Dravet syndrome patient‐derived neurons suggest a novel epilepsy mechanism

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99647/1/ana23897.pd

Highlights From the Annual Meeting of the American Epilepsy Society 2022

With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia

Leptin Stimulation of COXIV is Impaired in Obese Skeletal Muscle Myotubes

The principle finding of this study is the further demonstration of the metabolic inflexibility of skeletal muscle myotubes developed from morbidly obese individuals. It was demonstrated that the acute exposure of cultured skeletal muscle myotubes derived from obese individuals to leptin failed to alter the expression of several key lipid oxidative and mitochondrial genes. Contrary to the obese derived myotubes, cells derived from lean and healthy controls demonstrated a capacity to increase the expression of several key genes. Further analysis is required to elucidate the mechanisms involved, with studies needed to examine leptin-receptor mediated events

Between physical and electronic spaces : The implications for organisations in the networked economy

With the rapid development of computing and telecommunications infrastructure, a new electronic space has emerged which coexists, and sometimes intertwines, with the physical space and place of our world. This has greatly increased the complexity and flexibility of the new space economy for organisations and individuals, and increasingly we have to live in 'two spaces'. Since the late 1980s researchers have successfully dismissed the misconception about the 'death of distance' in the information economy. However, the dissemination of this progress has been slow and fragmented. Utopian views about the 'end of geography' remain very influential in current business thinking and in research on information systems and organisational innovations. Numerous failed business applications of information systems have resulted from a lack of geographical considerations. This situation has been significantly exacerbated in the last few years by the rapid developments of the Internet and new applications based on it, such as e-commerce and e-business. Researchers have a duty not only to understand the new geography of the information economy, but also to inform the public about the key features of the 'two spaces' that all organisations and individuals have to live in. In this paper, some case studies and emerging business phenomena are used to illustrate the importance of introducing a geographical dimension into research on information systems and organisational innovations. Several new themes for further research are also highlighted