One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening

Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large-scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequential drug combinations in clinical applications and academic investigations. Here, a miniaturized platform for high-throughput combinatorial drug screening that is "pipetting-free" and scalable for the screening of sequential drug combinations is presented. The platform uses parallel and bottom-up formation of a heterogeneous drug-releasing hydrogel microarray by self-assembly of drug-laden hydrogel microparticles. This approach eliminates the need for liquid handling systems and time-consuming operation in high-throughput large-scale screening. In addition, the serial replacement of the drug-releasing microarray-on-a-chip facilitates different drug exchange in each and every microwell in a simple and highly parallel manner, supporting scalable implementation of multistep combinatorial screening. The proposed strategy can be applied to various forms of combinatorial drug screening with limited amounts of samples and resources, which will broaden the use of the large-scale screening for precision medicine

The Student Movement Volume 108 Issue 1: \u2723 and me: Welcome to the AU Family!

HUMANS Babbling at the Crayon Box, Anneliese Tessalee Dorm Sweet Dorm, Savannah Tyler Surviving Freshman Year 101, Colin Cha ARTS & ENTERTAINMENT AU\u27s Reception of Barbie , Amelia Stefanescu Hey, How Was Your Summer? , Nailea Soto Sewing as an Art Form: My Experience as a First-Time Formal Dressmaker, Daena Holbrook Shadow & Bone: Reentering the Grishaverse, Madison Vath NEWS Another Generation, Another Convocation, Melissa Moore Canada\u27s Fiery Struggle: The Ongoing Battle Against Wildfires, Brendan Oh Labor Day, the Writers\u27 Strikes, and Fairness, Nathaniel Miller IDEAS Antibiotic Resistance, Sumin Lee Chapel Credits: Fair or Unfair?, Corinna Bevier From Flowers to Fires: Does Climate Change Rhetoric Need to Change?, Bella Hamann Suicide Prevention Month and the Power of Support, Reagan Westerman PULSE All That and Then Summer, Lexie Dunham Food Near AU, Alyssa Caruthers Mirror, Mirror on the Wall, is There a Fairest of Them All?, Anna Rybachek Social Media Fasts, Rodney Bell II LAST WORD You Are a God Who Sees Me, Chris Ngugihttps://digitalcommons.andrews.edu/sm-108/1000/thumbnail.jp

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Epidemiological and Genome-Wide Association Study of Gastritis or Gastric Ulcer in Korean Populations

Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the high risk factors of gastritis in each gender in the Korean population by focusing on sex. We performed an analysis of 120 clinical characteristics and genome-wide association studies (GWAS) using 349,184 single-nucleotide polymorphisms from the results of Anseong and Ansan cohort study in the Korea Association Resource (KARE) project. As the result, we could not prove a strong relation with these factors and gastritis or gastric ulcer in the GWAS. However, we confirmed several already-known risk factors and also found some differences of clinical characteristics in each gender using logistic regression. As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males

Eurhadina Haupt 1929

Genus Eurhadina Haupt, 1929 Eurhadina Haupt, 1929: 1075 (Type species: Cicada pulchella Fallén, 1806) Diagnosis. Face anterior part swollen in lateral view. Body depressed and robust. Forewing narrow and usually with one dark brown spot on M 1 + 2 vein. Hind wing submarginal vein absent at apex and with vannal vein. Subgenital plate nearly straight and slightly curved, with one macroseta near basal margin and several microsetae at apex. Apex of style simply pointed and bent, without tooth on inner side. Aedeagus strongly recurved in lateral view, with two pairs of branches at apex.Published as part of Oh, Sumin, Lim, Jongok & Jung, Sunghoon, 2016, A new species of the genus Eurhadina Haupt (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea, with a key to Korean species in Zootaxa 4103 (1), DOI: 10.11646/zootaxa.4103.1.7, http://zenodo.org/record/26250

Eurhadina

Key to the Eurhadina species of the Korean Peninsula 1. Aedeagus with apical processes branched......................................................................................................................................... 2 Aedeagus with apical processes unbranched..................................................................................................................................... 4 2. Aedeagus with preapical process branched....................................................................................................................................... 3 Aedeagus with preapical process unbranched................................................................................ E. (E.) betularia Anufriev, 1969 3. Aedeagus with branch of preapical process originating at same point as branch of inner process..................................................... .................................................................................................................................................. E. (E.) wagneri Dworakowska, 1969 Aedeagus with branch of preapical process originating at ending point of apical process.............. E. (E.) pulchella (Fallen, 1806) 4. Aedeagus preapical process with 2 branches........................................................................... E. (E.) koreana Dworakowska, 1971 Aedeagus preapical process with 3 branches (Fig. 5) .......................................................................... E. (E.) dongwolensis sp. nov.Published as part of Oh, Sumin, Lim, Jongok & Jung, Sunghoon, 2016, A new species of the genus Eurhadina Haupt (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea, with a key to Korean species in Zootaxa 4103 (1), DOI: 10.11646/zootaxa.4103.1.7, http://zenodo.org/record/26250

A new species of the genus Eurhadina Haupt (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea, with a key to Korean species

Oh, Sumin, Lim, Jongok, Jung, Sunghoon (2016): A new species of the genus Eurhadina Haupt (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea, with a key to Korean species. Zootaxa 4103 (1), DOI: 10.11646/zootaxa.4103.1.

FIGURES 8–14 in A new species and two new records of the leafhopper genus Iassus Fabricius (Hemiptera: Auchenorrhyncha: Cicadellidae) from Korea, with a key to the Korean Iassus species

FIGURES 8–14. Iassus iziaslavi (Anufriev, 1977): 8. Male's habitus. 9. Pygofer lobe, processes and pygofer appendage. 10. Subgenitalplate. 11. Aedeagus in lateral view. 12. Aedeagus in ventral view. 13. Style. 14. Connective. Scales: (8) 1mm; (9–14) 0.1mm

Two new species of the genus Arboridia Zachvatkin (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea

Oh, Sumin, Choe, Kwang-Ryul, Jung, Sunghoon (2015): Two new species of the genus Arboridia Zachvatkin (Hemiptera: Auchenorrhyncha: Cicadellidae: Typhlocybinae) from Korea. Zootaxa 3918 (3): 446-450, DOI: http://dx.doi.org/10.11646/zootaxa.3918.3.