Structural Features of TiNi-based Textile Materials and Their Biocompatibility with Cell Culture

This study investigates the structural features of TiNi-based textile materials. It is established that woven materials have a regular cellular structure, while knitted mesh materials are characterized by presence of cells with various sizes both in the longitudinal and cross directions. The surface oxide layer of threads has a microporous structure that provides the improved adaptation in organism tissues. It is shown that the fibroblast colonization rate of the knitted mesh implants depends on the cell size and quantity of mesh knots. Smaller cells are quicker colonized. Mesh knots are the centers of the cell cling. The feature of cell interaction with the tread surface of various sizes is analyzed

Regional Aspects of Nosocomial Infection As a Medical and Social Problem

Prevention of nosocomial infection (NI) is an important medical and socioeconomic problem. And though certain organizational and practical measures are implemented in Russia every year to reduce NIs, the problem is still relevant from medical and social points of view. The risk of infection are both for patients and medical workers. In Russia, the minimum economic damage caused by NIs is 2.5–5 billion rubles annually. According to the Office of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Republic of Mordovia, the total incidence of NI in the region is at a low level. The incidence rate was 0.01 per 1000 patients in hospitals. The dynamics of the last five years demonstrates a decrease in hospital-acquired infections. In the dynamics of the last five years, incidence rates of purulent-septic infections of newborns and postpartum women, postoperative purulent-septic complications and post-injection complications had an unstable downward trend. Thus, purulent-septic infections of newborns and postpartum women and postoperative infections are dominated in the structure of nosocomial infections. Analysis of dynamics of morbidity in recent years in the Republic of Mordovia suggests that the measures taken to prevent NI are quite effective and are manifested with consistently low rates

Effect of modified surface and architectonics of porous-permeable TiNi-based alloy scaffold on cellular biocompatibility

Cellular scaffolds based on porous biomaterials play an important role in the engineering of various tissues. Our porous-permeable cellular TiNi-based alloy scaffolds combine the advantages of metal structures, hardness, wear resistance and elasticity similar to that of human tissues. The aim of the research was the study on the change in the surface layer of samples from TiNi-based alloy and on the biotesting of modified samples with the 3H3 fibroblast line. Materials and methods: The biocompatibility of several samples of TiNi-based alloy scaffolds with an average pore size of 83,150,365 μm with modified (acid treatment) surface with 3H3 fibroblast line. Results. The porous-permeable cellular TiNi-based alloy scaffolds (average pore size = 150 μm) modified by treatment with solution of concentrated acids exhibited the highest biocompatibility with a fibroblast culture. It was shown that hemolysis of TiNi-based alloy samples, which are intact and treated with solution of concentrated acids, does not exceed 2 %. Direct cultivation of modified samples with fibroblast line in the cytotoxic test showed low cytotoxicity of the tested cells. The studies carried out using a scanning microscope showed that mesenchymal cells of bone marrow are attached in sufficient quantities to the microporous surface of the modified samples, which allows them to grow and proliferate in the pore space of TiNi-based alloy scaffolds and to cultivate tissue in vitro. Conclusion. Samples of scaffolds manufactured by the SHS-method and modified by treatment with concentrated solution of acids are technological and perspective biomaterial for their use as implantable clinically useful scaffolds

Міжпартійне протистояння євроатлантичній орієнтації в країнах Балтії

Кокорєв О. В. Міжпартійне протистояння євроатлантичній орієнтації в країнах Балтії / О. В. Кокорєв // S.P.A.C.E. Society, Politics, Administration in Central Europe : електронний науково-практичний журнал / редкол.: Д. В. Яковлев (голов. ред.), К. М. Вітман (заст. голов. ред.), Д. Ю. Дворніченко (відп. секр.) [та ін.] ; НУ «ОЮА». – Одеса, 2017. – Вип. 2. – С. 33-36.У статті проводиться аналіз особливостей політичних партій і їхніх можливостей із формування нової урядової коаліції. Проаналізовано зовнішньополітичне питання євроатлантичної орієнтації. Виявлено відмінності в оцінках зовнішньополітичного курсу.В статье проводится анализ особенностей политических партий и их возможностей по формированию новой правительственной коалиции. Проанализирован внешнеполитический вопрос евроатлантической ориентации. Выявлены различия в оценках внешнеполитического курса.The article analyzes the features of the political parties and the possibility of forming a new coalition government. It analyzes the foreign policy issue of Euro-Atlantic orientation. The differences in the estimates of foreign policy

Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide

Pancreas cages form a functional fabric and allocate hormonal substances necessary for indemnification of the lost structures of a pancreas of an organism. And, at input in an organism of ß-cells deprived of a substrate, life cycle transplanted xenogeneic cages considerably decreases under the influence of immune factors, during too time of a cage in an incubator function longer time, promoting construction of spatial architecture of new gland. The given methodology is effective in diabetes treatment as the transplanted cages it is very thin react to allocation of insulin depending on a condition homeostatic organism systems that is an actual problem at introduction of injections of insulin. Results of researches show that incubators of titanium nickelide are highly effective for their use as biocompatible matrixes. Features incubator spaces, and also a material titanium nickelide the titan promote creation fabric biosystems from various cages of an organism and to considerable prolongation of functional activity transplantation cages that accordingly conducts to increase in period of validity of therapeutic effect. Investigation have shown the formation of specific tissues in porous-permeable incubators of titanium nickelide for different cell populations. Allogeneic bone marrow cells immobilized in incubators of titanium nickelide possess antitumor (25%) and significant antimetastatic (45%) effect. The study of morphological parameters immunocompetent organs showed that administration of allogeneic bone marrow cells can decrease thymic regression, reduces splenomegaly in animals with transplantable tumors. Hepatocytes were implanted in porous materials of titanium nickelide mice with CCl4-induced hepatitis provided significant antitoxic effect. Obtained initial results promising pancreatic tissue-engineering in complex treatment of diabetes. It is noted that the use of incubators permeable porous nickel-titanium increase therapeutic effect and significantly prolongs effect of transplanted cells, as opposed their injecting

Combined transplantation of hepatocytes with mesenchimal stem cells of bone marrow on porous-permeable TiNi-based alloy scaffold

The aim of the research was to study of the therapeutic efficacy of combined transplantation of liver cells and mesenchymal stem cells of bone marrow (MSC) on TiNi-based alloy scaffolds of rats with chronic hepatitis. Materials and methods: Three groups of experiments were carried out on Wistar rats and intact rats (control) - I group; in the II group - chronic hepatitis; III group - cell-engineering designs with liver cells; in the IV group - cell-engineering designs with liver cells and BM MMSC. The activity of recovery processes was evaluated by using biochemical methods in dynamics on 10, 20, 30th days. Results. The optimal ratio of liver cells to MSC (5:1) was previously found in TiNi-based alloy scaffolds after transplantation and through co-cultivation of hepatocytes and MSC at different ratios. It was shown that recovery processes in the group with scaffolds transplanted into damaged livers were much more active if compared with those in the control group with chronic hepatitis. At the same time, in the group with combined transplantation on TiNi-based alloy scaffolds contributed to a more rapid normalization of liver enzyme indices compared with the group with transplantation of some hepatocytes on scaffolds. These data are confirmed by an increase in the life span of animals with combined hepatocytes and MSC transplantation on TiNi-based alloy scaffolds. Conclusions. A higher level and prolonged periods of liver regeneration during the transplantation of TiNi-based alloy scaffolds are due to the creation of biologically appropriate conditions for cells with certain ratio

COSMOS2020: The Galaxy Stellar Mass Function: the assembly and star formation cessation of galaxies at 0.2<z≤7.50.2\lt z \leq 7.5

How galaxies form, assemble, and cease their star-formation is a central question within the modern landscape of galaxy evolution studies. These processes are indelibly imprinted on the galaxy stellar mass function (SMF). We present constraints on the shape and evolution of the SMF, the quiescent galaxy fraction, and the cosmic stellar mass density across 90% of the history of the Universe from $z=7.5\rightarrow0.2$ via the COSMOS survey. Now with deeper and more homogeneous near-infrared coverage exploited by the COSMOS2020 catalog, we leverage the large 1.27 deg$^{2}$ effective area to improve sample statistics and understand cosmic variance particularly for rare, massive galaxies and push to higher redshifts with greater confidence and mass completeness than previous studies. We divide the total stellar mass function into star-forming and quiescent sub-samples through $NUVrJ$ color-color selection. Measurements are then fitted with Schechter functions to infer the intrinsic SMF, the evolution of its key parameters, and the cosmic stellar mass density out to $z=7.5$. We find a smooth, monotonic evolution in the galaxy SMF since $z=7.5$, in agreement with previous studies. The number density of star-forming systems seems to have undergone remarkably consistent growth spanning four decades in stellar mass from $z=7.5\rightarrow2$ whereupon high-mass systems become predominantly quiescent (i.e. downsizing). An excess of massive systems at $z\sim2.5-5.5$ with strikingly red colors, some newly identified, increase the observed number densities to the point where the SMF cannot be reconciled with a Schechter function. Systematics including cosmic variance and/or AGN contamination are unlikely to fully explain this excess, and so we speculate that there may be contributions from dust-obscured objects similar to those found in FIR surveys. (abridged)Comment: 39 pages, 24 figures, accepted for publication in A&A. Data files containing key measurements are available for download: https://doi.org/10.5281/zenodo.780883

Comparative study of cytotoxicity of ferromagnetic nanoparticles and magnetitecontaining polyelectrolyte microcapsules

The work was supported by Ministry of Education and Science of the Russian Federation as part of the State task for National Research Mordovia State University, project No. 2952 and the Government of the Russian Federation (grant №14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists

Strong (Hb + [OIII]) and Ha emitters at redshift z ~ 7-8 unveiled with JWST/NIRCam and MIRI imaging in the Hubble eXtreme Deep Field (XDF)

The JWST is revolutionizing the study of high-redshift galaxies by providing for the first time a high-sensitivity view of the early Universe at infrared wavelengths, both with its Near Infrared Camera (NIRCam) and Mid Infrared Instrument (MIRI). In this paper, we make use of medium and broad-band NIRCam imaging, as well as ultra-deep MIRI 5.6 microns imaging, in the Hubble eXtreme Deep Field (XDF) to identify prominent line emitters at z ~ 7-8. Out of a total of 58 galaxies at z ~ 7-8, we find 18 robust candidates (~31%) for prominent (Hb + [OIII]) emitters, based on their enhanced fluxes in the F430M and F444W filters, with rest-frame EW(Hb + [OIII]) ~ 87 - 2100 A. Among these emitters, 16 lie on the MIRI coverage area and 12 show a clear flux excess at 5.6 microns, indicating the simultaneous presence of a prominent Ha emission line with rest-frame EW(Ha) ~ 200 - 3000 A. This is the first time that Ha emission can be detected in individual galaxies at z>7. The Ha line, when present, allows us to separate the contributions of the Hb and [OIII] emission lines to the (Hb + [OIII]) complex and derive Ha-based star formation rates (SFRs). We find that in some cases [OIII]/Hb > 1, suggesting low metallicities, but a few have [OIII]/Hb < 1, so the NIRCam flux excess is mainly driven by Hb. The vast majority of prominent line emitters are very young starbursts or galaxies on their way to/from the starburst cloud. They make for a cosmic SFR density log10(SFRD_Ha / Msun yr^-1 Mpc^-3) ~ 2.35, which is about a third of the total value at z ~ 7-8. Therefore, the strong Ha emitters likely had an important role in reionization.Comment: 15 pages, 9 figures. Submitted to Ap