Influence of prosthesis design and implantation technique on implant stresses after cementless revision THR

BACKGROUND: Femoral offset influences the forces at the hip and the implant stresses after revision THR. For extended bone defects, these forces may cause considerable bending moments within the implant, possibly leading to implant failure. This study investigates the influences of femoral anteversion and offset on stresses in the Wagner SL revision stem implant under varying extents of bone defect conditions. METHODS: Wagner SL revision stems with standard (34 mm) and increased offset (44 mm) were virtually implanted in a model femur with bone defects of variable extent (Paprosky I to IIIb). Variations in surgical technique were simulated by implanting the stems each at 4 degrees or 14 degrees of anteversion. Muscle and joint contact forces were applied to the reconstruction and implant stresses were determined using finite element analyses. RESULTS: Whilst increasing the implant's offset by 10 mm led to increased implant stresses (16.7% in peak tensile stresses), altering anteversion played a lesser role (5%). Generally, larger stresses were observed with reduced bone support: implant stresses increased by as much as 59% for a type IIIb defect. With increased offset, the maximum tensile stress was 225 MPa. CONCLUSION: Although increased stresses were observed within the stem with larger offset and increased anteversion, these findings indicate that restoration of offset, key to restoring joint function, is unlikely to result in excessive implant stresses under routine activities if appropriate fixation can be achieved

Investigation of overall and melamine migration from melamine bowls

Overall and melamine migration have been determined for 60 samples of melamine resin bowls, which were purchased in various local markets in the area of Bursa, Turkey. The samples were exposed to food simulants 3% acetic acid, 10% ethanol aqueous solutions, and rectified (refined) olive oil at 100 °C for 30 min, and 50% ethanol aqueous solutions at 60 °C for 30 min. The LOQ value was calculated as 3.3 mg dm−2 for overall migration and 0.126 mg kg-1 for melamine migration. Research findings did not exceed the limit of overall migration level (10 mg dm−2). Also, melamine levels of all tested items found in the third assays were below the specific migration limit (SML) of 2.5 mg kg−1 set out in the EU 10/2011 (EU, 2011) and Turkish Food Codex 2013/34 (TFC, 2013a). Some expensive as well as cheap products showed close migration levels. The increased cost of the item did not indicate a higher quality regarding health in this study

Detecting Primary Progressive Aphasia Atrophy Patterns: A Comparison of Visual Assessment and Quantitative Neuroimaging Techniques

BACKGROUND: There are now clinically available automated MRI analysis software programs that compare brain volumes of patients to a normative sample and provide OBJECTIVE: To address this gap in the literature, we examined Neuroreader METHODS: lvPPA or aMCI patients who underwent MRI with Neuroreader RESULTS: Cohen\u27s Kappa coefficients were significant in 10 of the 28 computations ( CONCLUSION: Overall, our results indicated moderate to low interrater reliability, and raters never agreed that left asymmetry was present. While lowe

İş hukukunda uzman arabuluculuk

Alternatif uyuşmazlık çözüm yollarından biri olan arabuluculuk, esasında öteden beri var olan, özünde uzlaşma kültürünü barındıran ve geçmişimizde de uygulanan bir sistemdir. Ahilik teşkilatı 800 yıl öncesinden başlamak üzere esnaflarımız arasında barışa katkı sağla-mıştır. Ülkemizde ise 2013 yılında ihtiyari olarak uygulanmaya başlanan ve uyuşmazlıkla-rın daha az masrafla ve daha hızlı sürede çözümlenmesini sağlayan bir alternatif uyuşmazlık yöntemi olan arabuluculuğun son yıllarda farkındalığı artmış ve kullanımı yaygınlaşmıştır. 2018 yılında öncelikle iş uyuşmazlıklarında, 2019 yılında ticari uyuşmazlıklarda ve son olarak 2020 yılında tüketici uyuşmazlıklarında dava şartı sisteminin getirilmesi ile birlikte, uyuşmazlıkların taraf iradelerine uygun olarak, kazan-kazan esasına dayalı bir biçimde çö-zülmesi ve mahkemelerdeki dosya yükünün azaltılmasının yanı sıra arabuluculuğun vatan-daşlarımız ve iş dünyası nezdinde benimsenmesi sağlanarak ülkemizde uzlaşı kültürünün oluşturulmasına da önemli ölçüde katkı sunulmuştur. Öte yandan; hukuk sistemimizde dava şartı arabuluculuk sisteminin yaygınlaştırılması, uyuşmazlıkların türüne göre ilgili alanlarda uzman arabulucular desteğiyle çözümlenmesini gerekli kılmıştır. Arabuluculuk uygulamasında bir karar mercii olmamakla birlikte arabulu-cunun görev aldığı uyuşmazlık alanında uzmanlığa sahip olması, taraflar bakımından olduğu kadar arabulucunun kendisi bakımından da faydalı olacak, özellikle tarafların tıkandığı nok-tada olumlu ve yapıcı bir çözüm önerisi geliştirmesine ve arabuluculuk sürecinin anlaşma ile sonuçlanmasına yardımcı olacaktır. Bu amaçla; öncelikle iş hukukunda uzman arabulucu uygulamasına geçilmiş, iş uyuşmaz-lıklarında görev alabilmek için söz konusu alanda gerekli eğitimleri almak arabulucular için ön şart haline getirilmiştir

Divergent in situ expression of IL-31 and IL-31RA between bullous pemphigoid and pemphigus vulgaris

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two major autoimmune blistering skin diseases. Unlike PV, BP is accompanied by intense pruritus, suggesting possible involvement of the pruritogenic cytokine IL-31. However, the underlying mechanisms of the clinical difference between BP and PV in terms of pruritus are not fully understood. To compare the expression levels of IL-31 and its receptor IL-31RA in the lesional skin, including peripheral nerves in BP and PV patients, immunohistochemical staining for IL-31 and IL-31RA was performed in skin samples of BP and PV patients and healthy controls (HC). The IL-31RA-expressing area in epidermis and peripheral nerves was analysed using ImageJ and the percentage of positive cells for IL-31/IL-31RA in dermal infiltrating cells was manually quantified. Quantitative analyses revealed that IL-31/IL-31RA expressions in the epidermis and dermal infiltrate were significantly increased in BP compared to PV and HC. The difference between BP and PV became more obvious when advanced bullous lesions were compared. Peripheral nerves in BP lesions presented significantly higher IL-31RA expression compared to PV lesions. In conclusion, we found significantly augmented expressions of IL-31/IL-31RA in BP lesions, including peripheral nerves, in comparison to PV. These results suggest a possible contribution of IL-31/IL-31RA signalling to the difference between BP and PV in the facilitation of pruritus and local skin inflammation, raising the possibility of therapeutic targeting of the IL-31/IL-31RA pathway in BP patients

Performance Analysis of Space-Time Block Codes in Flat Fading MIMO Channels with Offsets

We consider the effect of imperfect carrier offset compensation on the performance of space-time block codes. The symbol error rate (SER) for orthogonal space-time block code (OSTBC) is derived here by taking into account the carrier offset and the resulting imperfect channel state information (CSI) in Rayleigh flat fading MIMO wireless channels with offsets.https://doi.org/10.1155/2007/3054

Integration of evidence across human and model organism studies: A meeting report.

The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting\u27s objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and \u27omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. Linkage disequilibrium score regression of 220 cell types implicated the regulation of myeloid gene expression in AD risk. The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macrophages. SPI1 encodes PU.1, a transcription factor critical for myeloid cell development and function. AD heritability was enriched within the PU.1 cistrome, implicating a myeloid PU.1 target gene network in AD. Finally, experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells. Our results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function