Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystıc ovary syndrome

<p>Abstract</p> <p>Background</p> <p>Obesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients.</p> <p>In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study.</p> <p>Results</p> <p>In PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p> <p>Conclusions</p> <p>We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p

Epidemiology of pemphigus in Turkey: One-year prospective study of 220 cases

Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n=192; 87.3%), followed by pemphigus foliaceus (n=21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n=83; 43.2%). The mean Pemphigus Disease Area Index was 28.14±22.21 (mean ± Standard Deviation).  The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.   </p

Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study

Sleep disorders constitute an important public health problem. Prevalence of sleep disorders in Turkish adult population was investigated in a nationwide representative sample of 5021 Turkish adults (2598 women and 2423 men, response rate: 91%) by an interviewer‐administered questionnaire. Insomnia was defined by the DSM‐IV criteria, habitual snoring and risk for sleep‐related breathing disorders (SDB) by the Berlin questionnaire, excessive daytime sleepiness (EDS) by the Epworth sleepiness scale score, and restless legs syndrome (RLS) by the complaints according to the International Restless Legs Syndrome Study Group criteria. Mean age of the participants was 40.7 ± 15.1 (range 18 to 90) years. Prevalence rates (men/women) were insomnia 15.3% (10.5%/20.2%; P &lt; 0.001), high probability of SDB 13.7% (11.1%/20.2%; P &lt; 0.001), EDS 5.4% (5.0%/5.7%; P: 0.09), RLS 5.2% (3.0%/7.3%; P &lt; 0.001). Aging and female gender were associated with higher prevalence of sleep disorders except for habitual snoring. Prevalence rates of the sleep disorders among Turkish adults based on the widely used questionnaires were close to the lower end of the previous estimates reported from different parts of the world. These findings would help for the assessment of the health burden of sleep disorders and addressing the risk groups for planning and implementation of health care

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Adsorption of alpha-Picoline and gamma-Picoline on the Adsorbent Produced from Spent Bleaching Earth

Adsorbents were produced from spent bleaching earth and the individual adsorption of alpha-picoline and gamma-picoline by them was studied as a function of time, pH and initial concentration. The adsorption process for both solutes followed the first order Lagergren equation and the rate constants of the adsorption were calculated for each solute. Rate constants of intraparticle diffusion were also calculated for each solute. The adsorption capacities were obtained from the Langmuir isotherm. In order to understand adsorption mechanism, Giles isotherm was used and adsorption type for each solute was determined. Maximum adsorption capacity was observed between pH: 8.13 and 8.77

Adsorption of Carbamazepine on the Adsorbent Produced from Spent Bleaching Earth

The adsorption of carbamazepine on the adsorbent produced from spent bleaching earth was studied as a function of time, pH and initial concentration. The adsorption equilibrium was achieved within 1 h and the adsorption kinetics was found to obey the first-order Lagergren equation. The rate constants and intraparticle diffusion constants were calculated. It was seen that pH effect on the adsorption of carbamazepine is not very significant. It was concluded that activated carbon produced from spent bleaching earth can be considered as an effective adsorbent for removing carbamazepine

Adsorption of Carbamazepine on the Adsorbent Produced from Spent Bleaching Earth

The adsorption of carbamazepine on the adsorbent produced from spent bleaching earth was studied as a function of time, pH and initial concentration. The adsorption equilibrium was achieved within 1 h and the adsorption kinetics was found to obey the first-order Lagergren equation. The rate constants and intraparticle diffusion constants were calculated. It was seen that pH effect on the adsorption of carbamazepine is not very significant. It was concluded that activated carbon produced from spent bleaching earth can be considered as an effective adsorbent for removing carbamazepine

Functional Independence, Quality of Life, and Level of Mobility of Elderly People Living at Home and Nursing Home

Objective: To compare level of mobility, quality of life, and functional independence of the elderly people living at home and in the nursing homes

Palaeontological evidence and sedimentary facies in a lower Miocene (Aquitanian) succession from the Bingol minibasin (Sivas Basin), Central Anatolia

WOS: 000445963200001The results of palaeontological (palynological and mollusc) and sedimentological analyses of the lower Miocene deposits from the Bingol minibasin, a part of the Sivas Basin, are exhibited to define the vertical shifts in sedimentation environments and plant covers, linking to eustasy. The presence of index species Corbulomya (Lentidium) aquitanica suggests an Aquitanian age for the studied succession, which can be divided into three informal units: a lower unit, a middle unit, and an upper unit. Fine-grained sediments of the lower unit were deposited in a low sea-level setting due to high quantities of terrestrial palynomorphs. This unit is overlain by the middle unit, coralgal limestone, which marks the first initiation of Aquitanian transgression. Continuing shallow marine settings in the upper unit gave rise to deposition of coarse to fine-grained sediments. Palynological data were recovered from the fine-grained sediments of the lower and upper units. A total of 35 spore and pollen taxa were recorded, including 2 spores from ferns, 5 gymnosperms, 26 angiosperms, 1 group of undifferentiated dinoflagellate cysts, and 1 fresh water alga of Botryococcus sp. The pollen spectrum is dominated by coniferous forest, mainly undifferentiated Pinaceae, and herbaceous communities including high quantities of Poaceae and Chenopodiaceae-Amaranthaceae, with minor contributions of Ephedra sp., Caryophyllaceae, and Asteraceae subf. Asteroidae. High sea-level conditions, which started with sedimentation of the middle unit, survived during the deposition of the upper unit due to being overwhelmingly dominated by dinocysts. Thermophile plants including Avicennia sp., Engelhardia sp., Myrica sp., Sapotaceae, Cyrillaceae-Clethraceae, and Reveesia sp. along with relatively high quantities of xerophytes and the quantitative palaeoclimate values imply a subtropical and dry palaeoclimate.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109Y041]This study was supported by a research grant from the Scientific and Technological Research Council of Turkey (TUBITAK Grant No. 109Y041). The assistance provided by Mehmet Can Diyarbakirli, who took part in the fieldwork, is acknowledged. The authors would like to thank Ali Gurel, two anonymous reviewers, and the manuscript editor, Aysegul Yildiz, for their helpful comments

Biostratigraphic interpretation and systematics of Alveolina assemblages from the Ilerdian-Cuisian limestones of Southern Eskisehir, Central Turkey

The Ilerdian-Middle Cuisian sedimentary succession of the Seyitgazi region, southern Eskisehir (Central Anatolia, Turkey) is composed of claystones, limestones and clayey limestones. It contains abundant benthic foraminifera, particularly species of Alveolina. From this succession, 28 species of Alveolina d'Orbigny are described and their comparative stratigraphic distribution with the Alveolina species in the Tethyan Eocene is documented. Generally, Ilerdian-Cuisian Alveolina assemblages of the Seyitgazi region have close affinities with coeval Alveolina assemblages described in different studies from the Tethyan Province. The Ilerdian unit of the study area is characterized by Alveolina species such as Glomalveolina lepidula, Glomalveolina minutula, G. karsica, Alveolina vredenburgi, A. ellipsoidalis, A. avellana, A. aff. minervensis, A. dedolia, A. moussoulensis, A. subpyrenaica, A. laxa, A. aragonensis, A. varians, A. ilerdensis, A. trempina, A. citrea, A. pisella and A. decipiens. Likewise, the Early Middle Cuisian unit is represented by G. minutula, A. oblonga, A. schwageri, A. haymanensis, A. canavarii, A. aff. coudurensis, A. ruetimeyeri, A. muscatensis, A. cremae, A. bayburtensis and A. lehneri. (c) 2006 Elsevier Ltd. All rights reserved