Building the Future of Healthcare

The Wexner Medical Center (WMC) at The Ohio State University (OSU) is a non-profit, academic medical center serving central and southern Ohio. WMC is a large system with 6 hospitals and a vast support network of healthcare providers and researcher. This presentation contains an overview of OSUWMC and its strategic plans, key result areas and challenges it will face during its ongoing growth and development as a premiere health system.https://fuse.franklin.edu/ss2014/1067/thumbnail.jp

Aircraft Leasing—How to Comply with the Regulations and What Happens When You Don’t

The Federal Aviation Administration’s (FAA) increased emphasis on investigating improper leasing/illegal charter presents a challenge for aircraft operators. Understanding the regulatory requirements related to aircraft leasing is critical for operators to ensure their aircraft operations are compliant. Equally important is the need for aircraft operators to understand how the FAA exercises its oversight when it investigates alleged improper leasing/illegal charter operations, the consequences to which an aircraft operator may be subject in the event of non-compliance, and how an operator who is the target of such an investigation may respond to and/or work with the FAA to successfully resolve the investigation

The Fulbright International Education Administrators Seminars: Pathways to International Partnerships

While the benefits of studying abroad are well documented (e.g., Braskamp et al.; Lewis and Niesenbaum; Ludlum et al.; McCabe; Williams), honors administrators face significant challenges in internationalizing their honors programs and colleges. The U.S. Fulbright Commission, by partnering with commissions in France, Germany, India, Japan, Korea, Russia, and Taiwan to host programs for international education administrators from around the United States each year, is addressing the challenges of internationalizing American higher education. According to the Institute of International Education, the seminar in Germany in 1984–1985 was the first of its kind. Other seminars were added in 1986 (Japan), 1999 (Korea), 2012 (India), 2013 (France), and 2017 (Taiwan) (“The Power”). This chapter provides an overview of the German-American Fulbright Commission’s IEA seminar and outlines the seminar’s benefits and the opportunities it offers honors administrators working to internationalize their programs. The IEA application process requires a project statement, institutional statement, and letters of recommendation, including one from the applicant’s direct supervisor. Effective applications demonstrate an applicant’s “desire to learn about the host country’s education system as well as establish networks of U.S. and international colleagues” (“IEA Review Criteria”). The applicants’ administrative positions and willingness to share knowledge gained through the seminar are other important selection criteria. All applications are initially reviewed by a panel consisting of U.S. Fulbright IEA alumni. Applications are then forwarded to the specific country commission (in our case the German-American Fulbright Commission), which makes the final selection. All travel, accommodations, and program costs are covered by the Fulbright IEA Program

Idiopathic ventricular fibrillation in a previously healthy recreational athlete

There are several clinical challenges in the survivor of sudden cardiac arrest (SCA), including ensuring that a comprehensive diagnostic evaluation has been performed and providing counseling on return to activity. We report a case of a highly conditioned athlete who presented following aborted SCA during exercise with a diagnosis of idiopathic ventricular fibrillation arrest.

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO

A prospective, multicenter, randomized trial was undertaken to compare the efficacy and toxicity of adriamycin with mitoxantrone within a 6-drug combination chemotherapy regimen for elderly patients (older than 60 years) with high-grade non-Hodgkin lymphoma (HGL) given for a minimum of 8 weeks. A total of 516 previously untreated patients aged older than 60 years were randomized to receive 1 of 2 anthracycline-containing regimens: adriamycin, 35 mg/m2 intravenously (IV) on day 1 (n = 259), or mitoxantrone, 7 mg/m2 IV on day 1 (n = 257); with prednisolone, 50 mg orally on days 1 to 14; cyclophosphamide, 300 mg/m2 IV on day 1; etoposide, 150 mg/m2 IV on day 1; vincristine, 1.4 mg/m2 IV on day 8; and bleomycin, 10 mg/m2 IV on day 8. Each 2-week cycle was administered for a minimum of 8 weeks in the absence of progression. Forty-three patients were ineligible for analysis. The overall and complete remission rates were 78% and 60% for patients receiving PMitCEBO and 69% and 52% for patients receiving PAdriaCEBO (P = .05, P = .12, respectively). Overall survival was significantly better with PMitCEBO than PAdriaCEBO (P = .0067). However, relapse-free survival was not significantly different (P = .16). At 4 years, 28% of PAdriaCEBO patients and 50% of PMitCEBO patients were alive (P = .0001). Ann Arbor stage III/IV, World Health Organization performance status 2-4, and elevated lactate dehydrogenase negatively influenced overall survival from diagnosis. In conclusion, the PMitCEBO 8-week combination chemotherapy regimen offers high response rates, durable remissions, and acceptable toxicity in elderly patients with HGL

Large-scale distributions of tropospheric nitric, formic, and acetic acids over the western Pacific basin during wintertime

We report here measurements of the acidic gases nitric (HNO3), formic (HCOOH), and acetic (CH3COOH) over the western Pacific basin during the February-March 1994 Pacific Exploratory Mission-West (PEM-West B). These data were obtained aboard the NASA DC-8 research aircraft as it flew missions in the altitude range of 0.3–12.5 km over equatorial regions near Guam and then further westward encompassing the entire Pacific Rim arc. Aged marine air over the equatorial Pacific generally exhibited mixing ratios of acidic gases \u3c100 parts per trillion by volume (pptv). Near the Asian continent, discrete plumes encountered below 6 km altitude contained up to 8 parts per billion by volume (ppbv) HNO3 and 10 ppbv HCOOH and CH3COOH. Overall there was a general correlation between mixing ratios of acidic gases with those of CO, C2H2, and C2Cl4, indicative of emissions from combustion and industrial sources. The latitudinal distributions of HNO3 and CO showed that the largest mixing ratios were centered around 15°N, while HCOOH, CH3COOH, and C2Cl4 peaked at 25°N. The mixing ratios of HCOOH and CH3COOH were highly correlated (r2 = 0.87) below 6 km altitude, with a slope (0.89) characteristic of the nongrowing season at midlatitudes in the northern hemisphere. Above 6 km altitude, HCOOH and CH3COOH were marginally correlated (r2 = 0.50), and plumes well defined by CO, C2H2, and C2Cl4 were depleted in acidic gases, most likely due to scavenging during vertical transport of air masses through convective cloud systems over the Asian continent. In stratospheric air masses, HNO3 mixing ratios were several parts per billion by volume (ppbv), yielding relationships with O3 and N2O consistent with those previously reported for NOy

Progress in Computational Simulation of Earthquakes

GeoFEST(P) is a computer program written for use in the QuakeSim project, which is devoted to development and improvement of means of computational simulation of earthquakes. GeoFEST(P) models interacting earthquake fault systems from the fault-nucleation to the tectonic scale. The development of GeoFEST( P) has involved coupling of two programs: GeoFEST and the Pyramid Adaptive Mesh Refinement Library. GeoFEST is a message-passing-interface-parallel code that utilizes a finite-element technique to simulate evolution of stress, fault slip, and plastic/elastic deformation in realistic materials like those of faulted regions of the crust of the Earth. The products of such simulations are synthetic observable time-dependent surface deformations on time scales from days to decades. Pyramid Adaptive Mesh Refinement Library is a software library that facilitates the generation of computational meshes for solving physical problems. In an application of GeoFEST(P), a computational grid can be dynamically adapted as stress grows on a fault. Simulations on workstations using a few tens of thousands of stress and displacement finite elements can now be expanded to multiple millions of elements with greater than 98-percent scaled efficiency on over many hundreds of parallel processors (see figure)

Taking the detour

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115976/1/jhm2424.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115976/2/jhm2424-sup-0001-suppinfo.pd

Factors Associated with Potential Medication-Herb/Natural Product Interactions in a Rural Community

Context—Use of both conventional medicines and herbs/natural products are increasing in the United States (US). Consequently, individuals are more likely to be exposed to potentially harmful interactions between these products. Objective—To examine the use of both herbs/natural products and conventional medications in a rural community; examine the prevalence of potential interactions between herbs/natural products and conventional medications; and identify factors associated with exposure to such interactions. Design—Population-based epidemiological study. Setting—Data for this paper were collected between 1999 and 2004 as part of the Johnston County Osteoarthritis Project. Participants—Limited to civilian, non-institutionalized, Caucasian and African American residents, age 45 years or older, of Johnston County, North Carolina. Data used in this paper are from 2,523 individuals who completed face-to-face interviews. Main Outcome Measures—Prevalence of herb/natural product use and exposure to potential interactions between these products and conventional medications. Results—Nineteen percent (n=488) of participants used at least one herb/natural product. Among those who used both conventional medications and herbs/natural products, more than 1 in 5 (97 [21.9%]) were using a combination of products associated with a potential interaction. Odds of exposure to a potential interaction was lower among people who had health insurance and increased with the number of products used. Conclusions—Many people are exposed to potential interactions between herbs/natural products and conventional medications. Research is needed to better understand the effect such interactions may have on patient care