Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis : effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Background: Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between the central nervous system, peripheral tissues, and gut microbiota, and is affected by genetics. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS) aims to gain new systems-level understanding of the central metabolism in human body, and how exercise training affects this cross-talk. Methods: CROSSYS is an exercise training intervention, in which participants are monozygotic twins from pairs discordant for body mass index (BMI) and within a pair at least the other is overweight. Twins are recruited from three population-based longitudinal Finnish twin studies, including twins born in 1983-1987, 1975-1979, and 1945-1958. The participants undergo 6-month-long exercise intervention period, exercising four times a week (including endurance, strength, and high-intensity training). Before and after the exercise intervention, comprehensive measurements are performed in Turku PET Centre, Turku, Finland. The measurements include: two positron emission tomography studies (insulin-stimulated whole-body and tissue-specific glucose uptake and neuroinflammation), magnetic resonance imaging (brain morphology and function, quantification of body fat masses and organ volumes), magnetic resonance spectroscopy (quantification of fat within heart, pancreas, liver and tibialis anterior muscle), echocardiography, skeletal muscle and adipose tissue biopsies, a neuropsychological test battery as well as biosamples from blood, urine and stool. The participants also perform a maximal exercise capacity test and tests of muscular strength. Discussion: This study addresses the major public health problems related to modern lifestyle, obesity, and physical inactivity. An eminent strength of this project is the possibility to study monozygotic twin pairs that share the genome at the sequence level but are discordant for BMI that is a risk factor for metabolic impairments such as insulin resistance. Thus, this exercise training intervention elucidates the effects of obesity on metabolism and whether regular exercise training is able to reverse obesity-related impairments in metabolism in the absence of the confounding effects of genetic factors.Peer reviewe

Gender and gaze gesture recognition for human-computer interaction

© 2016 Elsevier Inc. The identification of visual cues in facial images has been widely explored in the broad area of computer vision. However theoretical analyses are often not transformed into widespread assistive Human-Computer Interaction (HCI) systems, due to factors such as inconsistent robustness, low efficiency, large computational expense or strong dependence on complex hardware. We present a novel gender recognition algorithm, a modular eye centre localisation approach and a gaze gesture recognition method, aiming to escalate the intelligence, adaptability and interactivity of HCI systems by combining demographic data (gender) and behavioural data (gaze) to enable development of a range of real-world assistive-technology applications. The gender recognition algorithm utilises Fisher Vectors as facial features which are encoded from low-level local features in facial images. We experimented with four types of low-level features: greyscale values, Local Binary Patterns (LBP), LBP histograms and Scale Invariant Feature Transform (SIFT). The corresponding Fisher Vectors were classified using a linear Support Vector Machine. The algorithm has been tested on the FERET database, the LFW database and the FRGCv2 database, yielding 97.7%, 92.5% and 96.7% accuracy respectively. The eye centre localisation algorithm has a modular approach, following a coarse-to-fine, global-to-regional scheme and utilising isophote and gradient features. A Selective Oriented Gradient filter has been specifically designed to detect and remove strong gradients from eyebrows, eye corners and self-shadows (which sabotage most eye centre localisation methods). The trajectories of the eye centres are then defined as gaze gestures for active HCI. The eye centre localisation algorithm has been compared with 10 other state-of-the-art algorithms with similar functionality and has outperformed them in terms of accuracy while maintaining excellent real-time performance. The above methods have been employed for development of a data recovery system that can be employed for implementation of advanced assistive technology tools. The high accuracy, reliability and real-time performance achieved for attention monitoring, gaze gesture control and recovery of demographic data, can enable the advanced human-robot interaction that is needed for developing systems that can provide assistance with everyday actions, thereby improving the quality of life for the elderly and/or disabled

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Background: Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between the central nervous system, peripheral tissues, and gut microbiota, and is affected by genetics. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS) aims to gain new systems-level understanding of the central metabolism in human body, and how exercise training affects this cross-talk.Methods: CROSSYS is an exercise training intervention, in which participants are monozygotic twins from pairs discordant for body mass index (BMI) and within a pair at least the other is overweight. Twins are recruited from three population-based longitudinal Finnish twin studies, including twins born in 1983-1987, 1975-1979, and 1945-1958. The participants undergo 6-month-long exercise intervention period, exercising four times a week (including endurance, strength, and high-intensity training). Before and after the exercise intervention, comprehensive measurements are performed in Turku PET Centre, Turku, Finland. The measurements include: two positron emission tomography studies (insulin-stimulated whole-body and tissue-specific glucose uptake and neuroinflammation), magnetic resonance imaging (brain morphology and function, quantification of body fat masses and organ volumes), magnetic resonance spectroscopy (quantification of fat within heart, pancreas, liver and tibialis anterior muscle), echocardiography, skeletal muscle and adipose tissue biopsies, a neuropsychological test battery as well as biosamples from blood, urine and stool. The participants also perform a maximal exercise capacity test and tests of muscular strength.Discussion: This study addresses the major public health problems related to modern lifestyle, obesity, and physical inactivity. An eminent strength of this project is the possibility to study monozygotic twin pairs that share the genome at the sequence level but are discordant for BMI that is a risk factor for metabolic impairments such as insulin resistance. Thus, this exercise training intervention elucidates the effects of obesity on metabolism and whether regular exercise training is able to reverse obesity-related impairments in metabolism in the absence of the confounding effects of genetic factors

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Performance Analysis of a Traffic Control System Using Stochastic Petri Nets

: This paper discusses the modelling and performance analysis of signalized trac control systems using the Deterministic and Stochastic Petri Net (DSPN) formalism. We develop a formal DSPN model for a group of interconnected signalized trac intersections and present performance indices obtained from simulation runs of example systems. Keywords: performance analysis, trac control, Stochastic Petri Nets Printing: Picaset Oy 1999 Helsinki University of Technology Phone: 09 +3589 4511 Department of Computer Science and Engineering Digital Systems Laboratory Telex: 125 161 htkk P.O.Box 1100 Telefax: +3589451 3369 FIN02015 HUT, FINLAND E-mail: [email protected]. This talk was given at the Fourteenth UK Computer and Telecommunications Performance Engineering Workshop (UK PEW 1998), July 910, 1998, Edinburgh. 1 6 - ? - - ? 6 6 ? Figure 1: A simple road junction. 1 Introduction Trac control is an important topic that has great impact on t..