Study of serum lipid profile in pregnancy induced hypertension in Benin City

Background: Pregnancy induced hypertension (P.I.H) continues to be a major obstetric problem in present day healthcare practice. At recent times, there has been a great interest on the role of lipid metabolism in the development of pregnancy induced hypertension and pre-eclampsia Objective: To evaluate the role of lipid profile in the ethiopathogenesis of pregnancy Induced hypertension and pre-eclampsia. Patients And Methods: A total of 60 subjects divided into 3 groups. The first group (n=20) were pregnant women with pregnancy induced hypertension, while the second group (n=20) were normontensive pregnant women and the last group (n=20) were non-pregnant normotensive women. All did not have previous history of chronic hypertension, thyroid disease, renal disease dislipidemia or diabetes mellitus. Serum triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol was measured. Results: Mean serum triglyceride was higher in (Group 1) pregnant women with pregnancy induced hypertension than in Groups 2 and 3, this was however not statistically significant(p>0.05). Mean total cholesterol was higher in group 1 and 2 compared with group 3 but was not statistically significant. HDL cholesterol was lowest in Group 1 compared with Groups 2 and 3, this was not statistically significant (p>0.05). LDL-cholesterol was similar in the 3 groups. Total cholesterol showed a statistically significant correlation with gestational age,(r=.550,p<0.05). Diastolic blood pressure showed a fairly strong negative correlation with HDL(r= -.494) which was statistically significant. (p<0.05) CONCLUSION: Women with pregnancy induced hypertension showed mild hypertriglyceridemia. Total cholesterol correlated significantly with gestational age in this group. HDL cholesterol correlated negatively with diastolic blood pressure which was statistically significant, while triglycerides, total cholesterol and LDL cholesterol correlated weakly with diastolic blood pressure. Keywords: Pregnancy induced hypertension (PIH), LDL-cholesterol, HDL-cholesterol, total cholesterol, triglycerid

Relationship Between Glycated Haemoglobin and Body Mass Index in a Healthy Population in Egor Local Government Area, Benin City

Context: Glycated haemoglobin is widely used as an index of mean glycemia, a measure of risk for the development of diabetic complications and quality of diabetes care. Obesity is commonly associated with type2 diabetes and has been shown to cause or aggravate insulin resistance.Objective: To determine the relationship between glycated hemoglobin and body mass index in an apparently healthy population in Egor local government area, Benin City.Methods: This is a cross sectional study involving healthy adults. Blood pressure, Height, Weight were all measured and body mass index (BMI) calculated as weight (in kilograms) divided by height (in meters squared). Glycated haemoglobin was estimated using the ion exchange chromatography method.Result: A total of 100 healthy subjects, 50 males and 50 females, ages ranging from 18 – 65 years were included in the study. Forty-six percent of the study population had BMI within the normal range, while theremaining subjects were either overweight (31%), obese (22%), morbidly obese (1%). BMI correlated significantly with Glycated haemoglobin (r=.330) (p < 0.05) in the study population. Correlation was stronger amongst the males (r=.456) (p< 0.05) than females, and was not statistically significant in the females (r=.319) (p> 0.05). BMI also showed a weak but significant correlation with diastolic blood pressure in the study population (r=.289) (p< 0.05).Conclusion: Glycated haemoglobin showed a significant correlation with body mass index in the population studied, corroborating the role obesity may play in the aietiopathogenesis of diabetes mellitus type 2 in thisenvironment.Key words: Glycated, haemoglobin, obesity, mass, inde

Glycated Haemoglobin In Healthy Adult Nigerians In Benin

Click on the link to view the abstract.The Tropical Journal of Health Sciences Vol 21 No 1 (January, 2014

Relationship between glycated Haemoglobin and glucose levels in adult healthy and diabeticNigerians in Benin Metropolis

Glycated haemoglobin, which is the non-enzymatic addition of a glucose molecule to one or both of the N-terminal valine of β chain of haemoglobin, is expressed as the percentage of adult haemoglobin that is glycated. Objective: To determine the relationship between fasting plasma glucose and glycated haemoglobin in a healthy and diabetic population in Benin City, Edo State and its relevance for use as a tool for monitoring control of diabetes. Patients And Methods: A total of 200 subjects participated in this study. One hundred of them were selected from a healthy adult population by simple random sampling and served as controls, while 100 were selected from diabetic patients attending outpatient clinic and on treatment. They were included in the study after meeting the inclusion criteria. Fasting plasma glucose and glycated haemoglobin were estimated in these subjects by the glucose oxidase method and cation- exchange chromatography method respectively. Results: Mean fasting plasma glucose was significantly increased in the diabetic population (149.8±72mg/dl), compared with the healthy population (81.mg/dl± 20mg/dl) (p = .001). Mean glycated haemoglobin was also significantly increased in the diabetic population (6.1± 2.8%), compared with the healthy population (4.9± 1.5%) (P = .000). Gender was observed to have a significant effect on glycated haemoglobin in both the healthy and the diabetic population (4.5 ± 1.1) (4.8 ± 1.1) p =.000 and (6.5±0.5) (5.6±0.4) p=.002, males and females respectively. There was significant correlation between fasting plasma glucose and glycated haemoglobin in both healthy and diabetic population (r = 0.369) (p =.000) (r = 0.315) (p = .001) Conclusion: We concluded that glycated haemoglobin correlated with fasting plasma glucose in the population studied, it may be used as a fairly accurate tool in assessing glycaemic control and monitoring treatment in diabetes mellitus. Keywords: Glycated haemoglobin, Fasting Plasma Glucos

Point of Care Testing: Knowledge and Utilization amongst Doctors in Government Hospitals in Edo State, Nigeria

Objective: The study assessed the knowledge and utilization of point of care testing (POCT) amongst doctors in two health facilities in Edo State, Nigeria.Methods: A descriptive cross‑sectional study was carried out using a multistage sampling technique. Data were collected from 174 doctors in both centers using a 25 item structured questionnaire which was analyzed using SPSS version 20.0.Result: The mean age of respondents was 31.26 ± 2.14 years with 120 (69.0%) males and 54 (31.0%) females (male: female = 2.2:1). Knowledge of POCT and utilization of POCT devices was good in 50.6% and 32.2% of respondents respectively. Utilization of POCT correlated significantly with knowledge of POCT (r = 0.67, P < 0.001) and availability of POCT devices (r = 0.43, P < 0.001). There was statistically significant association between utilization of POCT devices and Hospital (χ2 = 9.95, P = 0.002); job designation (χ2 = 10.03, P = 0.018) and availability of POCT devices (χ2 = 6.80, P = 0.001). However, no statistically significant relationship was found between utilization of POCT devices and sex (χ2 = 0.23, P = 0.629).Conclusion: Promotion of POCT’s utilization with regulation, training of doctors and establishment of regulatory framework/assessment teams will help improve healthcare services and achieve more beneficial outcomes. That way, POCT that is faster could be better.Keywords: Availability, Knowledge, Point of Care Testing, Utilizatio