Progressive modulation of resting-state brain activity during neurofeedback of positive-social emotion regulation networks

Neurofeedback allows for the self-regulation of brain circuits implicated in specific maladaptive behaviors, leading to persistent changes in brain activity and connectivity. Positive-social emotion regulation neurofeedback enhances emotion regulation capabilities, which is critical for reducing the severity of various psychiatric disorders. Training dorsomedial prefrontal cortex (dmPFC) to exert a top-down influence on bilateral amygdala during positive-social emotion regulation progressively (linearly) modulates connectivity within the trained network and induces positive mood. However, the processes during rest that interleave the neurofeedback training remain poorly understood. We hypothesized that short resting periods at the end of training sessions of positive-social emotion regulation neurofeedback would show alterations within emotion regulation and neurofeedback learning networks. We used complementary model-based and data-driven approaches to assess how resting-state connectivity relates to neurofeedback changes at the end of training sessions. In the experimental group, we found lower progressive dmPFC self-inhibition and an increase of connectivity in networks engaged in emotion regulation, neurofeedback learning, visuospatial processing, and memory. Our findings highlight a large-scale synergy between neurofeedback and resting-state brain activity and connectivity changes within the target network and beyond. This work contributes to our understanding of concomitant learning mechanisms post training and facilitates development of efficient neurofeedback training

Russian University Teachers’ Ethical Culture Regulation

Based on a review of publications of Russian and foreign researchers, the authors highlight the most significant topics on the deontology of university life. The article presents the results of an analysis of the texts of ethical codes of some leading universities in Russia (National Research University Higher School of Economics, Moscow State University, St. Petersburg State University, Kazan Federal University, Ural Federal University), as well as the results of an online survey (N = 297) of teachers of these universities. The survey was conducted to study the attitude of the teaching staff towards the tools for standardizing the moral culture of universities and the implementation of the values enshrined in the ethical standards of universities and ideals of academic community. Conclusions are made about the ethical attitudes of teachers and the effectiveness of moral regulation, as well as proposals for improving the ethical codes of universities are made

Кібербезахист у цифровому навчальному середовищі: зовнішні та внутрішні ризики

The paper describes a novel project aimed at developing the concept and technique of cyber safety system of the education process’ participants in the digital learning environment (integration of human and cyber-physical systems approach). A striking feature of the proposed approach lies in its notable difference from the one and focus on a human in the network’s cybersecurity loop rather than technical aspects or human personal data. Besides, it discusses the method and way of conducting experimental studies.У статті описано новий проект, спрямований на розробку концепції та техніки системи кіберзахисту учасників навчального процесу в цифровому навчальному середовищі (інтеграція людського та кібер-фізичного системного підходу). Принциповою особливістю запропонованого підходу є його помітна відмінність від інших підходів і спрямованість на людину в контурі кібербезпеки мережі, а не на технічних аспектах чи персональних даних людини. Крім того, обговорюється методика та спосіб проведення експериментальних досліджень

Phylogeny and Diversification Patterns among Vesicomyid Bivalves

Vesicomyid bivalves are among the most abundant and diverse symbiotic taxa in chemosynthetic-based ecosystems: more than 100 different vesicomyid species have been described so far. In the present study, we investigated the phylogenetic positioning of recently described vesicomyid species from the Gulf of Guinea and their western Atlantic and Pacific counterparts using mitochondrial DNA sequence data. The maximum-likelihood (ML) tree provided limited support for the recent taxonomic revision of vesicomyids based on morphological criteria; nevertheless, most of the newly sequenced specimens did not cluster with their morphological conspecifics. Moreover, the observed lack of geographic clustering suggests the occurrence of independent radiations followed by worldwide dispersal. Ancestral character state reconstruction showed a significant correlation between the characters “depth” and “habitat” and the reconstructed ML phylogeny suggesting possible recurrent events of ‘stepwise speciation’ from shallow to deep waters in different ocean basins. This is consistent with genus or species bathymetric segregation observed from recent taxonomic studies. Altogether, our results highlight the need for ongoing re-evaluation of the morphological characters used to identify vesicomyid bivalves

INFLUENCE OF HEAT TREATMENT ON THE STRUCTURAL AND MECHANICAL CHARACTERISTICS OF STEELS FOR THE MANUFACTURE OF MOLDS OF INJECTION MOLDING

Приведен сравнительный анализ сложнолегированных штамповых сталей инструментального класса с целью замены стали 4Х4МВФС, применяемой в настоящее время для изготовления пуансона машины литья под давлением, на более перспективную разработанную сталь 70Х3Г2ФТР.A comparative analysis of complex alloyed die steels tool class to replace steel 4Х4МВФС, currently used for the manufacture of the punch machine die casting for the more promising of the developed steel 70Х3Г2ФТР

Влияние реактогенности вакцин против клещевого энцефалита на иммунный ответ у вакцинированных людей

In present review the connection of the reactogenity of tick-borne encephalitis (TBE) vaccines not only with high content of the alien proteins, but also with content of the specific antigen for TBE virus was shown. By the example of vaccine «Encepur Adult» (Germany), containing neither polygeline and human serum albumin, feebly marked postvaccinal reactions was considered as positive fact, essentially influencing on the activity of the specific immune response.В настоящем обзоре показана связь реактогенности вакцин против клещевого энцефалита не только с повышенным содержанием чужеродных белков, но и с содержанием специфического антигена вируса клещевого энцефалита. На приме- ре немецкой вакцины «Энцепур взрослый», не содержащей полижелина и человеческого альбумина, слабо выраженные поствакцинальные реакции рассматриваются как положительный факт, существенно влияющий на активность специфиче- ского иммунного ответа

Detection of Apoptosis in Cancer Cells Using Heat Shock Protein 70 and p53 Antibody Conjugated Quantum Dot Nanoparticles

Clinical experience indicates that enhanced level of heat shock protein 70 (Hsp70) and p53 correlates with poor prognosis due to malignant cell overexpression of these proteins in tumor progression. Cadmium selenide quantum dots (QDs) were synthesized in aqueous solution using mercaptopropionic acid and L-cysteine (L-Cys) as ligands. They were conjugated with a monoclonal antibody (Ab) to p53 and cmHp70.1 to Hsp70 for detection of cancer cell apoptosis that was demonstrated in the experiment by fluorescent confocal microscopy both for breast carcinoma cells and for thyroid tissue. It is shown that in comparison with organic dyes, quantum dots have superior photostability of tracking apoptosis in cancer cells for longer time

Thermal effects of carbonated hydroxyapatite modified by glycine and albumin

In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydration, decarboxylation and thermal degradation of amino acid and protein connected to the surface of solid phase occur. The tendency of temperature lowering of the decomposition of powders synthesized from a medium containing organic substances was determined. Results demonstrate a direct dependence between the concentration of the amino acid in a model solution and its content in the solid phase