Is altitude training an efficient treatment for obesity?

Worldwide, about half the adult population is considered overweight as defined by a body mass index (BMI - calculated by body weight divided by height squared) ratio in excess of 25 kg.m-2. Of these individuals, half are clinically obese (with a BMI in excess of 30) and these numbers are still increasing, notably in developing countries such as those of the Middle East region. Obesity is a disorder characterised by increased mass of adipose tissue (excessive fat accumulation) that is the result of a systemic imbalance between food intake and energy expenditure. Although factors such as family history, sedentary lifestyle, urbanisation, income and family diet patterns determine obesity prevalence, the main underlying causes are poor knowledge about food choice and lack of physical activity3. Current obesity treatments include dietary restriction, pharmacological interventions and ultimately, bariatric surgery. The beneficial effects of physical activity on weight loss through increased energy expenditure and appetite modulation are also firmly established. Another viable option to induce a negative energy balance, is to incorporate hypoxia per se or combine it with exercise in an individual's daily schedule. This article will present recent evidence suggesting that combining hypoxic exposure and exercise training might provide a cost-effective strategy for reducing body weight and improving cardio-metabolic health in obese individuals. The efficacy of this approach is further reinforced by epidemiological studies using large-scale databases, which evidence a negative relationship between altitude of habitation and obesity. In the United States, for instance, obesity prevalence is inversely associated with altitude of residence and urbanisation, after adjusting for temperature, diet, physical activity, smoking and demographic factors

Near-field properties of plasmonic nanostructures with high aspect ratio

Using the Green's dyad technique based on cuboidal meshing, we compute the electromagnetic field scattered by metal nanorods with high aspect ratio. We investigate the effect of the meshing shape on the numerical simulations. We observe that discretizing the object with cells with aspect ratios similar to the object's aspect ratio improves the computations, without degrading the convergency. We also compare our numerical simulations to finite element method and discuss further possible improvements

Lazy Abstraction-Based Controller Synthesis

We present lazy abstraction-based controller synthesis (ABCS) for continuous-time nonlinear dynamical systems against reach-avoid and safety specifications. State-of-the-art multi-layered ABCS pre-computes multiple finite-state abstractions of varying granularity and applies reactive synthesis to the coarsest abstraction whenever feasible, but adaptively considers finer abstractions when necessary. Lazy ABCS improves this technique by constructing abstractions on demand. Our insight is that the abstract transition relation only needs to be locally computed for a small set of frontier states at the precision currently required by the synthesis algorithm. We show that lazy ABCS can significantly outperform previous multi-layered ABCS algorithms: on standard benchmarks, lazy ABCS is more than 4 times faster

Polarizing Double Negation Translations

Double-negation translations are used to encode and decode classical proofs in intuitionistic logic. We show that, in the cut-free fragment, we can simplify the translations and introduce fewer negations. To achieve this, we consider the polarization of the formul{\ae}{} and adapt those translation to the different connectives and quantifiers. We show that the embedding results still hold, using a customized version of the focused classical sequent calculus. We also prove the latter equivalent to more usual versions of the sequent calculus. This polarization process allows lighter embeddings, and sheds some light on the relationship between intuitionistic and classical connectives

KMOS LENsing Survey (KLENS) : morpho-kinematic analysis of star-forming galaxies at z∼2z \sim 2

We present results from the KMOS lensing survey-KLENS which is exploiting gravitational lensing to study the kinematics of 24 star forming galaxies at $1.4<z<3.5$ with a median mass of $\rm log(M_\star/M_\odot)=9.6$ and median star formation rate (SFR) of $\rm 7.5\,M_\odot\,yr^{-1}$. We find that 25% of these low-mass/low-SFR galaxies are rotation dominated, while the majority of our sample shows no velocity gradient. When combining our data with other surveys, we find that the fraction of rotation dominated galaxies increases with the stellar mass, and decreases for galaxies with a positive offset from the main sequence. We also investigate the evolution of the intrinsic velocity dispersion, $\sigma_0$, as a function of the redshift, $z$, and stellar mass, $\rm M_\star$, assuming galaxies in quasi-equilibrium (Toomre Q parameter equal to 1). From the $z-\sigma_0$ relation, we find that the redshift evolution of the velocity dispersion is mostly expected for massive galaxies ($\rm log(M_\star/M_\odot)>10$). We derive a $\rm M_\star-\sigma_0$ relation, using the Tully-Fisher relation, which highlights that a different evolution of the velocity dispersion is expected depending on the stellar mass, with lower velocity dispersions for lower masses, and an increase for higher masses, stronger at higher redshift. The observed velocity dispersions from this work and from comparison samples spanning $0<z<3.5$ appear to follow this relation, except at higher redshift ($z>2$), where we observe higher velocity dispersions for low masses ($\rm log(M_\star/M_\odot)\sim 9.6$) and lower velocity dispersions for high masses ($\rm log(M_\star/M_\odot)\sim 10.9$) than expected. This discrepancy could, for instance, suggest that galaxies at high-$z$ do not satisfy the stability criterion, or that the adopted parametrisation of the specific star formation rate and molecular properties fail at high redshift.Comment: Accepted for publication in A&A, 21 pages, 10 figure

Short- or long-rest intervals during repeated-sprint training in soccer?

The present study compared the effects of two repeated-sprint training (RST) programs, differing in duration of the between-sprint rest intervals, on various soccer-related exercise performances. For 5 weeks during the competitive season, twenty-nine young trained male soccer players either replaced two of their habitual fitness conditioning sessions with RST characterized by short (5-15; n = 9) or long (5-30; n = 10) rest intervals, or served as control (n = 10). The 5-15 and 5-30 protocols consisted of 6 repetitions of 30-m (~5 s) straight-line sprints interspersed with 15 s or 30 s of passive recovery, respectively. 5-15 improved 200-m sprint time (2.0±1.5%; p&lt;0.05) and had a likely positive impact on 20-m sprint performance, whereas 5-30 lowered the 20-m sprint time (2.7±1.6%; p&lt;0.05) but was only possibly effective for enhancing the 200-m sprint performance. The distance covered during the Yo-Yo Intermittent Recovery Test Level 2 increased following 5-15 (11.4±5.0%; p&lt;0.05), which was possibly better than the non-significant 6.5% enhancement observed in 5-30. Improvements in the total time of a repeated-sprint ability test were possibly greater following 5-30 (3.6±0.9%; p&lt;0.05) compared to 5-15 (2.6±1.1%; p&lt;0.05). Both RST interventions led to similar beneficial (p&lt;0.05) reductions in the percentage decrement score (~30%) of the repeated-sprint ability test as well as in blood lactate concentration during submaximal exercise (17-18%). No changes occurred in the control group. In soccer players, RST over a 5-week in-season period is an efficient means to simultaneously develop different components of fitness relevant to match performance, with different benefits induced by shorter compared to longer rest intervals

Multi-Modal Courtship in the Peacock Spider, Maratus volans (O.P.-Cambridge, 1874)

The peacock spider, Maratus volans, has one of the most elaborate courtship displays in arthropods. Using regular and high-speed video segments captured in the lab, we provide detailed descriptions of complete male courtship dances. As research on jumping spiders has demonstrated that males of some species produce vibrations concurrently with visual displays, we also used laser vibrometry to uncover such elements for this species. Our recordings reveal and describe for the first time, that M. volans males use vibratory signals in addition to complex body ornaments and motion displays. The peacock spider and other closely related species are outstanding study organisms for testing hypotheses about the evolution and functional significance of complex displays, thus, this descriptive study establishes a new model system for behavioral ecology, one that certainly stands to make important contributions to the field

Online and offline representations of biocultural diversity: A political ecology perspective on nature-based tourism and indigenous communities in the Brazilian Pantanal

The concept of biocultural diversity is confronted with contemporary changes that impact on local communities, such as globalization and digital transformations. Engaging the conceptual flexibility of ‘biocultural diversity’, we studied nature-based tourism at the intersection of indigenous communities and the digital realm. We employed a political ecology perspective to examine online and offline representations of biocultural diversity in the Brazilian Pantanal, one of the biggest wetlands in the world, and home to groups of peoples known as the Pantaneiros. Data from interviews with 48 stakeholders in the tourist sector were structured along three ‘myths’—the Uncivilised, Unrestrained, and Unchanged—for which we have also constructed counter narratives. Each myth denoted the primacy of biodiversity, and ignored broader dimensions of the Pantanal as a bioculturally diverse landscape. The relationships of the Pantaneiros with their environment were found to be intricate and had clear repercussions for tourism, but ironically, reference to the Pantaneiro culture in nature-based tourism was superficial. Moreover, thriving on the myths, this form of tourism perpetuates skewed power structures and social inequalities. Lower-class Pantaneiros likely suffer most from this. We recommend stakeholder engagement with a biocultural design that facilitates the integration of other-than-biodiversity values, and that thereby promotes sustainability of the entire social-ecological system

Development Of Innovating Na Leak Detector On Pipes

International audienceWithin the ASTRID reactor project, CEA, EDF and AREVA NP, have launched a RetD program focused on the low leak rates detection of sodium on pipes. This program is focused on the development of innovating detectors, multilayer-type and Optic Fiber, involving tests in the FUTUNa sodium loop. This loop is designed to produce very accurate sodium leak rates within a range around 1cm$^3$/min, the tests being performed at different temperature (up to 550DC) on large-diameter pipe mock-ups (D 800 mm) at ambient atmosphere. This paper presents the first series of tests carried out with various materials of the first and second layer of the detector. The results are compared and discussed as well as the observations made after removing the mock-ups. The most interesting result of the overall tests is a detection time less than 2 hours for the two types of detectors

Primary beam effects of radio astronomy antennas -- II. Modelling the MeerKAT L-band beam

After a decade of design and construction, South Africa's SKA-MID precursor MeerKAT has begun its science operations. To make full use of the widefield capability of the array, it is imperative that we have an accurate model of the primary beam of its antennas. We have taken available L-band full-polarization 'astro-holographic' observations of three antennas and a generic electromagnetic simulation and created sparse representations of the beams using principal components and Zernike polynomials. The spectral behaviour of the spatial coefficients has been modelled using discrete cosine transform. We have provided the Zernike-based model over a diameter of 10 deg averaged over the beams of three antennas in an associated software tool (EIDOS) that can be useful in direction-dependent calibration and imaging. The model is more accurate for the diagonal elements of the beam Jones matrix and at lower frequencies. As we get more accurate beam measurements and simulations in the future, especially for the cross-polarization patterns, our pipeline can be used to create more accurate sparse representations of MeerKAT beams.Comment: 16 pages, 18 figures. This is a pre-copyedited, author-produced PDF of an article accepted for publication in MNRAS following peer review. The version of record [K. M. B. Asad et al., 2021] is available online at: https://doi.org/10.1093/mnras/stab10