1,054 research outputs found
Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts
p38 MAP kinase is known to be activated by cellular stress finally leading to cell cycle arrest or apoptosis. Furthermore, a tumour suppressor role of p38 MAPK has been proposed. In contrast, a requirement of p38 for proliferation has also been described. To clarify this paradox, we investigated stress- and mitogen-induced p38 signalling in the same cell type using fibroblasts. We demonstrate that - in the same cell line - p38 is activated by mitogens or cellular stress, but p38-dependent signalling is different. Exposure to cellular stress, such as anisomycin, leads to a strong and persistent p38 activation independent of GTPases. As a result, MK2 and downstream the transcription factor CREB are phosphorylated. In contrast, mitogenic stimulation results in a weaker and transient p38 activation, which upstream involves small GTPases and is required for cyclin D1 induction. Consequently, the retinoblastoma protein is phosphorylated and allows G1/S transition. Our data suggest a dual role of p38 and indicate that the level and/or duration of p38 activation determines the cellular response, i.e either proliferation or cell cycle arrest
Expanded Search for z~10 Galaxies from HUDF09, ERS, and CANDELS Data: Evidence for Accelerated Evolution at z>8?
We search for z~10 galaxies over ~160 arcmin^2 of WFC3/IR data in the Chandra
Deep Field South, using the public HUDF09, ERS, and CANDELS surveys, that reach
to 5sigma depths ranging from 26.9 to 29.4 in H_160 AB mag. z>~9.5 galaxy
candidates are identified via J_125-H_160>1.2 colors and non-detections in any
band blueward of J_125. Spitzer IRAC photometry is key for separating the
genuine high-z candidates from intermediate redshift (z~2-4) galaxies with
evolved or heavily dust obscured stellar populations. After removing 16 sources
of intermediate brightness (H_160~24-26 mag) with strong IRAC detections, we
only find one plausible z~10 galaxy candidate in the whole data set, previously
reported in Bouwens et al. (2011). The newer data cover a 3x larger area and
provide much stronger constraints on the evolution of the UV luminosity
function (LF). If the evolution of the z~4-8 LFs is extrapolated to z~10, six
z~10 galaxies are expected in our data. The detection of only one source
suggests that the UV LF evolves at an accelerated rate before z~8. The
luminosity density is found to increase by more than an order of magnitude in
only 170 Myr from z~10 to z~8. This increase is >=4x larger than expected from
the lower redshift extrapolation of the UV LF. We are thus likely witnessing
the first rapid build-up of galaxies in the heart of cosmic reionization.
Future deep HST WFC3/IR data, reaching to well beyond 29 mag, can enable a more
robust quantification of the accelerated evolution around z~10.Comment: 13 pages, 11 figures, ApJ resubmitted after referee repor
Very blue UV-continuum slopes of low luminosity z~7 galaxies from WFC3/IR: Evidence for extremely low metallicities?
We use the ultra-deep WFC3/IR data over the HUDF and the Early Release
Science WFC3/IR data over the CDF-South GOODS field to quantify the broadband
spectral properties of candidate star-forming galaxies at z~7. We determine the
UV-continuum slope beta in these galaxies, and compare the slopes with galaxies
at later times to measure the evolution in beta. For luminous L*(z=3) galaxies,
we measure a mean UV-continuum slope beta of -2.0+/-0.2, which is comparable to
the beta~-2 derived at similar luminosities at z~5-6. However, for the lower
luminosity 0.1L*(z=3) galaxies, we measure a mean beta of -3.0+/-0.2. This is
substantially bluer than is found for similar luminosity galaxies at z~4, just
800 Myr later, and even at z~5-6. In principle, the observed beta of -3.0 can
be matched by a very young, dust-free stellar population, but when nebular
emission is included the expected beta becomes >~-2.7. To produce these very
blue beta's (i.e., beta~-3), extremely low metallicities and mechanisms to
reduce the red nebular emission are likely required. For example, a large
escape fraction (i.e., f_{esc}>~0.3) could minimize the contribution from this
red nebular emission. If this is correct and the escape fraction in faint z~7
galaxies is >~0.3, it may help to explain how galaxies reionize the universe.Comment: 5 pages, 5 figures, accepted for publication in Astrophysical Journal
Letter
UV Luminosity Functions from 132 z~7 and z~8 Lyman-Break Galaxies in the ultra-deep HUDF09 and wide-area ERS WFC3/IR Observations
We identify 73 z~7 and 59 z~8 candidate galaxies in the reionization epoch,
and use this large 26-29.4 AB mag sample of galaxies to derive very deep
luminosity functions to <-18 AB mag and the star formation rate density at z~7
and z~8. The galaxy sample is derived using a sophisticated Lyman-Break
technique on the full two-year WFC3/IR and ACS data available over the HUDF09
(~29.4 AB mag, 5 sigma), two nearby HUDF09 fields (~29 AB mag, 14 arcmin) and
the wider area ERS (~27.5 AB mag) ~40 arcmin**2). The application of strict
optical non-detection criteria ensures the contamination fraction is kept low
(just ~7% in the HUDF). This very low value includes a full assessment of the
contamination from lower redshift sources, photometric scatter, AGN, spurious
sources, low mass stars, and transients (e.g., SNe). From careful modelling of
the selection volumes for each of our search fields we derive luminosity
functions for galaxies at z~7 and z~8 to <-18 AB mag. The faint-end slopes
alpha at z~7 and z~8 are uncertain but very steep at alpha = -2.01+/-0.21 and
alpha=-1.91+/-0.32, respectively. Such steep slopes contrast to the local
alpha<~-1.4 and may even be steeper than that at z~4 where alpha=-1.73+/-0.05.
With such steep slopes (alpha<~-1.7) lower luminosity galaxies dominate the
galaxy luminosity density during the epoch of reionization. The star formation
rate densities derived from these new z~7 and z~8 luminosity functions are
consistent with the trends found at later times (lower redshifts). We find
reasonable consistency, with the SFR densities implied from reported stellar
mass densities, being only ~40% higher at z<7. This suggests that (1) the
stellar mass densities inferred from the Spitzer IRAC photometry are reasonably
accurate and (2) that the IMF at very high redshift may not be very different
from that at later times.Comment: 38 pages, 21 figures, 20 tables, ApJ, accepted for publicatio
Overdensities of Y-dropout Galaxies from the Brightest-of-Reionizing Galaxies Survey: A Candidate Protocluster at Redshift z~8
Theoretical and numerical modeling of dark-matter halo assembly predicts that
the most luminous galaxies at high redshift are surrounded by overdensities of
fainter companions. We test this prediction with HST observations acquired by
our Brightest of Reionizing Galaxies (BoRG) survey, which identified four very
bright z~8 candidates as Y-dropout sources in four of the 23 non-contiguous
WFC3 fields observed. We extend here the search for Y-dropouts to fainter
luminosities (M_* galaxies with M_AB\sim-20), with detections at >5sigma
confidence (compared to >8sigma confidence adopted earlier) identifying 17 new
candidates. We demonstrate that there is a correlation between number counts of
faint and bright Y-dropouts at >99.84% confidence. Field BoRG58, which contains
the best bright z\sim8 candidate (M_AB=-21.3), has the most significant
overdensity of faint Y-dropouts. Four new sources are located within 70arcsec
(corresponding to 3.1 comoving Mpc at z=8) from the previously known brighter
z\sim8 candidate. The overdensity of Y-dropouts in this field has a physical
origin to high confidence (p>99.975%), independent of completeness and
contamination rate of the Y-dropout selection. We modeled the overdensity by
means of cosmological simulations and estimate that the principal dark matter
halo has mass M_h\sim(4-7)x10^11Msun (\sim5sigma density peak) and is
surrounded by several M_h\sim10^11Msun halos which could host the fainter
dropouts. In this scenario, we predict that all halos will eventually merge
into a M_h>2x10^14Msun galaxy cluster by z=0. Follow-up observations with
ground and space based telescopes are required to secure the z\sim8 nature of
the overdensity, discover new members, and measure their precise redshift.Comment: Minor revision: ApJ accepted [17 pages (emulateapj style), 7 figures,
2 tables
Ultradeep Infrared Array Camera Observations of sub-L* z~7 and z~8 Galaxies in the Hubble Ultra Deep Field: the Contribution of Low-Luminosity Galaxies to the Stellar Mass Density and Reionization
We study the Spitzer Infrared Array Camera (IRAC) mid-infrared (rest-frame
optical) fluxes of 14 newly WFC3/IR-detected z=7 z_{850}-dropout galaxies and 5
z=8 Y_{105}-dropout galaxies. The WFC3/IR depth and spatial resolution allow
accurate removal of contaminating foreground light, enabling reliable flux
measurements at 3.6 micron and 4.5 micron. None of the galaxies are detected to
[3.6]=26.9 (AB, 2 sigma), but a stacking analysis reveals a robust detection
for the z_{850}-dropouts and an upper limit for the Y_{105}-dropouts. We
construct average broadband SEDs using the stacked ACS, WFC3, and IRAC fluxes
and fit stellar population synthesis models to derive mean redshifts, stellar
masses, and ages. For the z_{850}-dropouts, we find z=6.9^{+0.1}_{-0.1},
(U-V)_{rest}=0.4, reddening A_V=0, stellar mass M*=1.2^{+0.3}_{-0.6} x 10^9
M_sun (Salpeter IMF). The best-fit ages ~300Myr, M/L_V=0.2, and
SSFR=1.7Gyr^{-1} are similar to values reported for luminous z=7 galaxies,
indicating the galaxies are smaller but not younger. The sub-L* galaxies
observed here contribute significantly to the stellar mass density and under
favorable conditions may have provided enough photons for sustained
reionization at 7<z<11. In contrast, the z=8.3^{+0.1}_{-0.2} Y_{105}-dropouts
have stellar masses that are uncertain by 1.5 dex due to the near-complete
reliance on far-UV data. Adopting the 2 sigma upper limit on the M/L(z=8), the
stellar mass density to M_{UV,AB} < -18 declines from
rho*(z=7)=3.7^{+1.0}_{-1.8} x 10^6 M_sun Mpc^{-3} to rho*(z=8) < 8 x 10^5 M_sun
Mpc^{-3}, following (1+z)^{-6} over 3<z<8. Lower masses at z=8 would signify
more dramatic evolution, which can be established with deeper IRAC
observations, long before the arrival of the James Webb Space Telescope.Comment: 6 pages, 3 figures, 2 tables, emulateapj, accepted for publication in
ApJ
The Luminosity Function at z~8 from 97 Y-band dropouts: Inferences About Reionization
[Abbreviated] We present the largest search to date for Lyman break
galaxies (LBGs) based on 350 arcmin of HST observations in the V-, Y-, J-
and H-bands from the Brightest of Reionizing Galaxies (BoRG) survey. The BoRG
dataset includes 50 arcmin of new data and deeper observations of two
previous BoRG pointings, from which we present 9 new LBG candidates,
bringing the total number of BoRG LBGs to 38 with (AB system). We introduce a new Bayesian formalism for
estimating the galaxy luminosity function (LF), which does not require binning
(and thus smearing) of the data and includes a likelihood based on the formally
correct binomial distribution as opposed to the often used approximate Poisson
distribution. We demonstrate the utility of the new method on a sample of
LBGs that combines the bright BoRG galaxies with the fainter sources published
in Bouwens et al. (2012) from the HUDF and ERS programs. We show that the
LF is well described by a Schechter function with a characteristic
magnitude , a faint-end slope of , and a number density of . Integrated down to this
LF yields a luminosity density, . Our LF analysis
is consistent with previously published determinations within 1. We
discuss the implication of our study for the physics of reionization. By
assuming theoretically motivated priors on the clumping factor and the photon
escape fraction we show that the UV LF from galaxy samples down to
can ionize only 10-50% of the neutral hydrogen at . Full reionization
would require extending the LF down to .Comment: Accepted for publication in ApJ, 22 pages, 15 figure
The bright-end galaxy candidates at z ~ 9 from 79 independent HST fields
We present a full data analysis of the pure-parallel Hubble Space Telescope
(HST) imaging observations in the Brightest of Reionizing Galaxies Survey
(BoRG[z9]) in Cycle 22. The medium-deep exposures with five HST/WFC3IR+UVIS
filter bands from 79 independent sightlines (~370 arcmin^2) provide the least
biased determination of number density for z>9 bright galaxies against cosmic
variance. After a strict two-step selection for candidate galaxies, including
dropout color and photometric redshift analyses, and revision of previous BoRG
candidates, we identify one source at z~10 and two sources at z~9. The z~10
candidate shows evidence of line-of-sight lens magnification (mu~1.5), yet it
appears surprisingly luminous (MUV ~ -22.6\pm0.3 mag), making it one of the
brightest candidates at z > 8 known (~ 0.3 mag brighter than the z = 8.68
galaxy EGSY8p7, spectroscopically confirmed by Zitrin and collaborators). For z
~ 9 candidates, we include previous data points at fainter magnitudes and find
that the data are well fitted by a Schechter luminosity function with alpha ~
-2.1, MUV ~ -21.5 mag, and log phi ~ -4.5 Mpc^-3mag^-1, for the first time
without fixing any parameters. The inferred cosmic star formation rate density
is consistent with unaccelerated evolution from lower redshift.Comment: 18pages, 7figures, 6tables. accepted to the Astrophysical Journa
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