‘There is no choice apart from antibiotics…’: qualitative analysis of views on urinary infections in pregnancy and antimicrobial resistance

Background: Antimicrobial resistance (AMR) is a health risk as it can lead to life-threatening infections. There has been a rise in resistant urinary tract infections (UTIs) which is the most common infection in pregnancy. This can be challenging in pregnancy due to the additional need to safeguard foetal development. The study's aim was to explore views about AMR in women who experienced UTIs in pregnancy. Design: Fifteen semi-structured interviews were conducted in the UK and analysed using thematic analysis. Results: Results highlighted two themes: conceptualization of AMR and pregnancy as a deviation from the norm, with an overarching theme of ‘self-efficacy’. Results show that participants were concerned about AMR but uncertain about the effect on society compared to individual's taking antibiotics and about completing antibiotic courses. Participants reported an unsparing use of antibiotics was justified in pregnancy, and behaviours like drinking adequate water were ineffective at preventing UTIs. In summary, women had low self-efficacy regards tackling AMR and managing their health. Conclusion: Misconceptions about how AMR affects society vs the individual translated into viewing it as a future problem to be tackled by the health-care sector. Consequently, AMR requires reconceptualization as a current problem requiring collective action. This research also indicates women endorse a biomedical model of UTIs in pregnancy which attributes resolving illness to interventions such as medicines, implying an automatic reliance on antibiotics. Subsequently, there is a need for self-efficacy by focusing on a behavioural model which emphasizes behaviours for infection prevention, thus reducing the need for antibiotics

Spectrophotometric analysis of ternary uranyl systems to replace tri-N-butyl phosphate (TBP) in used fuel reprocessing

In this report, the interaction of monoamide/diamide and monoamide/diglycolamide mixtures with UO2+2 are investigated in pH = 1 methanolic nitric acid media. These monoamides include N,N-dimethylacetamide (DMAA), N,N-diethylacetamide (DEAA), N,N-dibutylacetamide (DBAA) and N,N-dibutylbutanamide (DBBA). N,N,N′N′-tetraethylmalonamide (TEMA) and N,N,N′,N′-tetraethyldiglycolamide (TEDGA), which were chosen as model diamides and diglycolamides, respectively. Complex stability constants for each ligand were modelled using the Stability Quotients Using Absorbance Data program using UV–visible data. Complex stoichiometry of ligand mixtures was determined using Job plots and UV–Vis spectrometry. Monoamides were confirmed to produce only disolvate complexes with UO2+2 in solution. The log10(K) values for monoamides were found to be independent of amine-side chain length, but were slightly dependent on the carbonyl-side chain length. TEDGA was found to produce multiple uranyl complexes in solution. Job plot data indicated that the uranyl cation strongly prefers to bond either only with the monoamide or diamide in ternary monoamide–diamide–UO2 systems. Monoamide–diglycolamide–UO2 systems were more complicated, with Job plot data indicating the potential for multiple ternary species being present is dependent on the monoamide structure

Azimuthal shear of a transversely isotropic elastic solid

In this paper we study the problem of (plane strain) azimuthal shear of a circular cylindrical tube of incompressible transversely isotropic elastic material subject to finite deformation. The preferred direction associated with the transverse isotropy lies in the planes normal to the tube axis and is at an angle with the radial direction that depends only on the radius. For a general form of strain-energy function the considered deformation yields simple expressions for the azimuthal shear stress and the associated strong ellipticity condition in terms of the azimuthal shear strain. These apply for a sense of shear that is either “with” or “against” the preferred direction (anticlockwise and clockwise, respectively), so that material line elements locally in the preferred direction either extend or (at least initially) contract, respectively. For some specific strain-energy functions we then examine local loss of uniqueness of the shear stress–strain relationship and failure of ellipticity for the case of contraction and the dependence on the geometry of the preferred direction. In particular, for a reinforced neo-Hookean material, we obtain closed-form solutions that determine the domain of strong ellipticity in terms of the relationship between the shear strain and the angle (in general, a function of the radius) between the tangent to the preferred direction and the undeformed radial direction. It is shown, in particular, that as the magnitude of the applied shear stress increases then, after loss of ellipticity, there are two admissible values for the shear strain at certain radial locations. Absolutely stable deformations involve the lower magnitude value outside a certain radius and the higher magnitude value within this radius. The radius that separates the two values increases with increasing magnitude of the shear stress. The results are illustrated graphically for two specific forms of energy function

Elastic cavitation, tube hollowing, and differential growth in plants and biological tissues

Elastic cavitation is a well-known physical process by which elastic materials under stress can open cavities. Usually, cavitation is induced by applied loads on the elastic body. However, growing materials may generate stresses in the absence of applied loads and could induce cavity opening. Here, we demonstrate the possibility of spontaneous growth-induced cavitation in elastic materials and consider the implications of this phenomenon to biological tissues and in particular to the problem of schizogenous aerenchyma formation

The differential recruitment of executive functions during time, number and length perception: An individual differences approach.

Developmental, behavioural and neurological similarities in the processing of different magnitudes (time, number, space) support the existence of a common magnitude processing system (e.g. ATOM; Bueti & Walsh, 2009; Walsh, 2003). It is however unclear whether the recruitment of wider cognitive resources (STM and executive function) during magnitude processing is similar across magnitude domains or domain specific. The current study used an individual differences approach to examine the relationship between STM, executive function and magnitude processing. In two experiments, participants completed number, length and duration bisection tasks to assess magnitude processing and tasks which have been shown to assess STM span and the four key executive component processes identified by Miyake et al. (2000) and Fisk and Sharp (2004) (shifting, inhibition, updating and access). The results suggest that the recruitment of STM and executive resources differed for the different magnitude domains. Duration perception was associated with access, inhibition and STM span. Length processing was associated with updating and number processing was associated with access to semantic memory. For duration and length, greater difficulty in the magnitude judgement task resulted in more relationships to STM and executive function. It is suggested that duration perception may be more demanding of STM and executive resources because it is represented sequentially, unlike length and number which can be represented non-sequentially

Improving cost-efficiency of faecal genotyping:new tools for elephant species

Despite the critical need for non-invasive tools to improve monitoring of wildlife populations, especially for endangered and elusive species, faecal genetic sampling has not been adopted as regular practice, largely because of the associated technical challenges and cost. Substantial work needs to be undertaken to refine sample collection and preparation methods in order to improve sample set quality and provide cost-efficient tools that can effectively support wildlife management. In this study, we collected an extensive set of forest elephant (Loxodonta cyclotis) faecal samples throughout Gabon, Central Africa, and prepared them for genotyping using 107 single-nucleotide polymorphism assays. We developed a new quantitative polymerase chain reaction (PCR) assay targeting a 130-bp nuclear DNA fragment and demonstrated its suitability for degraded samples in all three elephant species. Using this assay to compare the efficacy of two sampling methods for faecal DNA recovery, we found that sampling the whole surface of a dung pile with a swab stored in a small tube of lysis buffer was a convenient method producing high extraction success and DNA yield. We modelled the influence of faecal quality and storage time on DNA concentration in order to provide recommendations for optimized collection and storage. The maximum storage time to ensure 75% success was two months for samples collected within 24 hours after defecation and extended to four months for samples collected within one hour. Lastly, the real-time quantitative PCR assay allowed us to predict genotyping success and pre-screen DNA samples, thus further increasing the cost-efficiency of our approach. We recommend combining the validation of an efficient sampling method, the build of in-country DNA extraction capacity for reduced storage time and the development of species-specific quantitative PCR assays in order to increase the cost-efficiency of routine non-invasive DNA analyses and expand the use of next-generation markers to non-invasive samples

First Results from the CHARA Array. II. A Description of the Instrument

The CHARA Array is a six 1-m telescope optical/IR interferometric array located on Mount Wilson California, designed and built by the Center for High Angular Resolution Astronomy of Georgia State University. In this paper we describe the main elements of the Array hardware and software control systems as well as the data reduction methods currently being used. Our plans for upgrades in the near future are also described

Energy Spectrum Evolution of a Diffuse Field in Elastic Body Caused by Weak Nonlinearity

We study the evolution of diffuse elastodynamic spectral energy density under the influence of weak nonlinearity. It is shown that the rate of change of this quantity is given by a convolution of the linear energy at two frequencies. Quantitative estimates are given for sample aluminum and fused silica blocks of experimental interest.Comment: 9 pages, 3 figures; revised for better presentatio