Analisis Implementasi Promotional Mix dalam Meningkatkan Volume Penjualan Kendaraan Bermotor (Kasus pada Dealer Motor Yamaha Pt.dasatama Cemerlang Motorindo Dumai)

Promotional mix is a combination of the best strategy of the variables of advertising , sales promotion , publicity , personal selling all of which are planned to achieve sales program . The sales volume is the end result achieved by the company from the sales generated by the company. PT . Dasatama Cemerlang Motorindo Dumai is a company engaged in the sale , service and spare parts of motorcycles yamaha . In the normal course of business the last few years the company was not able to achieve sales targets and sales volumes decreased . Promotion strategies used are promotional mix such as advertising , sales promotion , publicity , personal selling . The results of this study indicate that the analysis of the implementation of promotional mix effect on the increase in sales volume . Judging from the responses of respondents who chose a variable advertising compared to many other variables that will further optimize the increase in volume of sales at PT . Dasatama Cemerlang Motorindo Dumai

Perancangan Buku Anak Cerita Topeng Dan Pesta Roh Suku Asmat Melalui Ilustrasi Seni Kertas

Ilustrasi eksperimental merupakan sebuah pendekatan ilustrasi menggunakan media non-konvensional, salah satunya seni kertas. Di Indonesia masihjarang ditemui buku anak yang menggunakan pendekatan tersebut. Dengan kemungkinan tersebut, didesain sebuah buku anak artistik yangmengangkat cerita rakyat bersumber dari Suku Asmat dengan memperkenalkan seni kertas untuk menarik perhatian anak-anak. Buku anak berjudul“Pesta Topeng” didesain berdasarkan analisis antara teori desain buku anak dan data literature mengenai kertas seni dan Suku Asmat. Buku inidirancang berdasarkan aspek-aspek cerita, ilustrasi dan storytelling. Perancangan ini dapat di terapkan dan dikembangkan pada buku anak yangmengangkat cerita rakyat lainnya

Fisheries and biodiversity along Mediterranean Sea: Italian and Egyptian coast overview

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Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles

There are very few drug delivery systems that target key organs via the oral route, as oral delivery advances normally address gastrointestinal drug dissolution, permeation, and stability. Here we introduce a nanomedicine in which nanoparticles, while also protecting the drug from gastric degradation, are taken up by the gastrointestinal epithelia and transported to the lung, liver, and spleen, thus selectively enhancing drug bioavailability in these target organs and diminishing kidney exposure (relevant to nephrotoxic drugs). Our work demonstrates, for the first time, that oral particle uptake and translocation to specific organs may be used to achieve a beneficial therapeutic response. We have illustrated this using amphotericin B, a nephrotoxic drug encapsulated within <i>N</i>-palmitoyl-<i>N</i>-methyl-<i>N</i>,<i>N</i>-dimethyl-<i>N</i>,<i>N</i>,<i>N</i>-trimethyl-6-<i>O</i>-glycol chitosan (GCPQ) nanoparticles, and have evidenced our approach in three separate disease states (visceral leishmaniasis, candidiasis, and aspergillosis) using industry standard models of the disease in small animals. The oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral liposomal AmB (AmBisome). Our work thus paves the way for others to use nanoparticles to achieve a specific targeted delivery of drug to key organs via the oral route. This is especially important for drugs with a narrow therapeutic index

O PRAD NO CONTEXTO DA RECUPERAÇÃO DAS BACIAS HIDROGRÁFICAS DO ESTADO DE SÃO PAULO

o texto apresentado contempla a necessidade de recuperação de áreas degradadas pela atividade minerária (especificamente pela extração de areia para construção civil) e sua relação com a recomposição do ambiente ribeirinho no Estado de São Paulo. Em linhas gerais são fornecidos no trabalho todos os aspectos envolvidos na recuperação dessas áreas, nos âmbitos federal, estadual e municipal. No decorrer do texto, são abordados alguns conceitos sobre a recomposição do ambiente ribeirinho já amplamente discutidos na literatura. Além dessas informações, o trabalho também fornece uma análise da distribuição dosPlanos de Recuepração de Áreazs Degradadas (PRAD's) protocolados na SMA de outubro de 1989 a dezembro de 1991 , nas diferentes regiões do estado de São Paulo, identificando a região leste do estado como a de maior ocorrência desses empreendimentos. São relacionados os principais fatores que contribuem para esta concentração, quais sejam: geológicos, geomorfológicos e econômicos. É ainda apresentada a atuação do Departamento de Avaliaçãode ImpactoAmbiental- DAIAnaanálisedos PRAD's, salientando anecessidade de um enfoque regional para a avaliação desses documentos, visando sua concordância com as leis ambientais em vigor e, sobretudo, com os programas ambientais de cada bacia hidrográfica do estado de São Paulo

A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: a randomized controlled trial (HELFIMED)

We investigated whether a Mediterranean-style diet (MedDiet) supplemented with fish oil can improve mental health in adults suffering depression.Adults with self-reported depression were randomized to receive fortnightly food hampers and MedDiet cooking workshops for 3 months and fish oil supplements for 6 months, or attend social groups fortnightly for 3 months. Assessments at baseline, 3 and 6 months included mental health, quality of life (QoL) and dietary questionnaires, and blood samples for erythrocyte fatty acid analysis.n = 152 eligible adults aged 18-65 were recruited (n = 95 completed 3-month and n = 85 completed 6-month assessments). At 3 months, the MedDiet group had a higher MedDiet score (t = 3.95, P < 0.01), consumed more vegetables (t = 3.95, P < 0.01), fruit (t = 2.10, P = 0.04), nuts (t = 2.29, P = 0.02), legumes (t = 2.41, P = 0.02) wholegrains (t = 2.63, P = 0.01), and vegetable diversity (t = 3.27, P < 0.01); less unhealthy snacks (t = -2.10, P = 0.04) and red meat/chicken (t = -2.13, P = 0.04). The MedDiet group had greater reduction in depression (t = -2.24, P = 0.03) and improved mental health QoL scores (t = 2.10, P = 0.04) at 3 months. Improved diet and mental health were sustained at 6 months. Reduced depression was correlated with an increased MedDiet score (r = -0.298, P = 0.01), nuts (r = -0.264, P = 0.01), and vegetable diversity (r = -0.303, P = 0.01). Other mental health improvements had similar correlations, most notably for increased vegetable diversity and legumes. There were some correlations between increased omega-3, decreased omega-6 and improved mental health.This is one of the first randomized controlled trials to show that healthy dietary changes are achievable and, supplemented with fish oil, can improve mental health in people with depression.Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Sarah Blunden, Barbara Meyer, Leonie Segal, Bernhard T. Baune and Kerin O’De