Homogeneous comparison of planet candidates imaged directly until 2008

We present a compilation of the planet candidates currently known from direct imaging. We have gathered available data from the literature and derive the luminosity of all candidates in a homogeneous way using a bolometric correction, the distances and the K band magnitudes of the objects. In a final step we find the masses of the candidates from a comparison of the luminosity or, if not available, an absolute brightness and several well known hot-start evolutionary models.Comment: 4 pages, 1 figure, Proceedings of the 2nd Subaru International Conference on Exoplanets and Disks: Their Formation and Diversity, Keauhou - Hawaii - USA, 9-12 March 2009; 2nd version: Several typos correcte

Long-distance entanglement-based quantum key distribution over optical fiber

We report the first entanglement-based quantum key distribution (QKD) experiment over a 100-km optical fiber. We used superconducting single photon detectors based on NbN nanowires that provide high-speed single photon detection for the 1.5-µm telecom band, an efficient entangled photon pair source that consists of a fiber coupled periodically poled lithium niobate waveguide and ultra low loss filters, and planar lightwave circuit Mach-Zehnder interferometers (MZIs) with ultra stable operation. These characteristics enabled us to perform an entanglement-based QKD experiment over a 100-km optical fiber. In the experiment, which lasted approximately 8 hours, we successfully generated a 16 kbit sifted key with a quantum bit error rate of 6.9 % at a rate of 0.59 bits per second, from which we were able to distill a 3.9 kbit secure key

ヒト角化上皮細胞における5-FU誘発性酸化ストレスおよび炎症応答に対するresveratrolの保護効果

Although 5-fluorouracil (5-FU) is currently used as an anti-cancer chemotherapy, adverse effects such as oral mucositis potentially limit its clinical application. Additionally, the prevention of 5-FU-induced side effects are scarce. Resveratrol is known to decrease oxidative damage and inflammation. In this study, we examined the protective effects of resveratrol on 5-FU-induced oxidative stress and inflammatory responses in normal human keratinocytes (HaCaT cell) as in vitro oral mucositis model. HaCaT cells were exposed to 5-FU and simultaneously treated with resveratrol. The effects of resveratrol on 5-FU-induced cytotoxicity were evaluated using cell viability assay. The production of reactive oxygen species (ROS) was measured using a fluorescence spectrophotometer. The effects of resveratrol on nuclear factor erythroid 2-related factor 2 (Nrf2), silent information regulator transcript-1 (SIRT-1), and nuclear factor kappa B (NF-κB) signaling and inflammatory cytokine expression were examined. Resveratrol suppressed 5-FU-induced overproduction of ROS by upregulating anti-oxidant defense genes through Nrf2 activation and SIRT-1 expression. Concerning inflammatory responses, resveratrol suppressed the 5-FU-induced expression of pro-inflammatory cytokines via NF-κB nuclear translocation. Conversely, N-acetylcysteine reduced ROS levels without affecting the expression of pro-inflammatory cytokines. Resveratrol might be useful for preventing 5-FU-induced adverse effects by activating anti-oxidant and anti-inflammatory responses

Thermodynamics of C incorporation on Si(100) from ab initio calculations

We study the thermodynamics of C incorporation on Si(100), a system where strain and chemical effects are both important. Our analysis is based on first-principles atomistic calculations to obtain the important lowest energy structures, and a classical effective Hamiltonian which is employed to represent the long-range strain effects and incorporate the thermodynamic aspects. We determine the equilibrium phase diagram in temperature and C chemical potential, which allows us to predict the mesoscopic structure of the system that should be observed under experimentally relevant conditions.Comment: 5 pages, 3 figure

Fusion of the qq-Vertex Operators and its Application to Solvable Vertex Models

We diagonalize the transfer matrix of the inhomogeneous vertex models of the 6-vertex type in the anti-ferroelectric regime intoducing new types of q-vertex operators. The special cases of those models were used to diagonalize the s-d exchange model\cite{W,A,FW1}. New vertex operators are constructed from the level one vertex operators by the fusion procedure and have the description by bosons. In order to clarify the particle structure we estabish new isomorphisms of crystals. The results are very simple and figure out representation theoretically the ground state degenerations.Comment: 35 page

Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels — “ABC method”

The current status of screening for gastric cancer-risk (gastritis A, B, C, D) method using combined assay for serum anti-Helicobacter pylori (Hp) IgG antibody and serum pepsinogen (PG) levels, “ABC method”, was reviewed and the latest results of our ongoing trial are reported. It was performed using the following strategy: Subjects were classified into 1 of 4 risk groups based on the results of the two serologic tests, anti-Hp IgG antibody titers and the PG I and II levels: Group A [Hp(−)PG(−)], infection-free subjects; Group B [Hp(+)PG(−)], chronic atrophic gastritis (CAG) free or mild; Group C [Hp(+)PG(+)], CAG; Group D [Hp(−)PG(+)]), severe CAG with extensive intestinal metaplasia. Continuous endoscopic follow-up examinations are required to detect early stages of gastric cancer. Asymptomatic Group A, which accounts for 50–80% of all the subjects may be excluded from the secondary endoscopic examination, from the viewpoint of efficiency. Hp-infected subjects should be administered eradication treatment aimed at the prevention of gastric cancer

Quantum Algebraic Approach to Refined Topological Vertex

We establish the equivalence between the refined topological vertex of Iqbal-Kozcaz-Vafa and a certain representation theory of the quantum algebra of type W_{1+infty} introduced by Miki. Our construction involves trivalent intertwining operators Phi and Phi^* associated with triples of the bosonic Fock modules. Resembling the topological vertex, a triple of vectors in Z^2 is attached to each intertwining operator, which satisfy the Calabi-Yau and smoothness conditions. It is shown that certain matrix elements of Phi and Phi^* give the refined topological vertex C_{lambda mu nu}(t,q) of Iqbal-Kozcaz-Vafa. With another choice of basis, we recover the refined topological vertex C_{lambda mu}^nu(q,t) of Awata-Kanno. The gluing factors appears correctly when we consider any compositions of Phi and Phi^*. The spectral parameters attached to Fock spaces play the role of the K"ahler parameters.Comment: 27 page

Magnetocaloric and Magnetic Properties of Ni\u3csub\u3e2\u3c/sub\u3eMn\u3csub\u3e1-x\u3c/sub\u3eCu\u3csub\u3ex\u3c/sub\u3eGa Heusler Alloys: an Insight from the Direct Measurements and \u3ci\u3eab initio\u3c/i\u3e and Monte Carlo Calculations

We calculated magnetic exchange constants and magnetocaloric properties of Ni2Mn1-xCuxGa Heusler alloys by ab initio and Monte Carlo methods. The ab initio study of the influence of the Cu excess x on the strength of magnetic interactions revealed that Cu weakens Mn-Ni interaction and has a complex impact on the Mn-Mn interactions. Theoretically calculated magnetic phase diagram of Ni2Mn1-xCuxGa is in a good agreement with available experimental data. Calculated by the Monte Carlo method the isothermal magnetic entropy change Delta Smag in a Ni2Mn0.75Cu0.25Ga alloy is significantly smaller around the coupled magnetostructural phase transition temperature than the reported earlier experimental Delta Smag. This discrepancy is ascribed to an overestimation of the experimental Delta Smag at the magnetostructural phase transition. Theoretically determined adiabatic temperature change Delta Tad in Ni2Mn0.75Cu0.25Ga agrees well with Delta Tad measured experimentally by a direct method

Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309–449). Patients with serum soluble Klotho levels below the lower quartile (<309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29–13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model

AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2]. Multiple FGFR2 splice variants are generated through alternative splicing, including PTC (premature termination codon)-containing transcripts that are normally eliminated via the NMD (nonsense-mediated decay) pathway. We have discovered that a soluble truncated FGFR2 molecule encoded by a PTC-containing transcript is up-regulated and persists in tissues of an AS mouse model. We have termed this IIIa–TM as it arises from aberrant splicing of FGFR2 exon 7 (IIIa) into exon 10 [TM (transmembrane domain)]. IIIa–TM is glycosylated and can modulate the binding of FGF1 to FGFR2 molecules in BIAcore-binding assays. We also show that IIIa–TM can negatively regulate FGF signalling in vitro and in vivo. AS phenotypes are thought to result from gain-of-FGFR2 signalling, but our findings suggest that IIIa–TM can contribute to these through a loss-of-FGFR2 function mechanism. Moreover, our findings raise the interesting possibility that FGFR2 signalling may be a regulator of the NMD pathway