Vale Do Paraíba; BrasilFil: Zinchenko, I. A.. Universitat Ulm. Faculty Of Natural Sciences. Institute Of Theoretical Physics; AlemaniaFil: Hernández Jiménez, J. A.. Universidad Andrés Bello; ChileFil: Dors, Oli L.. Universidade Do Vale Do Paraíba; BrasilFil: Hägele, Guillermo Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Cardaci, Monica Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Telles, N. R.. Universidade Do Vale Do Paraíba; Brasi

Gas phase metallicity determinations in nearby AGNs with SDSS-IV MaNGA: evidence of metal poor accretion

We derive the metallicity (traced by the O/H abundance) of the Narrow Line Region ( NLR) of 108 Seyfert galaxies as well as radial metallicity gradients along their galaxy disks and of these of a matched control sample of no active galaxies. In view of that, observational data from the SDSS-IV MaNGA survey and strong emission-line calibrations taken from the literature were considered. The metallicity obtained for the NLRs %each Active Galactic Nucleus (AGN) was compared to the value derived from the extrapolation of the radial oxygen abundance gradient, obtained from \ion{H}{ii} region estimates along the galaxy disk, to the central part of the host galaxies. We find that, for most of the objects ($\sim 80\,\%$), the NLR metallicity is lower than the extrapolated value, with the average difference ($$) between these estimates ranging from 0.16 to 0.30 dex. We suggest that$$ is due to the accretion of metal-poor gas to the AGN that feeds the nuclear supermassive black hole (SMBH), which is drawn from a reservoir molecular and/or neutral hydrogen around the SMBH. Additionally, we look for correlations between $D$ and the electron density ($N_{\rm e}$), [\ion{O}{iii}]$\lambda$5007 and H$\alpha$ luminosities, extinction coefficient ($A_{V})$ of the NLRs, as well as the stellar mass ($M_{*}$) of the host galaxies. Evidences of an inverse correlation between the $D$ and the parameters $N_{\rm e}$, $M_{*}$ and $A_{\rm v}$ were found

Gas-phase metallicity determinations in nearby AGNs with SDSS-IV MaNGA : evidence of metal-poor accretion

We derive the metallicity (traced by the O/H abundance) of the narrow-line region (NLR) of 108 Seyfert galaxies as well as radial metallicity gradients along their galaxy discs and of these of a matched control sample of no active galaxies. In view of that, observational data from the SDSS-IV MaNGA survey and strong emission-line calibrations taken from the literature were considered. The metallicity obtained for the NLRs was compared to the value derived from the extrapolation of the radial oxygen abundance gradient, obtained from H II region estimates along the galaxy disc, to the central part of the host galaxies. We find that, for most of the objects (∼ 80 per cent), the NLR metallicity is lower than the extrapolated value, with the average difference ( D ) between these estimates ranging from 0.16 to 0.30 dex. We suggest that D is due to the accretion of metal-poor gas to the AGN that feeds the nuclear supermassive black hole (SMBH), which is drawn from a reservoir molecular and/or neutral hydrogen around the SMBH. Additionally, we look for correlations between D and the electron density (Ne), [O III]λ5007, and H α luminosities, extinction coefficient (AV) of the NLRs, as well as the stellar mass (M∗) of the host galaxies. Evidence of an inverse correlation between the D and the parameters Ne, M∗, and Av was found

H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol.

The burden and aetiology of type 2 diabetes (T2D) and its microvascular complications may be influenced by varying behavioural and lifestyle environments as well as by genetic susceptibility. These aspects of the epidemiology of T2D have not been reliably clarified in sub-Saharan Africa (SSA), highlighting the need for context-specific epidemiological studies with the statistical resolution to inform potential preventative and therapeutic strategies. Therefore, as part of the Human Heredity and Health in Africa (H3Africa) initiative, we designed a multi-site study comprising case collections and population-based surveys at 11 sites in eight countries across SSA. The goal is to recruit up to 6000 T2D participants and 6000 control participants. We will collect questionnaire data, biophysical measurements and biological samples for chronic disease traits, risk factors and genetic data on all study participants. Through integrating epidemiological and genomic techniques, the study provides a framework for assessing the burden, spectrum and environmental and genetic risk factors for T2D and its complications across SSA. With established mechanisms for fieldwork, data and sample collection and management, data-sharing and consent for re-approaching participants, the study will be a resource for future research studies, including longitudinal studies, prospective case ascertainment of incident disease and interventional studies

RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2’-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION

Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2’O-methyltransferase (2’-OMT) through an in silico approach. Materials and Method: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol−1 with the SARS-CoV-2 2’-OMT was used as a standard. Compounds were screened for bioavailability through the SWISSADME web server using their molecular descriptors. Screenings for pharmacokinetic properties and bioactivity were performed with PKCSM and Molinspiration web servers respectively. The PLIP and Fpocket webservers were used for the binding site analyses. The Galaxy webserver was used for simulating the time-resolved motions of the apo and holo forms of the target while the MDWeb web server was used for the analyses of the trajectory data. Results: The Root-Mean-Square-Deviation (RMSD) induced by Rhamnetin is 1.656A0 as compared to Dolutegravir (1.579A0). The average B-factor induced by Rhamnetin is 113.75 while for Dolutegravir is 78.87; the Root-Mean-Square-Fluctuation (RMSF) for Rhamnetin is 0.75 and for Dolutegravir is 0.67. Also at the active site, Rhamnetin also has a binding affinity score of -9.5 kcal mol−1 and forms 7 hydrogen bonds as compared to Dolutegravir which has -8.5 kcal mol−1 and forms 4 hydrogen bonds respectively. Conclusion: Rhamnetin showed better inhibitory activity at the target’s active site than Dolutegravir

The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and healthcare providers

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Research questions were elicited and then prioritised in successive surveys. A workshop agreed the final top 10. Online methods avoided cross infection and widened participation. The elicitation survey had 482 respondents (1080 questions) and prioritisation survey 677 respondents. Participants were drawn equally from the patient and clinical communities globally. We have achieved a consensus on 10 research priorities which will be attractive to funders

ADC Nonlinearity Correction for the Majorana Demonstrator

Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment's high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay Q value

Chemical abundance of the LINER galaxy UGC 4805 with SDSS-IV MaNGA

Chemical abundance determinations in Low-Ionization Nuclear Line Regions (LINERs) are especially complex and uncertain because the nature of the ionizing source of this kind of object is unknown. In this work, we study the oxygen abundance in relation to the hydrogen abundance (O/H) of the gas phase of the UGC 4805 LINER nucleus. Optical spectroscopic data from the Mapping Nearby Galaxies (MaNGA) survey was employed to derive the O/H abundance of the UGC 4805 nucleus based on the extrapolation of the disk abundance gradient, on calibrations between O/H abundance and strong emission-lines for Active Galactic Nuclei (AGNs) as well as on photoionization models built with the Cloudy code, assuming gas accretion into a black hole (AGN) and post-Asymptotic Giant Branch (p-AGB) stars with different effective temperatures. We found that abundance gradient extrapolations, AGN calibrations, AGN and p-AGB photoionization models produce similar O/H values for the UGC 4805 nucleus and similar ionization parameter values. The study demonstrated that the methods used to estimate the O/H abundance using nuclear emission-line ratios produce reliable results, which are in agreement with the O/H values obtained from the independent method of galactic metallicity gradient extrapolation. Finally, the results from the WHAN diagram combined with the fact that the high excitation level of the gas has to be maintained at kpc scales, we suggest that the main ionizing source of the UGC 4805 nucleus probably has a stellar origin rather than an AGN.Instituto de Astrofísica de La Plat