QSO 0130-4021: A third QSO showing a low Deuterium to Hydrogen Abundance Ratio

We have discovered a third quasar absorption system which is consistent with a low deuterium to hydrogen abundance ratio, D/H = 3.4 times 10^-5. The z ~ 2.8 partial Lyman limit system towards QSO 0130-4021 provides the strongest evidence to date against large D/H ratios because the H I absorption, which consists of a single high column density component with unsaturated high order Lyman series lines, is readily modeled -- a task which is more complex in other D/H systems. We have obtained twenty-two hours of spectra from the HIRES spectrograph on the W.M. Keck telescope, which allow a detailed description of the Hydrogen. We see excess absorption on the blue wing of the H I Lyman alpha line, near the expected position of Deuterium. However, we find that Deuterium cannot explain all of the excess absorption, and hence there must be contamination by additional absorption, probably H I. This extra H I can account for most or all of the absorption at the D position, and hence D/H = 0 is allowed. We find an upper limit of D/H < 6.7 times 10^-5 in this system, consistent with the value of D/H ~ 3.4 times 10^-5 deduced towards QSO 1009+2956 and QSO 1937-1009 by Burles and Tytler (1998a, 1998b). This absorption system shows only weak metal line absorption, and we estimate [Si/H] < -2.6 -- indicating that the D/H ratio of the system is likely primordial. All four of the known high redshift absorption line systems simple enough to provide useful limits on D are consistent with D/H = 3.4 +/- 0.25 times 10^-5. Conversely, this QSO provides the third case which is inconsistent with much larger values.Comment: 18 pages, 5 figures, submitted to Ap

Cosmological parameters sigma_8, the baryon density, and the UV background intensity from a calibrated measurement of H I Lyman-alpha absorption at z = 1.9

We identify a concordant model for the intergalactic medium (IGM) at redshift z=1.9 that uses popular values for cosmological and astrophysical parameters and accounts for all baryons with an uncertainty of 6%. We have measured the amount of absorption, DA, in the Ly-alpha forest at redshift 1.9 in spectra of 77 QSO from the Kast spectrograph. We calibrated the continuum fits with realistic artificial spectra, and we found that averaged over all 77 QSOs the mean continuum level is within 1-2% of the correct value. Absorption from all lines in the Ly-alpha forest at z=1.9 removes DA=15.1 +/- 0.7% of the flux between 1070 and 1170 (rest) Angstroms. This is the first measurement using many QSOs at this z, and the first calibrated measurement at any redshift. Metal lines absorb 2.3 +/- 0.5%, and LLS absorb 1.0 +/- 0.4% leaving 11.8 +/- 1.0% from the lower density bulk of the IGM. Averaging over Delta z=0.1 or 154 Mpc, the dispersion is 6.1 +/- 0.3% including LLS and metal lines, or 3.9 (+0.5, -0.7)% for the lower density IGM alone, consistent with the usual description of large scale structure. LLS and metal lines are major contributors to the variation in the mean flux, and they make the flux field significantly non-Gaussian. We find that a hydrodynamic simulation on a 1024 cubed grid in a 75.7 Mpc box reproduces the observed DA from the low density IGM with parameters values H_o=71 km/s/Mpc, Omega_Lambda=0.73, Omega_m=0.27, Omega_b=0.044, sigma_8=0.9 and a UV background that has an ionization rate that is 1.08 +/- 0.08 times the prediction by Madau, Haardt & Rees (1999).Comment: Submitted to Ap

The UCSD HIRES/KeckI Damped Lya Abundance Database III. An Empirical Study of Photoionization in the Damped Lya System Toward GB1759+7539

We investigate the ionization state of the damped Lya system at z=2.62 toward GB1759+7539 through an analysis of ionic ratios sensitive to photoionization: ArI/SII, FeIII/FeII, NII/NI, AlIII/AlII. Approximately half of the metals arise in a mostly neutral velocity component with HI/H > 0.9, based on FeIII/FeII < 0.013. In contrast, the remaining half exhibits FeIII/FeII~0.3 indicative of a partially ionized medium with HI/H~0.5. These conclusions are supported by the observed NII/NI, AlIII/AlII, and ArI/SII ratios. We assess ionization corrections for the observed column densities through photoionization models derived from the CLOUDY software package. In the neutral gas, the ionization corrections are negligible except for ArI. However for the partially ionized gas, element abundance ratios differ from the ionic ratios by 0.1-0.3 dex for (SiII, SII, NiII, AlII)/FeII ratios and more for (NI, ArI)/FeII. Independent of the shape of the photoionizing spectrum and assumptions on the number of ionization phases, these ionization corrections have minimal impact (<0.1dex) on the total metallicity inferred for this damped Lya system. Measurements on the relative elemental abundances of the partially ionized gas, however, have a greater than ~0.15 dex uncertainty which hides the effects of nucleosynthesis and dust depletion. We caution the reader that this damped system is unusual for a number of reasons (e.g. a very low ArI/SII ratio) and we believe its ionization properties are special but not unique. Nevertheless, it clearly shows the value of examining photoionization diagnostics like FeIII/FeII in a larger sample of systems.Comment: 19 pages with 11 b&w figures. Visit the DLA database at http://kingpin.ucsd.edu/~hiresdla for more. Accepted to the Astrophysical Journal, Feb 5 200

The Deuterium to Hydrogen Abundance Ratio Towards a Fourth QSO: HS0105+1619

We report the measurement of the primordial D/H abundance ratio towards QSO \object. The column density of the hydrogen in the $z \simeq 2.536$ Lyman limit system is high, \lnhi $= 19.422 \pm 0.009$ \cmm, allowing for the deuterium to be seen in 5 Lyman series transitions. The measured value of the D/H ratio towards QSO \object is found to be D/H$= 2.54 \pm 0.23 \times 10^{-5}$. The metallicity of the system showing D/H is found to be $\simeq 0.01$ solar, indicating that the measured D/H is the primordial D/H within the measurement errors. The gas which shows D/H is neutral, unlike previous D/H systems which were more highly ionized. Thus, the determination of the D/H ratio becomes more secure since we are measuring it in different astrophysical environments, but the error is larger because we now see more dispersion between measurements. Combined with prior measurements of D/H, the best D/H ratio is now D/H$= 3.0 \pm 0.4 \times 10^{-5}$, which is 10% lower than the previous value. The new values for the baryon to photon ratio, and baryonic matter density derived from D/H are $\eta = 5.6 \pm 0.5 \times 10^{-10}$ and \ob $=0.0205 \pm 0.0018$ respectively.Comment: Minor text and reference changes. To appear in the May 10, 2001 issue of the Astrophysical Journa

New HST spectra indicate the QSO PG1718+4807 will not give the primordial deuterium abundance

The z ~ 0.701 absorption system towards the QSO PG1718+4807 is the only example of a QSO absorption system which might have a deuterium/hydrogen ratio approximately ten times the value found towards other QSOs. We have obtained new STIS spectra from the Hubble Space Telescope of the Lyman alpha and Lyman limit regions of the system. These spectra give the redshift and velocity dispersion of the neutral hydrogen which produces most of the observed absorption. The Lyman alpha line is too narrow to account for all of the observed absorption. It was previously known that extra absorption is needed on the blue side of the main H I near to the expected position of deuterium. The current data suggests with a 98% confidence level that the extra absorption is not deuterium. Some uncertainty persists because we have a low signal to noise ratio and the extra absorption - be it deuterium or hydrogen - is heavily blended with the Lyman alpha absorption from the main hydrogen component.Comment: 18 pages, 7 figures, Submitted to Ap

Access to Artemisinin-Based Anti-Malarial Treatment and its Related Factors in Rural Tanzania.

Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends on how effective the use of ACT is within the routine health system. The INESS platform evaluated effective coverage of ACT in several African countries. Timely access within 24 hours to an authorized ACT outlet is one of the determinants of effective coverage and was assessed for artemether-lumefantrine (Alu), in two district health systems in rural Tanzania. From October 2009 to June 2011we conducted continuous rolling household surveys in the Kilombero-Ulanga and the Rufiji Health and Demographic Surveillance Sites (HDSS). Surveys were linked to the routine HDSS update rounds. Members of randomly pre-selected households that had experienced a fever episode in the previous two weeks were eligible for a structured interview. Data on individual treatment seeking, access to treatment, timing, source of treatment and household costs per episode were collected. Data are presented on timely access from a total of 2,112 interviews in relation to demographics, seasonality, and socio economic status. In Kilombero-Ulanga, 41.8% (CI: 36.6-45.1) and in Rufiji 36.8% (33.7-40.1) of fever cases had access to an authorized ACT provider within 24 hours of fever onset. In neither of the HDSS site was age, sex, socio-economic status or seasonality of malaria found to be significantly correlated with timely access. Timely access to authorized ACT providers is below 50% despite interventions intended to improve access such as social marketing and accreditation of private dispensing outlets. To improve prompt diagnosis and treatment, access remains a major bottle neck and new more innovative interventions are needed to raise effective coverage of malaria treatment in Tanzania

Change in Composition of the Anopheles Gambiae Complex and its Possible Implications for the Transmission of Malaria and Lymphatic Filariasis in North-Eastern Tanzania.

A dramatic decline in the incidence of malaria due to Plasmodium falciparum infection in coastal East Africa has recently been reported to be paralleled (or even preceded) by an equally dramatic decline in malaria vector density, despite absence of organized vector control. As part of investigations into possible causes for the change in vector population density, the present study analysed the Anopheles gambiae s.l. sibling species composition in north-eastern Tanzania. The study was in two parts. The first compared current species complex composition in freshly caught An. gambiae s.l. complex from three villages to the composition reported from previous studies carried out 2-4 decades ago in the same villages. The second took advantage of a sample of archived dried An. gambiae s.l. complex specimens collected regularly from a fourth study village since 2005. Both fresh and archived dried specimens were identified to sibling species of the An. gambiae s.l. complex by PCR. The same specimens were moreover examined for Plasmodium falciparum and Wuchereria bancrofti infection by PCR. As in earlier studies, An. gambiae s.s., Anopheles merus and Anopheles arabiensis were identified as sibling species found in the area. However, both study parts indicated a marked change in sibling species composition over time. From being by far the most abundant in the past An. gambiae s.s. was now the most rare, whereas An. arabiensis had changed from being the most rare to the most common. P. falciparum infection was rarely detected in the examined specimens (and only in An. arabiensis) whereas W. bancrofti infection was prevalent and detected in all three sibling species. The study indicates that a major shift in An. gambiae s.l. sibling species composition has taken place in the study area in recent years. Combined with the earlier reported decline in overall malaria vector density, the study suggests that this decline has been most marked for An. gambiae s.s., and least for An. arabiensis, leading to current predominance of the latter. Due to differences in biology and vectorial capacity of the An. gambiae s.l. complex the change in sibling species composition will have important implications for the epidemiology and control of malaria and lymphatic filariasis in the study area

A common missense variant of <i>LILRB₅</i> is associated with statin intolerance and myalgia

Aims A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. We examined the association of this variant with statin intolerance ascertained from electronic medical records in the GoDARTS study. Methods and results In the GoDARTS cohort, the LILRB5 Asp247 variant was associated with statin intolerance (SI) phenotypes; one defined as having raised CK and being non-adherent to therapy [odds ratio (OR) 1.81; 95% confidence interval (CI): 1.34–2.45] and the other as being intolerant to the lowest approved dose of a statin before being switched to two or more other statins (OR 1.36; 95% CI: 1.07–1.73). Those homozygous for Asp247 had increased odds of developing both definitions of intolerance. Importantly the second definition did not rely on CK elevations. These results were replicated in adjudicated cases of statin-induced myopathy in the PREDICTION-ADR consortium (OR1.48; 95% CI: 1.05–2.10) and for the development of myalgia in the JUPITER randomized clinical trial of rosuvastatin (OR1.35, 95% CI: 1.10–1.68). A meta-analysis across the studies showed a consistent association between Asp247Gly and outcomes associated with SI (OR1.34; 95% CI: 1.16–1.54). Conclusion This study presents a novel immunogenetic factor associated with statin intolerance, an important risk factor for cardiovascular outcomes. The results suggest that true statin-induced myalgia and non-specific myalgia are distinct, with a potential role for the immune system in their development. We identify a genetic group that is more likely to be intolerant to their statins