314 research outputs found
On geometry of hypersurfaces of a pseudoconformal space of Lorentzian signature
There are three types of hypersurfaces in a pseudoconformal space C^n_1 of
Lorentzian signature: spacelike, timelike, and lightlike. These three types of
hypersurfaces are considered in parallel. Spacelike hypersurfaces are endowed
with a proper conformal structure, and timelike hypersurfaces are endowed with
a conformal structure of Lorentzian type. Geometry of these two types of
hypersurfaces can be studied in a manner that is similar to that for
hypersurfaces of a proper conformal space. Lightlike hypersurfaces are endowed
with a degenerate conformal structure. This is the reason that their
investigation has special features. It is proved that under the Darboux mapping
such hypersurfaces are transferred into tangentially degenerate
(n-1)-dimensional submanifolds of rank n-2 located on the Darboux hyperquadric.
The isotropic congruences of the space C^n_1 that are closely connected with
lightlike hypersurfaces and their Darboux mapping are also considered.Comment: LaTeX, 21 page
Identifying patients' support needs following critical illness:A scoping review of the qualitative literature
BACKGROUND: Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors' transition from the intensive care unit to home, their support needs develop and change. METHODS: In this scoping review, we categorised patients' support needs using House's Social Support Needs framework (informational, emotional, instrumental, appraisal) and mapped these against the Timing it Right framework reflecting the patient's transition from intensive care (event/diagnosis) to ward (stabilisation/preparation) and discharge home (implementation/adaptation). We searched electronic databases from 2000 to 2017 for qualitative research studies reporting adult critical care survivors' experiences of care. Two reviewers independently screened, extracted and coded data. Data were analysed using a thematic framework approach. RESULTS: From 3035 references, we included 32 studies involving 702 patients. Studies were conducted in UK and Europe (nâ=â17, 53%), Canada and the USA (nâ=â6, 19%), Australasia (nâ=â6, 19%), Hong Kong (nâ=â1, 3%), Jordan (nâ=â1, 3%) and multi-country (nâ=â1, 3%). Across the recovery trajectory, informational, emotional, instrumental, appraisal and spiritual support needs were evident, and the nature and intensity of need differed when mapped against the Timing it Right framework. Informational needs changed from needing basic facts about admission, to detail about progress and treatments and coping with long-term sequelae. The nature of emotional needs changed from needing to cope with confusion, anxiety and comfort, to a need for security and family presence, coping with flashbacks, and needing counselling and community support. Early instrumental needs ranged from managing sleep, fatigue, pain and needing nursing care and transitioned to needing physical and cognitive ability support, strength training and personal hygiene; and at home, regaining independence, strength and return to work. Appraisal needs related to obtaining feedback on progress, and after discharge, needing reassurance from others who had been through the ICU experience. CONCLUSIONS: This review is the first to identify the change in social support needs among intensive care survivors as they transition from intensive care to the home environment. An understanding of needs at different transition periods would help inform health service provision and support for survivors
The EBV-encoded oncoprotein, LMP1, induces an epithelial-to-mesenchymal transition (EMT) via Its CTAR1 domain through integrin-mediated ERK-MAPK signalling
The Epsteinâ»Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) oncogene can induce profound effects on epithelial growth and differentiation including many of the features of the epithelial-to-mesenchymal transition (EMT). To better characterise these effects, we used the well-defined Madin Darby Canine Kidney (MDCK) epithelial cell model and found that LMP1 expression in these cells induces EMT as defined by characteristic morphological changes accompanied by loss of E-cadherin, desmosomal cadherin and tight junction protein expression. The induction of the EMT phenotype required a functional CTAR1 domain of LMP1 and studies using pharmacological inhibitors revealed contributions from signalling pathways commonly induced by integrinâ»ligand interactions: extracellular signal-regulated kinases/mitogen-activated protein kinases (ERK-MAPK), PI3-Kinase and tyrosine kinases, but not transforming growth factor beta (TGFβ). More detailed analysis implicated the CTAR1-mediated induction of Slug and Twist in LMP1-induced EMT. A key role for β1 integrin signalling in LMP1-mediated ERK-MAPK and focal adhesion kianse (FAK) phosphorylation was observed, and β1 integrin activation was found to enhance LMP1-induced cell viability and survival. These findings support an important role for LMP1 in disease pathogenesis through transcriptional reprogramming that enhances tumour cell survival and leads to a more invasive, metastatic phenotype
Existence of the Abrikosov vortex state in two-dimensional type-II superconductors without pinning
Theory alternative to the vortex lattice melting theories is advertised. The
vortex lattice melting theories are science fiction cond-mat/9811051 because
the Abrikosov state is not the vortex lattice with crystalline long-range
order. Since the fluctuation correction to the Abrikosov solution is infinite
in the thermodynamic limit (K.Maki and H.Takayama, 1972) any fluctuation theory
of the mixed state should consider a superconductor with finite sizes. Such
nonperturbative theory for the easiest case of two-dimensional superconductor
in the lowest Landau level approximation is presented in this work. The
thermodynamic averages of the spatial average order parameter and of the
Abrikosov parameter are calculated. It is shown that the position
H_{c4} of the transition into the Abrikosov state (i.e. in the mixed state with
long-range phase coherence) depends strongly on sizes of two-dimensional
superconductor. Fluctuations eliminate the Abrikosov vortex state in a wide
region of the mixed state of thin films with real sizes and without pinning
disorders, i.e. H_{c4} << H_{c2}. The latter has experimental corroboration in
Phys.Rev.Lett. 75, 2586 (1995).Comment: 4 pages, 0 figure
European Multidisciplinary and Water-Column Observatory - European Research Infrastructure Consortium (EMSO ERIC): challenges and opportunities for strategic European marine sciences
EMSO (European Multidisciplinary Seafloor and water-column Observatory,
www.emso-eu.org) is a largeâscale European Research Infrastructure I. It
is a distributed infrastructure of strategically placed, deepâsea seafloor and water
column observatory nodes with the essential scientific objective of realâtime, longterm
observation of environmental processes related to the interaction between the
geosphere, biosphere, and hydrosphere. The geographic locations of the EMSO observatory
nodes represent key sites in European waters, from the Arctic, through the
Atlantic and Mediterranean, to the Black Sea (Figure 1), as defined through previous
studies performed in FP6 and FP7 EC projects such as ESONETâCA, ESONETâNoE,
EMSO-PP (Person et al., 2015)Peer Reviewe
Veterinary drug therapies used for undesirable behaviours in UK dogs under primary veterinary care
Undesirable behaviours (UBs) in dogs are common and important issues with serious potential welfare consequences for both the dogs and their owners. This study aimed to investigate the usage of drug therapy for UBs in dogs and assess demographic risk factors for drug-prescribed UBs within the dog population under primary-care veterinary care in the UK in 2013. Dogs receiving drug therapy for UB were identified through the retrospective analysis of anonymised electronic patient records in VetCompassâą. Risk factor analysis used multivariable logistic regression modelling. The study population comprised 103,597 dogs under veterinary care in the UK during 2013. There were 413 drug-prescribed UBs recorded among 404 dogs. The prevalence of dogs with at least one UB event treated with a drug in 2013 was 0.4%. Multivariable modelling identified 3 breeds with increased odds of drug-prescribed UB compared with crossbred dogs: Toy Poodle (OR 2.75), Tibetan Terrier (OR 2.68) and Shih-tzu (OR 1.95). Increasing age was associated with increased odds of drug-prescribed UB, with dogs â„ 12 years showing 3.1 times the odds compared with dogs < 3 years. Neutered males (OR 1.82) and entire males (OR 1.50) had increased odds compared with entire females. The relatively low prevalence of dogs with at least one UB event that was treated with a drug in 2013 could suggest that opportunities for useful psychopharmaceutical intervention in UBs may be being missed in first opinion veterinary practice. While bodyweight was not a significant factor, the 3 individual breeds at higher odds of an UB treated with a behaviour modifying drug all have a relatively low average bodyweight. The current results also support previous research of a male predisposition to UBs and it is possible that this higher risk resulted in the increased likelihood of being prescribed a behaviour modifying drug, regardless of neuter status
Complementary approaches to understanding the plant circadian clock
Circadian clocks are oscillatory genetic networks that help organisms adapt
to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri
is the simplest plant clock discovered so far. Its many advantages as an
experimental system facilitate the testing of computational predictions.
We present a model of the Ostreococcus clock in the stochastic process
algebra Bio-PEPA and exploit its mapping to different analysis techniques, such
as ordinary differential equations, stochastic simulation algorithms and
model-checking. The small number of molecules reported for this system tests
the limits of the continuous approximation underlying differential equations.
We investigate the difference between continuous-deterministic and
discrete-stochastic approaches. Stochastic simulation and model-checking allow
us to formulate new hypotheses on the system behaviour, such as the presence of
self-sustained oscillations in single cells under constant light conditions.
We investigate how to model the timing of dawn and dusk in the context of
model-checking, which we use to compute how the probability distributions of
key biochemical species change over time. These show that the relative
variation in expression level is smallest at the time of peak expression,
making peak time an optimal experimental phase marker. Building on these
analyses, we use approaches from evolutionary systems biology to investigate
how changes in the rate of mRNA degradation impacts the phase of a key protein
likely to affect fitness. We explore how robust this circadian clock is towards
such potential mutational changes in its underlying biochemistry. Our work
shows that multiple approaches lead to a more complete understanding of the
clock
Anthocyanins do not influence long-chain n-3 fatty acid status:Studies in cells, rodents and humans
Increased tissue status of the long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) is associated with cardiovascular and cognitive benefits. Limited epidemiological and animal data suggest that flavonoids, and specifically anthocyanins, may increase EPA and DHA levels, potentially by increasing their synthesis from the shorter-chain n-3 PUFA, α-linolenic acid. Using complimentary cell, rodent and human studies we investigated the impact of anthocyanins and anthocyanin-rich foods/extracts on plasma and tissue EPA and DHA levels and on the expression of fatty acid desaturase 2 (FADS2), which represents the rate limiting enzymes in EPA and DHA synthesis. In experiment 1, rats were fed a standard diet containing either palm oil or rapeseed oil supplemented with pure anthocyanins for 8 weeks. Retrospective fatty acid analysis was conducted on plasma samples collected from a human randomized controlled trial where participants consumed an elderberry extract for 12 weeks (experiment 2). HepG2 cells were cultured with α-linolenic acid with or without select anthocyanins and their in vivo metabolites for 24 h and 48 h (experiment 3). The fatty acid composition of the cell membranes, plasma and liver tissues were analyzed by gas chromatography. Anthocyanins and anthocyanin-rich food intake had no significant impact on EPA or DHA status or FADS2 gene expression in any model system. These data indicate little impact of dietary anthocyanins on n-3 PUFA distribution and suggest that the increasingly recognized benefits of anthocyanins are unlikely to be the result of a beneficial impact on tissue fatty acid status
Timelike surfaces of constant mean curvature 1 in anti-de Sitter 3-space
It is shown that timelike surfaces of constant mean curvature 1 in anti-de
Sitter 3-space can be constructed from a pair of Lorentz holomorphic and
Lorentz antiholomorphic null curves in PSL(2,R) via Bryant type representation
formulae. These formulae are used to investigate an explicit one-to-one
correspondence, the so-called Lawson correspondence, between timelike surfaces
of constant mean curvature 1 in anti-de Sitter 3-space and timelike minimal
surfaces in Minkowski 3-space. The hyperbolic Gauss map of timelike surfaces in
anti-de Sitter 3-space, which is a close analogue of the classical Gauss map is
considered. It is discussed that the hyperbolic Gauss map plays an important
role in the study of timelike surfaces of constant mean curvature 1 in anti-de
Sitter 3-space. In particular, the relationship between the Lorentz
holomorphicity of the hyperbolic Gauss map and timelike surfaces of constant
mean curvature 1 in anti-de Sitter 3-space is studied.Comment: 47 pages, 24 figures, references revised, Annals of Global Analysis
and Geometr
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
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