Resonant production of diquarks at high energy pp, ep and e+e- colliders

Resonant productions of the first generation scalar and vector diquarks at high energy hadron-hadron (pp), lepton-hadron (ep) and lepton-lepton (e+e-) colliders are investigated. Taking into account the hadronic component of the photon, diquarks can be produced resonantly in the lepton-hadron and lepton-lepton collisions. Production rates, decay widths and signatures of diquarks are discussed using the general, SU(3)_{C} x SU(2)_{W} x U(1)_{Y} invariant, effective Lagrangian. The corresponding dijet backgrounds are examined in the interested invariant mass regions. The attainable mass limits and couplings are obtained for the diquarks that can be produced in hadron collisions and in resolved photon processes. It is shown that hadron collider with center of mass energy sqrt(s)=14 TeV will be able to discover scalar and vector diquarks with masses up to m_{DQ}=9 TeV for quark-diquark-quark coupling alpha_{DQ}=0.1. Relatively, lighter diquarks can be probed at ep and e+e- collisions in more clear environment.Comment: 12 pages, 12 figures, 6 table

Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors

Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication. The aim of this study was to evaluate acute Brucella infections in mice receiving anti-TNFα drug treatment. Methodology: Anti-TNFα drugs were injected in mice on the first and fifth days of the study, after which the mice were infected with B. melitensis M16 strain. Mice were sacrificed on the fourteenth day after infection. Bacterial loads in the liver and spleen were defined, and histopathological changes were evaluated. Results: Neither the liver nor the spleen showed an increased bacterial load in all anti-TNFα drug groups when compared to a non-treated, infected group. The most significant histopathological findings were neutrophil infiltrations in the red pulp of the spleen and apoptotic cells with hepatocellular pleomorphism in the liver. There was no significant difference among the groups in terms of previously reported histopathological findings, such as extramedullary hematopoiesis and granuloma formation. Conclusions: There were no differences in hepatic and splenic bacterial load and granuloma formation, which indicate worsening of the acute Brucella infection in mice; in other words, anti-TNFα treatment did not exacerbate the acute Brucella spp. infection in mice. © 2015 Kutlu et al

Early phases of different types of isolated neutron star

Two Galactic isolated strong X-ray pulsars seem to be in the densest environments compared to other types of Galactic pulsar. X-ray pulsar J1846-0258 can be in an early phase of anomalous X-ray pulsars and soft gamma repeaters if its average braking index is ~1.8-2.0. X-ray pulsar J1811-1925 must have a very large average braking index (n~11) if this pulsar was formed by SN 386AD. This X-ray pulsar can be in an early phase of evolution of the radio pulsars located in the region P~50-150 ms and \.{P}~10$^{-14}-10^{-16}$ s/s of the P-\.{P} diagram. X-ray/radio pulsar J0540-69 seems to be evolving in the direction to the dim isolated thermal neutron star region on the P-\.{P} diagram. Possible progenitors of different types of neutron star are also discussed.Comment: to appear in the International Journal of Modern Physics

A simple way to reduce heat stress in laying hens as judged by egg laying, body weight gain and biochemical parameters

This study was designed to test the effects of feed withdrawal and darkening on the performance, triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), and some blood serum metabolite and mineral concentrations of laying hens reared at high ambient temperatures ranging from 25 to 35 °C. Ninety, 16-week-old hens (Ross Brown) were divided into 3 groups, 30 hens each. The first group was used as control. Hens in the second group (feed withdrawal) were subjected to feed removal from 14:00 to 18:00, and hens in the third group (darkening) were subjected to light restriction from 14:00 to 18:00 using black curtains. Liveweight, feed intake, and egg production were higher (P < 0.01) in the feed withdrawal and darkening groups, particularly in the darkening group, than in the control. Water intake was higher in the control group compared with the feed withdrawal and darkening groups (P < 0.01). T3, T4, and TSH concentrations in the serum were higher (P < 0.01), whereas ACTH serum concentration was lower (P < 0.01) in the feed withdrawal and darkening groups compared with the control. The haematocrit was higher in the feed withdrawal and darkening groups compared with the control (P < 0.01). Darkening and feed withdrawal treatments increased serum glucose, urea-N, uric acid, albumin, triglyceride, cholesterol, Ca, P, Na, and K concentrations, also the activities of amylase and alkaline phosphatase, but did not influence the activities of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). The present study found that feed withdrawal and darkening, particularly darkening, at high temperatures during the summer months offer a good management practice to reduce heat stress related depression in feed intake and egg production in laying hens

Ergenlerde öznel iyi oluş ve zaman tutumu: Benlik saygısı ve iyimserliğin aracı rolü

The aim of this research is to examine the mediatory role of self-esteem and optimism in the relationship between adolescents' subjective well-being and their time attitudes. A total of 529 students attending the 9th-12th grades of 13 high schools in Burdur and Denizli participated in the study. 320 of these students are female (60.5%), and 209 of them are male (39.5%), and their ages range between 15 and 18 (M=15.9; SD=.91). In the study, as data collection tools, Adolescent Time Attitude Inventory, Adolescent Subjective Well-Being Scale, Life Orientation Test and Coopersmith Self-Esteem Inventory Short Form were employed. According to the results obtained from the study, the attitude of adolescents is directly and significantly related to their subjective well-being, but this relationship significantly reduces in adolescents with high level of self-esteem and optimism

Optimization of F2 layer parameters using IRI-Plas and IONOLAB-TEC

In this study, the relation of the maximum ionization height (HmF2) and the critical frequency (FoF2) of F2 layer is examined within their parametric range through the International Reference Ionosphere extended towards the plasmasphere (IRI-Plas) model and the IONOLAB-TEC. HmF2 and FoF2 are optimized using an iterational loop through Non-Linear Least Squares method. HmF2 and FoF2 are obtained for various locations including Turkey for the same quiet day. Results are compared with ionosonde data where available. This study enables the modification and update of empirical and deterministic IRI Model to include instantaneous variability of the ionosphere. © 2011 IEEE

Occurrence of anthrax in Kars district, Turkey.

The aims of the study were to determine the prevalence of anthrax by bacteriologic methods in cattle and sheep between January 2000 and September 2001 and to determine the distribution of this zoonotic disease in humans in Kars district, Turkey. Bacillus anthracis was isolated and identified in 34 out of 38 (91%) cattle and 11 out of 17 (64%) sheep samples obtained from organs suspected of anthrax. The records of the Governmental Health Branch showed that 89 cases of cutaneous anthrax were diagnosed in humans during the study periods in the same district

Possible activation of the immune system by chronic peripheral nesfatin-1 application at the acute phase of ischemia/reperfusion injury

Objective: Organ transplantation is one of the clinical scenarios involving ischemia and reperfusion process. Ischemia/reperfusion is the pivotal mechanism of organ injury during transplantation. Thus, ischemia/reperfusion (I/R) injury is a biphasic phenomenon that can damage the graft by inflammatory responses. The hypothalamic-pituitary-adrenal (HPA) axis is the main hormonal system that is activated under the influence of stress. Normal HPA axis activity leading to the release of glucocorticoids is essential for homeostasis and survival during stress. Cortisol, a key controller of stress response, is released by the HPA axis. The disrupted release of cortisol in response to inflammation has been shown in animal models. Nesfatin-1 is a peptide involved in the regulation of homeostasis and has anti-inflammatory as well as anti-ischemic properties. Therefore, we aimed to identify the effect of chronic peripheral nesfatin-1 application on the plasma level of cortisol in a rat model of intestinal I/R-based stress. Materials and Methods: Two-month-old 28 Wistar Albino male rats that weighed an average of 200–250 g were used and were randomly divided into the following four experimental groups (n=7): laparotomy, I/R, nesfatin-1+laparotomy, nesfatin-1+I/R. Blood samples were collected in tubes with EDTA. Plasma cortisol levels were analyzed by rat enzyme-linked immunosorbent assay (ELISA) kits. Results: Statistically significant decrease was found in the plasma level of cortisol in nesfatin-1+I/R group compared with I/R group (p=0.026) Conclusion: Nesfatin-1 application can inhibit anti-inflammatory responses under the early phase of intestinal I/R and support immune reactions by reducing plasma cortisol level. This effect of nesfatin-1 may also increase the rejection of grafts during transplantation period. © 2015 by Erciyes University School of Medicine

Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience

Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey. Materials and Methods: Retrospective data of 40 patients with refractory ITP who were treated with eltrombopag in the Aegean region were examined and evaluated. Results: The total rate of response was 87%, and the median duration of response defined as the number of the platelets being over 50x109/L was 19.5 (interquartile range: 5-60) days. In one patient, venous sinus thrombosis was observed with no other additional risk factors due to or related to thrombosis. Another patient with complete response and irregular follow-up for 12 months was lost due to sudden death as the result of probable acute myocardial infarction. Conclusion: Although the responses to eltrombopag were satisfactory, patients need to be monitored closely for overshooting platelet counts as well as thromboembolic events. © 2015 Turkish Society of Hematology. All rights reserved