Omega-3 Fatty Acid Consumption and Food Sources Differ among Elderly Men Living in Coastal and Internal Regions of Saudi Arabia

Research suggests that omega-3 fatty acids (n-3 FAs) play an important role in reducing the risk of heart diseases. The objectives of the current study were to investigate the consumption and the food sources of n-3 FAs in two samples of elderly men living in different geographic locations (coastal and internal regions) of Saudi Arabia. Sixty men from each of the coastal and the internal regions provided a 24-hour recall and 2-day food record and a food frequency questionnaire. Food Processor Plus computer program software (ESHA Version 0.7; Salem, Oregon, 2002) was used to analyze the dietary intake. The intake of total n-3 FAs, alpha-lenolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were higher among the coastal region residents than among the internal residents (P \u3c 0.05). English walnuts, salmon, canola oil, malabar cavalla and king mackerel were the top five foods contributing to the n-3 FA intakes in the coastal region. The top five foods contributing to the n-3 FA intakes in the internal region were English walnuts, lamb, whole milk, baked beans and chicken. The food contributing the most to the intake of n-3 FAs in both regions were English walnuts. In conclusion, the food consumption pattern for food providing n-3 FAs differs by location and coastal residents consume more than twice as much n-3 FAs as internal residents. Nutrition education intervention among internal residents is needed for increasing the consumption of n-3 FAs

A Proposed IoT Architecture for Effective Energy Management in Smart Microgrids

yesThe current electricity grid suffers from numerous challenges due to the lack of an effective energy management strategy that is able to match the generated power to the load demand. This problem becomes more pronounced with microgrids, where the variability of the load is obvious and the generation is mostly coming from renewables, as it depends on the usage of distributed energy sources. Building a smart microgrid would be much more economically feasible than converting the large electricity grid into a smart grid, as it would require huge investments in replacing legacy equipment with smart equipment. In this paper, application of Internet of Things (IoT) technology in different parts of the microgrid is carried out to achieve an effective IoT architecture in addition to proposing the Internet-of-Asset (IoA) concept that will be able to convert any legacy asset into a smart IoT-ready one. This will allow the effective connection of all assets to a cloud-based IoT. The role of which is to perform computations and big data analysis on the collected data from across the smart microgrid to send effective energy management and control commands to different controllers. Then the IoT cloud will send control actions to solve microgrid's technical issues such as solving energy mismatch problem by setting prediction models, increasing power quality by the effective commitment of DERs and eliminating load shedding by turning off only unnecessary loads so consumers won't suffer from power outages. The benefits of using IoT on various parts within the microgrid are also addressed

Partitioning the environmental drivers of immunocompetence

By determining susceptibility to disease, environment-driven variation in immune responses can affect the health, productivity and fitness of vertebrates. Yet how the different components of the total environment control this immune variation is remarkably poorly understood. Here, through combining field observation, experimentation and modelling, we are able to quantitatively partition the key environmental drivers of constitutive immune allocation in a model wild vertebrate (three-spined stickleback, Gasterosteus aculeatus). We demonstrate that, in natural populations, thermal conditions and diet alone are sufficient (and necessary) to explain a dominant (seasonal) axis of variation in immune allocation. This dominant axis contributes to both infection resistance and tolerance and, in turn, to the vital rates of infectious agents and the progression of the disease they cause. Our results illuminate the environmental regulation of vertebrate immunity (given the evolutionary conservation of the molecular pathways involved) and they identify mechanisms through which immunocompetence and host-parasite dynamics might be impacted by changing environments. In particular, we predict a dominant sensitivity of immunocompetence and host-pathogen dynamics to host diet shifts

2D and 3D seismic simulation for fault modeling: exploratory revision from the Gullfaks field

2D and 3D seismic data have emerged as a key tool in the oil and gas industry to visualize and understand subsurface morphology and boundaries. In addition to providing excellent structural images, the dense sampling of 2D and 3D survey can sometimes make it possible to map reservoir quality and the distribution of hydrocarbon with well-marked limitations. Here we use 2D and 3D seismic data to map and interpret basic structures and fault lines to construct 2D and 3D base fault models of the Gullfaks field, while avoiding common pitfalls. This work also highlights important concepts and principles that allow selection, interpretation and simulation of particular areas containing hydrocarbon traps through the comparison of different maps such as time structure, amplitude and coherence. The field covers an area of approximately 50 km(2) entirely confined within block 34/10 in the Norwegian sector of the North Sea. The area of the seismic lines extends to 4875 m laterally and vertically up to 4.5 s. Based on all the selected horizons, constructed maps and dominant fault construction models (2D and 3D), we show the presence of a major fault that cuts five horizons of the area of interest. The structural features include antiform and a set of extensional faults with master, antithetic and synthetic faults with opposite sense of shear (dip direction and angle similar to 60A degrees). Ductile deformation at the bottom of seismic lines shows the fluctuation of amplitude of acoustic signals in seismic lines. Our results demonstrate uplift along the major fault during extension indicated by chaotic distortion at the bottom, which reveals a gas trap. In the Gullfaks field, termination of fault movement and subsequent deformation appears to have occurred for a long period of time. This illustrates the use of 2D and 3D visualization with horizon attributes that can conveniently provide massive amounts of data which elucidates the trapping mechanism of faults

Small Stem Total Hip Arthroplasty in Hypoplasia of the Femur

Total hip arthroplasty in hypoplastic femurs is technically difficult and the incidence of complications and aseptic loosening is relatively high. Cemented, uncemented, off-the-shelf, and custom-made stems all have been advocated in these cases. From 1978 to 1997, we performed 86 total hip arthroplasties in 77 patients with a hypoplastic femur using a cemented, off-the-shelf, small, curved, cobalt-chromium stem. We hypothesized results equaled those of the identical but larger-sized stems in normal-sized femora which were used as comparisons. Clinical and radiographic evaluations were performed. Minimum followup was 4.2 years (mean, 12 years; range, 4.2–20.3 years); mean Harris hip score was 88, and mean hip flexion was 104°. Six stems were revised: four because of aseptic loosening, one after a femoral fracture, and one because of malpositioning. Complications included one perforation and one fracture of the femur, one fracture, one nonunion of the greater trochanter, and one deep infection. Implant survivorship for all hips at 15 years with aseptic revision of the stem as the end point was 90% (confidence interval, 82–99) which equaled results of the larger stems. The small off-the-shelf cemented Weber stem has a high long-term survival and a low complication rate. Survival compares favorably with other small-sized total hip systems

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

<p>Abstract</p> <p>Background</p> <p><it>Asclepias curassavica </it>Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of β-sitosterol isolated from <it>A. curassavica </it>in colon cancer, using <it>in vitro </it>and <it>in vivo </it>models.</p> <p>Methods</p> <p>The active molecule was isolated, based upon bioassay guided fractionation, and identified as β-sitosterol on spectral evidence. The ability to induce apoptosis was determined by its <it>in vitro </it>antiradical activity, cytotoxic studies using human colon adenocarcinoma and normal monkey kidney cell lines, and the expression of β-catenin and proliferating cell nuclear antigen (PCNA) in human colon cancer cell lines (COLO 320 DM). The chemopreventive potential of β-sitosterol in colon carcinogenesis was assessed by injecting 1,2-dimethylhydrazine (DMH, 20 mg/kg b.w.) into male Wistar rats and supplementing this with β-sitosterol throughout the experimental period of 16 weeks at 5, 10, and 20 mg/kg b.w.</p> <p>Results</p> <p>β-sitosterol induced significant dose-dependent growth inhibition of COLO 320 DM cells (IC₅₀266.2 μM), induced apoptosis by scavenging reactive oxygen species, and suppressed the expression of β-catenin and PCNA antigens in human colon cancer cells. β-sitosterol supplementation reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner with no toxic effects.</p> <p>Conclusion</p> <p>We found doses of 10-20 mg/kg b.w. β-sitosterol to be effective for future <it>in vivo </it>studies. β-sitosterol had chemopreventive potential by virtue of its radical quenching ability <it>in vitro</it>, with minimal toxicity to normal cells. It also attenuated β-catenin and PCNA expression, making it a potential anticancer drug for colon carcinogenesis.</p

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection