24 research outputs found
Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders
Theories of autism spectrum disorders (ASD) have focused on altered perceptual integration
of sensory features as a possible core deficit. Yet, there is little understanding of the
neuronal processing of elementary sensory features in ASD. For typically developed individuals,
we previously established a direct link between frequency-specific neural activity
and the intensity of a specific sensory feature: Gamma-band activity in the visual cortex
increased approximately linearly with the strength of visual motion. Using magnetoencephalography
(MEG), we investigated whether in individuals with ASD neural activity reflect the
coherence, and thus intensity, of visual motion in a similar fashion. Thirteen adult participants
with ASD and 14 control participants performed a motion direction discrimination task
with increasing levels of motion coherence. A polynomial regression analysis revealed that
gamma-band power increased significantly stronger with motion coherence in ASD compared
to controls, suggesting excessive visual activation with increasing stimulus intensity
originating from motion-responsive visual areas V3, V6 and hMT/V5. Enhanced neural
responses with increasing stimulus intensity suggest an enhanced response gain in ASD.
Response gain is controlled by excitatory-inhibitory interactions, which also drive high-frequency
oscillations in the gamma-band. Thus, our data suggest that a disturbed excitatoryinhibitory
balance underlies enhanced neural responses to coherent motion in ASD
Influence of Dopaminergic Medication on Conditioned Pain Modulation in Parkinson's Disease Patients.
Pain is highly prevalent in patients with Parkinson's disease (PD), but little is known about the underlying pathophysiological mechanisms. The susceptibility to pain is known to depend on ascending and descending pathways. Because parts of the descending pain inhibitory system involve dopaminergic pathways, dysregulations in dopaminergic transmission might contribute to altered pain processing in PD. Deficits in endogenous pain inhibition can be assessed using conditioned pain modulation (CPM) paradigms.Applying such a paradigm, we investigated i) whether CPM responses differ between PD patients and healthy controls, ii) whether they are influenced by dopaminergic medication and iii) whether there are effects of disease-specific factors. 25 patients with idiopathic PD and 30 healthy age- and gender-matched controls underwent an established CPM paradigm combining heat pain test stimuli at the forearm and the cold pressor task on the contralateral foot as the conditioning stimulus. PD patients were tested under dopaminergic medication and after at least 12 hours of medication withdrawal.No significant differences between CPM responses of PD patients and healthy controls or between PD patients "on" and "off" medication were found. These findings suggest (i) that CPM is insensitive to dopaminergic modulations and (ii) that PD is not related to general deficits in descending pain inhibition beyond the known age-related decline. However, at a trend level, we found differences between PD subtypes (akinetic-rigid, tremor-dominant, mixed) with the strongest impairment of pain inhibition in the akinetic-rigid subtype.There were no significant differences between CPM responses of patients compared to healthy controls or between patients "on" and "off" medication. Differences between PD subtypes at a trend level point towards different pathophysiological mechanisms underlying the three PD subtypes which warrant further investigation and potentially differential therapeutic strategies in the future
Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults
BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.</p
Tic phenomenology and tic awareness in adults with autism
Background: Tics are common in people with autism spectrum disorder (ASD). However, their phenomenology and characteristics have not been studied in detail. Methods: Based on video sequences of 21 adults with ASD without intellectual disability and 16 adults with Gilles de la Tourette syndrome (GTS), tic severity, tic repertoires, and tic awareness were determined. Results: Ten ASD and all GTS participants had tics during video recordings. The ASD group had significantly fewer tics, compared to GTS. Tic distribution and tic repertoires were comparable, but more restricted in ASD. All GTS participants, but only 5 of the 10 ASD participants, were aware of their tics. Conclusions: Tics are common in adults with ASD. They are indistinguishable from tics in GTS and are similarly distributed, but less severe. Tic awareness is limited in ASD
The neural correlates of tic inhibition in Gilles de la Tourette syndrome
Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capacity were evaluated outside the scanner. Second, patients were examined with resting state functional magnetic resonance imaging (RS-fMRI) in two states, free ticcing and voluntary tic inhibition. Local synchronization of spontaneous fMRI-signal was analysed with regional homogeneity (ReHo) and differences between both states (free ticcing<tic inhibition) were contrasted. Clinical correlations of the resulting differential ReHo parameters between both states and clinical measures of tic frequency, voluntary tic inhibition and premonitory urges were also performed. ReHo of the left inferior frontal gyrus (IFG) was increased during voluntary tic inhibition compared to free ticcing. ReHo increases were positively correlated with participants׳ ability to inhibit their tics during scanning sessions but also outside the scanner. There was no correlation with ratings of premonitory urges. Voluntary tic inhibition is associated with increased ReHo of the left IFG. Premonitory urges are unrelated to this process.</p
Experimental protocol.
<p>This figure shows the experimental sequences of the conditioned pain modulation (CPM) paradigm used in this study (A = whole experiment, B = temporal components of trials). During block 1 and 3, the test stimulus (TS) was applied alone whereas during block 2 the TS and a conditioning stimulus (= cold pressor task using ice water; CS) were applied concurrently. Patients had to rate the pain intensity of TS and CS on a visual analogue scale (VAS).</p
Characteristics of PD patients.
<p>Patient characteristics regarding disease classification, symptom onset, medication and clinical scores such as UPDRS are shown for PD patients.</p><p>Characteristics of PD patients.</p
Mean CPM results of PD subtype.
<p>Mixed type (left), akinetic-rigid type (middle) and tremor-dominant type (left) in the “on” (light gray) and “off”(dark gray) condition (with standard errors of mean).</p
Data from: Stronger neural modulation by visual motion intensity in autism spectrum disorders
Theories of autism spectrum disorders (ASD) have focused on altered perceptual integration of sensory features as a possible core deficit. Yet, there is little understanding of the neuronal processing of elementary sensory features in ASD. For typically developed individuals, we previously established a direct link between frequency-specific neural activity and the intensity of a specific sensory feature: Gamma-band activity in the visual cortex increased approximately linearly with the strength of visual motion. Using magnetoencephalography (MEG), we investigated whether in individuals with ASD neural activity reflect the coherence, and thus intensity, of visual motion in a similar fashion. Thirteen adult participants with ASD and 14 control participants performed a motion direction discrimination task with increasing levels of motion coherence. A polynomial regression analysis revealed that gamma-band power increased significantly stronger with motion coherence in ASD compared to controls, suggesting excessive visual activation with increasing stimulus intensity originating from motion-responsive visual areas V3, V6 and hMT/V5. Enhanced neural responses with increasing stimulus intensity suggest an enhanced response gain in ASD. Response gain is controlled by excitatory-inhibitory interactions, which also drive high-frequency oscillations in the gamma-band. Thus, our data suggest that a disturbed excitatory-inhibitory balance underlies enhanced neural responses to coherent motion in ASD