When shareholders and customers have distinct interests

A recent poll asked business leaders which party, Labour or the Conservatives, would be good for shareholders and which would be good for customers. Surprisingly, and contrary to the adage that companies maximise shareholder value by producing better value for their customers, the answers they gave were different. A Labour government was seen as better for customers, and the Conservatives for shareholders. Duncan O’Leary examines what’s going on

Britain’s politicians should take note: The ‘grey vote’ is not as grey as we think

A new report from Demos & Ipsos MORI finds that, contrary to popular belief, a large part of the support for pensioner spending comes from voters at the other end of the age spectrum, with those born between 1980 and 2000 three time as likely to choose pensions than unemployment benefits when asked to pick priorities. Duncan O’Leary and Bobby Duffy examine the implications of this and find an underlying principle: The desire for a reciprocal welfare system, which protects people when they need it and encourages the right behaviour in others

Integrity Testing of Pile Cover Using Distributed Fibre Optic Sensing.

The integrity of cast-in-place foundation piles is a major concern in geotechnical engineering. In this study, distributed fibre optic sensing (DFOS) cables, embedded in a pile during concreting, are used to measure the changes in concrete curing temperature profile to infer concrete cover thickness through modelling of heat transfer processes within the concrete and adjacent ground. A field trial was conducted at a high-rise building construction site in London during the construction of a 51 m long test pile. DFOS cables were attached to the reinforcement cage of the pile at four different axial directions to obtain distributed temperature change data along the pile. The monitoring data shows a clear development of concrete hydration temperature with time and the pattern of the change varies due to small changes in concrete cover. A one-dimensional axisymmetric heat transfer finite element (FE) model is used to estimate the pile geometry with depth by back analysing the DFOS data. The results show that the estimated pile diameter varies with depth in the range between 1.40 and 1.56 m for this instrumented pile. This average pile diameter profile compares well to that obtained with the standard Thermal Integrity Profiling (TIP) method. A parametric study is conducted to examine the sensitivity of concrete and soil thermal properties on estimating the pile geometry

Rubisco lysine acetylation occurs at very low stoichiometry in mature Arabidopsis leaves: implications for regulation of enzyme function

Multiple studies have shown ribulose-1,5-bisphosphate carboxylase/oxygenase (E.C. 4.1.1.39; Rubisco) to be subject to Lys-acetylation at various residues; however, opposing reports exist about the biological significance of these post-translational modifications. One aspect of the Lys-acetylation that has not been addressed in plants generally, or with Rubisco specifically, is the stoichiometry at which these Lys-acetylation events occur. As a method to ascertain which Lys-acetylation sites on Arabidopsis Rubisco might be of regulatory importance to its catalytic function in the Calvin-Benson cycle, we purified Rubisco from leaves in both the day and night-time and performed independent mass spectrometry based methods to determine the stoichiometry of Rubisco Lys-acetylation events. The results indicate that Rubisco is acetylated at most Lys residues, but each acetylation event occurs at very low stoichiometry. Furthermore, in vitro treatments that increased the extent of Lys-acetylation on purified Rubisco had no effect on Rubisco maximal activity. Therefore, we are unable to confirm that Lys-acetylation at low stoichiometries can be a regulatory mechanism controlling Rubisco maximal activity. The results highlight the need for further use of stoichiometry measurements when determining the biological significance of reversible PTMs like acetylation.This work was supported through funding by the Australian Research Council (ARC) to B.M.O. as a DECRA Fellow (DE150100130) and A.H.M. through the ARC Centre of Excellence in Plant Energy Biology (CE140100008)

Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1

Peer reviewedPublisher PD

Locus of control and its intergenerational implications forearly childhood skill formation

This paper builds upon Cunha’s (2015) subjective rationality model in which parents have a subjective belief about the impact of their investment on the early skill formation of their children. We propose that this subjective belief is determined in part by locus of control (LOC), i.e., the extent to which individuals believe that their actions can influence future outcomes. Consistent with the theory, we show that maternal LOC measured at the 12th week of gestation strongly predicts maternal attitudes towards parenting style, maternal time investments, as well as early and late cognitive outcomes. We also utilize the variation in inputs and outputs by maternal LOC to help improve the specification typically used in the estimation of skill production function parameters

Therapeutic emails

BACKGROUND: In this paper, we show how counselors and psychologists can use emails for online management of substance abusers, including the anatomy and content of emails that clinicians should send substance abusers. Some investigators have attempted to determine if providing mental health services online is an efficacious delivery of treatment. The question of efficacy is an empirical issue that cannot be settled unless we are explicitly clear about the content and nature of online treatment. We believe that it is not the communications via internet that matters, but the content of these communications. The purpose of this paper is to provide the content of our online counseling services so others can duplicate the work and investigate its efficacy. RESULTS: We have managed nearly 300 clients online for recovery from substance abuse. Treatment included individual counseling (motivational interviewing, cognitive-behavior therapy, relapse prevention assignments), participation in an electronic support group and the development of a recovery team. Our findings of success with these interventions are reported elsewhere. Our experience has led to development of a protocol of care that is described more fully in this paper. This protocol is based on stages of change and relapse prevention theories and follows a Motivational Interviewing method of counseling. CONCLUSION: The use of electronic media in providing mental health treatment remains controversial due to concerns about confidentiality, security and legal considerations. More research is needed to validate and generalize the use of online treatment for mental health problems. If researchers have to build on each others work, it is paramount that we share our protocols of care, as we have done in this paper