88 research outputs found
Beam-Normal Single Spin Asymmetry in Elastic Electron Scattering off Si and Zr
We report on a new measurement of the beam-normal single spin asymmetry
in the elastic scattering of 570 MeV transversely polarized
electrons off Si and Zr at . The
studied kinematics allow for a comprehensive comparison with former results on
C. No significant mass dependence of the beam-normal single spin
asymmetry is observed in the mass regime from C to Zr.Comment: Submitted for publication to Physics Letters
Quasi-elastic polarization-transfer measurements on the deuteron in anti-parallel kinematics
We present measurements of the polarization-transfer components in the
H reaction, covering a previously unexplored kinematic
region with large positive (anti-parallel) missing momentum, , up
to 220 MeV, and . These measurements, performed
at the Mainz Microtron (MAMI), were motivated by theoretical calculations which
predict small final-state interaction (FSI) effects in these kinematics, making
them favorable for searching for medium modifications of bound nucleons in
nuclei. We find in this kinematic region that the measured
polarization-transfer components and and their ratio agree with the
theoretical calculations, which use free-proton form factors. Using this, we
establish upper limits on possible medium effects that modify the bound
proton's form factor ratio at the level of a few percent. We also
compare the measured polarization-transfer components and their ratio for H
to those of a free (moving) proton. We find that the universal behavior of
H, He and C in the double ratio
is maintained in the positive
missing-momentum region
High accuracy synchrotron radiation interferometry with relativistic electrons
A high-precision hypernuclear experiment has been performed at the Mainz
Microtron (MAMI) to determine the hypertriton {\Lambda} binding energy via
decay-pion spectroscopy. A key element of this measurement is an accurate
calibration of the magnetic spectrometers with the MAMI beam. For such an
absolute calibration with small statistical and systematic uncertainties the
undulator light interference method will be applied. In this contribution the
basic principle of this method is discussed and the analysis status of the
measured synchrotron radiation spectra is presentedComment: The 13th Biennial Conference on Classical and Quantum Relativistic
Dynamics of Particles and Fields (IARD22
Measurement of polarization transfer in the quasi-elastic process
Polarization transfer to a bound proton in polarized electron knock-out
reactions, , is a powerful tool to look
for in-medium modification of the bound proton. It requires comparison to
calculations which consider the many-body effects accompanying the quasi-free
process. We report here measured components , , and
their ratio , of polarization transfer to protons
bound in , which is described well by the shell model and for
which reliable calculations are available. While the calculations capture the
essence of the data, our statistical precision allows us to observe deviations
which cannot be explained by simple scaling, including by varying the proton
electromagnetic form factor ratio . We further explore the deviations
of the ratio of the polarization transfer components from that of a free
proton, , and its dependence on the bound-proton virtuality
Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)
Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10-8), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD
Meta-analysis of type 2 Diabetes in African Americans Consortium
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR) = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe
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