76 research outputs found
The use of clinical study reports to enhance the quality of systematic reviews: a survey of systematic review authors
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Clinical study reports (CSRs) are produced for marketing authorisation applications. They often
contain considerably more information about, and data from, clinical trials than corresponding journal publications. Use
of data from CSRs might help circumvent reporting bias, but many researchers appear to be unaware of their existence
or potential value. Our survey aimed to gain insight into the level of familiarity, understanding and use of CSRs, and to
raise awareness of their potential within the systematic review community. We also aimed to explore the potential
barriers faced when obtaining and using CSRs in systematic reviews.
Methods: Online survey of systematic reviewers who (i) had requested or used CSRs, (ii) had considered but not used
CSRs and (iii) had not considered using CSRs was conducted. Cochrane reviewers were contacted twice via
the Cochrane monthly digest. Non-Cochrane reviewers were reached via journal and other website postings.
Results: One hundred sixty respondents answered an open invitation and completed the questionnaire; 20/
160 (13%) had previously requested or used CSRs and other regulatory documents, 7/160 (4%) had considered but not
used CSRs and 133/160 (83%) had never considered this data source. Survey respondents mainly sought data from the
European Medicines Agency (EMA) and/or the Food and Drug Administration (FDA). Motivation for using CSRs
stemmed mainly from concerns about reporting bias 11/20 (55%), specifically outcome reporting bias 11/20
(55%) and publication bias 5/20 (25%). The barriers to using CSRs noted by all types of respondents included
current limited access to these documents (43 respondents), the time and resources needed to obtain and
include these data in evidence syntheses (n = 25) and lack of guidance about how to use these sources in
systematic reviews (n = 26).
Conclusions: Most respondents (irrespective of whether they had previously used them) agreed that access
to CSRs is important, and suggest that further guidance on how to use and include these data would help
to promote their use in future systematic reviews. Most respondents who received CSRs considered them to
be valuable in their systematic review and/or meta-analysis
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Aakvaag E
- Abbott B
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- Abicht NJ
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- Aboulhorma A
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- Zhemchugov A
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- Zhong D
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- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
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- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Accuracy versus precision in boosted top tagging with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abdelhameed S
- Abeling K
- Abicht NJ
- Abidi SH
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- De Moura NMJN
- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santis F
- De Santo A
- De Simas Filho EF
- De Sousa MJDCS
- De Souza EEP
- De K
- De RCL
- Dedovich DV
- Degens J
- Deiana AM
- Del Corso F
- Del Peso J
- Del Rio F
- Delagrange L
- Delegido AJG
- Deliot F
- Delitzsch CM
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delsart PA
- Demers S
- Demichev M
- Denisov SP
- Derendarz D
- Derue F
- Dervan P
- Desch K
- Deutsch C
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Luca A
- Di Micco B
- Di Nardo R
- Di Petrillo KF
- Diamantopoulou M
- Dias BP
- Dias FA
- Diaz MA
- Didenko AR
- Didenko M
- Diehl EB
- Dimitriadi C
- Dimitrievska A
- Dingfelder J
- Dingley T
- Dinu I-M
- Dittmeier SJ
- Dittus F
- Divisek M
- Djama F
- Djobava T
- Do Vale TD
- Doglioni C
- Dohnalova A
- Dolejsi J
- Dolezal Z
- Domijan K
- Dominguez LP
- Dona KM
- Donadelli M
- Dong B
- Donini J
- Dopke J
- Doria A
- Dos Santos Fernandes N
- Dos Santos SPA
- Dougan P
- Dova MT
- Doyle AT
- Draguet MA
- Dreyer E
- Drivas-koulouris I
- Drnevich M
- Drozdova M
- du Pree TA
- Du D
- Dubinin F
- Dubovsky M
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Duden ER
- Duflot L
- Duminica I
- Dumitriu AE
- Dunford M
- Dungs S
- Dunne K
- Duperrin A
- Durglishvili A
- Dwyer BL
- Dyckes GI
- Dyndal M
- Dziedzic BS
- Dührssen M
- Düren M
- Earnshaw ZO
- Eberwein GH
- Eckerova B
- Eggebrecht S
- Ehrke LF
- Eigen G
- Einsweiler K
- Ekelof T
- Ekman PA
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Ellis N
- Elmsheuser J
- Elsawy M
- Elsing M
- Emeliyanov D
- Enari Y
- Ene I
- Epari S
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estevez MA
- Etzion E
- Evans G
- Evans H
- Evans LS
- Ezhilov A
- Ezzarqtouni S
- Fabbri F
- Fabbri L
- Facini G
- Fadeyev V
- Fakhrutdinov RM
- Fakoudis D
- Falciano S
- Fallavollita F
- Falsetti G
- Faltova J
- Fan C
- Fan Y
- Fang Y
- Fanti M
- Faraj M
- Farazpay Z
- Farbin A
- Farilla A
- Farkh SE
- Farook MHM
- Farooque T
- Farrington SM
- Fassi F
- Fassouliotis D
- Fawcett WJ
- Fayard L
- Federic P
- Federicova P
- Fedin OL
- Feickert M
- Feligioni L
- Fellers DE
- Feng C
- Feng Z
- Fenton MJ
- Ferencz L
- Ferguson RAM
- Fernandez AA
- Fernoux MJV
- Ferrando J
- Ferrari A
- Ferrari P
- Ferrari R
- Ferreira IS
- Ferrer JAV
- Ferrere D
- Ferretti C
- Fiacco D
- Fiedler F
- Fiedler P
- Filho LEB
- Filipčič A
- Filmer EK
- Filthaut F
- Fiolhais MCN
- Fiorini L
- Fisher WC
- Fitschen T
- Fitzhugh PM
- Fleck I
- Fleischmann P
- Flick T
- Flores CAA
- Flores M
- Follega FM
- Fomin N
- Foo JH
- Formica A
- Forti AC
- Fortin E
- Fortman AW
- Foti MG
- Fountas L
- Fournier D
- Fox H
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- Francescato S
- Franchellucci S
- Franchini M
- Franchino S
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- Franco L
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- Franklin M
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- Frost JA
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- Gabrielli A
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- Gagliardi G
- Gagnon LG
- Gaid S
- Galantzan S
- Gallas EJ
- Gallop BJ
- Gan KK
- Ganguly S
- Gao Y
- Garcia B
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- Garcia LC
- Garcia YR
- Garcia-Sciveres M
- García C
- Gardner GL
- Gardner RW
- Garelli N
- Garg D
- Garg RB
- Gargan JM
- Garner CA
- Garrido SF
- Garvey CM
- Garzon GOY
- Gassmann VK
- Gaudio G
- Gautam V
- Gauzzi P
- Gavranovic J
- Gavrilenko IL
- Gavrilyuk A
- Gay C
- Gaycken G
- Gazis EN
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- Gee CM
- Gekow A
- Gemme C
- Genest MH
- Gentry AD
- George S
- George WF
- Geralis T
- Gessinger-Befurt P
- Geyik ME
- Ghani M
- Ghazali YE
- Ghorbanian K
- Ghosal A
- Ghosh A
- Ghosh A
- Giacobbe B
- Giagu S
- Giani T
- Giannelli MF
- Giannini A
- Gibson SM
- Gignac M
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- Gilbert AK
- Gilbert BJ
- Gillberg D
- Gilles G
- Gimenez VC
- Ginabat L
- Gingrich DM
- Giordani MP
- Giraud PF
- Giugliarelli G
- Giugni D
- Giuli F
- Gkialas I
- Gladilin LK
- Glasman C
- Gledhill GR
- Glemža G
- Glisic M
- Gnesi I
- Go Y
- Goblirsch-Kolb M
- Gocke B
- Godin D
- Gokturk B
- Goldfarb S
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- Gololo MGD
- Golubkov D
- Gombas JP
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- Gongadze A
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- Gonzalez-Sevilla S
- Gonçalo R
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- Gorini B
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- Goshaw AT
- Gostkin MI
- Goswami S
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- Goussiou AG
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- Gregor IM
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- Gross E
- Grosse-Knetter J
- Grundy JC
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- Guardia AB
- Gudnadottir OS
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- Gugel R
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- Guo F
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- Gurdasani SS
- Gustavino G
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- Hank MD
- Hansen JB
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- Harrison NM
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- Hasan RZ
- Hasegawa Y
- Haslbeck F
- Hassan S
- Hauser R
- Hawkes CM
- Hawkings RJ
- Hayashi Y
- Hayden D
- Hayes C
- Hayes RL
- Hays CP
- Hays JM
- Hayward HS
- He F
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- He Y
- He Y
- Heatley NB
- Hedberg V
- Heggelund AL
- Hehir ND
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- Herten G
- Hertenberger R
- Hervas L
- Hesping ME
- Hessey NP
- Hidaoui M
- Hidic N
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- Hodkinson BH
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- Hsu S-C
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- Huang X
- Huang Y
- Huang Y
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- Huffman TB
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- Hulsken R
- Hurrell LTB
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- Iakovidis G
- Ibanez AP
- Iconomidou-Fayard L
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- Iengo P
- Iglesias JAS
- Iguchi R
- Iiyama Y
- Iizawa T
- Ikegami Y
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- Iodice M
- Ippolito V
- Irwin RK
- Ishino M
- Islam W
- Issever C
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- Ito H
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- Ivina A
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- Jiang C
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- Jimenez AR
- Jiménez YH
- Jin S
- Jinaru A
- Jinnouchi O
- Johansson P
- Johns KA
- Johnson JW
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- Jones E
- Jones KS
- Jones P
- Jones RWL
- Jones TJ
- Joos HL
- Joshi R
- Jovicevic J
- Ju X
- Junggeburth JJ
- Junkermann T
- Juzek MK
- Kabana S
- Kaczmarska A
- Kado M
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- Kagan M
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- Kajomovitz E
- Kakati N
- Kalaitzidou I
- Kalderon CW
- Kang NJ
- Kar D
- Karava K
- Kareem MJ
- Karentzos E
- Karkout O
- Karpov SN
- Karpova ZM
- Kartvelishvili V
- Karyukhin AN
- Kasimi E
- Katzy J
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- Kawade K
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- Kazakos S
- Kazanin VF
- Ke Y
- Keaveney JM
- Keeler R
- Kehris GV
- Keller JS
- Kelly AS
- Kempster JJ
- Kennedy PD
- Kepka O
- Kerridge BP
- Kersten S
- Kerševan BP
- Keszeghova L
- Khan RA
- Khanov A
- Kharlamov AG
- Kharlamova T
- Khoda EE
- Kholodenko M
- Khoo TJ
- Khoriauli G
- Khubua J
- Khwaira YAR
- Kibirige B
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- Klein U
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- Klimentov A
- Klioutchnikova T
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- Knight TM
- Knue A
- Kobylianskii D
- Koch SF
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- Kodyš P
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- Koffas T
- Kolay O
- Koletsou I
- Komarek T
- Kong AXY
- Kono T
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- Kontaxakis P
- Konya B
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- Kostyukhin VV
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- Kotwal A
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- Kourkoumeli-Charalampidi A
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- Kourlitis E
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- Kramarenko VA
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- Latonova V
- Latour BMD
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- Luise I
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- Zaid E
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- Zhao H
- Zhao T
- Zhao Y
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- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
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- Zhong D
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- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- IOP Publishing
- Publication date
- 01/08/2024
- Field of study
Abstract
The identification of top quark decays where the top quark has a large momentum transverse to the beam axis, known as top tagging, is a crucial component in many measurements of Standard Model processes and searches for beyond the Standard Model physics at the Large Hadron Collider.
Machine learning techniques have improved the performance of top tagging algorithms, but the size of the systematic uncertainties for all proposed algorithms has not been systematically studied.
This paper presents the performance of several machine learning based top tagging algorithms on a dataset constructed from simulated proton-proton collision events measured with the ATLAS detector at √
s
= 13 TeV.
The systematic uncertainties associated with these algorithms are estimated through an approximate procedure that is not meant to be used in a physics analysis, but is appropriate for the level of precision required for this study.
The most performant algorithms are found to have the largest uncertainties, motivating the development of methods to reduce these uncertainties without compromising performance.
To enable such efforts in the wider scientific community, the datasets used in this paper are made publicly available.</jats:p
Work-life balance policies in high performance organisations: A comparative interview study with millennials in Dutch consultancies
- Author
- Publication venue
- Publication date
- 01/02/2021
- Field of study
The literature on work-life balance primarily focuses on how individuals cope with high work demands. This study, however, investigates how young professionals experience the work-life balance support offered by organisations. Twenty-four millennial consultants were interviewed to explore their perceptions of work-life balance and organisational support policies in an extreme work context. Twelve consultants worked for strategy houses with an average working week of around 60 hours, while the other 12 worked for general management consultancies with average working weeks of roughly 50 hours. Our comparative findings suggest that overall work-life balance perceptions stay positive in both settings. In strategy houses, where work pressures are highest, reported policies and practices go beyond health programmes, training and coaching, which are the most common work-life balance measures. Strategy houses monitor their consultants’ work-life balance experience weekly, provide options to outsource components of the work, and offer multiple forms of compensation. These further policies are much appreciated. Despite these positive assessments, we also observe an increase of negative work-life balance experiences due to the higher work pressures at strategy houses. There is, therefore, some ambiguity in the work-life balance perceptions of consultants, who recalibrate what are ‘normal’ work demands and reframe and refocus on the bright side of work life. Such occupational ideologies indicate a ‘dirty work’ experience
A new Paravortex (Platyhelminthes, Dalyellioida) endoparasite of Mesodesma mactroides (Bivalvia, Mesodesmatidae) from Uruguay
- Author
- AW Pike
- B Wahl
- CD Zander
- CMC Woods
- Cristina Damborenea
- D Atkins
- E Linton
- F Cremonte
- F Cremonte
- Francisco Brusa
- I Belofastova
- JB Jennings
- JB Jennings
- JT Patterson
- L Szidat
- LC Fleming
- LC Fleming
- LRG Cannon
- LRG Cannon
- MJ Carballal
- N Noury-Sraïri
- N Noury-Sraïri
- O Defeo
- P Hallez
- PE Gibbs
- RFH Freeman
- Rodrigo Ponce de León
- SC Ball
- SM Fiori
- WH Leigh-Sharpe
- WJ Wardle
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Work-life balance policies in high performance organisations: A comparative interview study with millennials in Dutch consultancies
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
BAG3 mutation in a patient with atypical phenotypes of myofibrillar myopathy and Charcot–Marie–Tooth disease
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Is there a selection bias in roll call votes? Evidence from the European Parliament
- Author
- A Kreppel
- A Kreppel
- A Noury
- Abdul Noury
- B Høyland
- C Carrubba
- C Carrubba
- C Schonhardt-Bailey
- Erik Voeten
- F Attinà
- Gerard Roland
- GW Cox
- GW Cox
- H Rosenthal
- H Rosenthal
- J Angrist
- J Snyder
- J Snyder
- Jason M Roberts
- JB Londregan
- JM Carey
- JM Carey
- K Koford
- K Krehbiel
- K Krehbiel
- KT Poole
- KT Poole
- KT Poole
- LE Papke
- M Mühlböck
- N McCarty
- R Fisman
- S Hix
- S Hix
- S Hix
- S Hix
- S Hix
- S Hug
- S Hug
- S Hug
- S Morgenstern
- SA Rice
- Simon Hix
- Tapio Raunio
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
European Medicines Agency Policy 0070: an exploratory review of data utility in clinical study reports for academic research
- Author
- A Hodkinson
- A Hodkinson
- B Wieseler
- B Wieseler
- C Tudur Smith
- D Eyding
- DA Zarin
- E Maund
- E Maund
- E Maund
- European Medicines Agency
- H JPT
- J Le Noury
- JB Schroll
- Jean-Marc Ferran
- JJ Kirkham
- JLK Beaumier
- K Dwan
- L Kniola
- M Kohler
- Organisation for Economic Cooperation and Development
- Peter Doshi
- S Bonini
- Sarah J. Nevitt
- SJ Nevitt
- SS Vedula
- T Jefferson
- T Jefferson
- T Jefferson
- Tom Jefferson
- V Musini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The DM-scope registry: a rare disease innovative framework bridging the gap between research and medical care
- Author
- Attarian S
- Aube-Nathier Ac
- Audic F
- Bach N
- Barnerias C
- Bassez G
- Bedat-Millet Al
- Behin A
- Bellance R
- Ben Yaou R
- Bombard V
- Bouhour F
- Boutte C
- Boyer F
- Cances C
- Chabrol B
- Chanson Jb
- Chapon F
- Chasseriau R
- Cintas P
- Cobo Am
- Colombert V
- Cruz Mc
- Cuisset Jm
- de Antonio M
- Deschamps R
- Desguerre I
- Dogan C
- Durigneux J
- Duval F
- Espil C
- Eymard B
- Fafin C
- Feasson L
- Fradin M
- Furby A
- Gagnon C
- Ghorab K
- Goldenberg A
- Grotto S
- Guyant-Marechal L
- Hamroun D
- Heron D
- Isapof A
- Jacquin-Piques A
- Journel H
- Laforet P
- Lagrue E
- Laroche-Raynaud C
- Laugel V
- Lebeau F
- Magot A
- Manel V
- Mathieu J
- Mayer M
- Menard D
- Mercier S
- Michaud M
- Minot Mc
- Morales Rj
- Nadaj-Pakleza A
- Noury Jb
- Pasquier L
- Pellieux S
- Pereon Y
- Perrier J
- Peudenier S
- Pouget J
- Preudhomme M
- Puymirat J
- Quijano-Roy S
- Ragot-Mandry S
- Richelme C
- Rivier F
- Sabouraud P
- Sacconi S
- Salort-Campana E
- Sarret C
- Schaeffer S
- Sole G
- Stojkovic T
- Taithe F
- Testard H
- Tiffereau V
- Urtizberea A
- Vanhulle C
- Vial C
- Walther-Louvier U
- Zagnoli F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2019
- Field of study
International audienceBackground: The relevance of registries as a key component for developing clinical research for rare diseases (RD) and improving patient care has been acknowledged by most stakeholders. As recent studies pointed to several limitations of RD registries our challenge was (1) to improve standardization and data comparability; (2) to facilitate interoperability between existing RD registries; (3) to limit the amount of incomplete data; (4) to improve data quality. This report describes the innovative concept of the DM-Scope Registry that was developed to achieve these objectives for Myotonic Dystrophy (DM), a prototypical example of highly heterogeneous RD. By the setting up of an integrated platform attractive for practitioners use, we aimed to promote DM epidemiology, clinical research and patients care management simultaneously.Results: The DM-Scope Registry is a result of the collaboration within the French excellence network established by the National plan for RDs. Inclusion criteria is all genetically confirmed DM individuals, independently of disease age of onset. The dataset includes social-demographic data, clinical features, genotype, and biomaterial data, and is adjustable for clinical trial data collection. To date, the registry has a nationwide coverage, composed of 55 neuromuscular centres, encompassing the whole disease clinical and genetic spectrum. This widely used platform gathers almost 3000 DM patients (DM1 n = 2828, DM2 n = 142), both children (n = 322) and adults (n = 2648), which accounts for > 20% of overall registered DM patients internationally. The registry supported 10 research studies of various type i.e. observational, basic science studies and patient recruitment for clinical trials.Conclusion: The DM-Scope registry represents the largest collection of standardized data for the DM population. Our concept improved collaboration among health care professionals by providing annual follow-up of quality longitudinal data collection. The combination of clinical features and biomolecular materials provides a comprehensive view of the disease in a given population. DM-Scope registry proves to be a powerful device for promoting both research and medical care that is suitable to other countries. In the context of emerging therapies, such integrated platform contributes to the standardisation of international DM research and for the design of multicentre clinical trials. Finally, this valuable model is applicable to other RDs
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