NDM-502: INTEGRATION OF SITE CONDITIONS INFORMATION USING GEOGRAPHIC INFORMATION SYSTEM FOR THE SEISMIC EVALUATION OF BRIDGES

While seismic hazard is generally moderate in eastern Canada, the seismic risk in urban area is increased by the density of the population, the value and the age of the infrastructure and the relative importance of the economic activities. Among the consequences of a seismic event, damages to infrastructures, such as bridges and overpasses, may compromise the safety of users and the free movement of people and goods. According to modern seismic codes and regulations, structures designed for seismic loading should sustain moderate to severe earthquakes with minimal and reparable damages and without collapse. However, older structures build prior to the introduction of seismic requirements in codes and standards, are more vulnerable and exposed to a high seismic risk. Geotechnical and geological site conditions may result in severe damages to the structures and contribute to their seismic vulnerability. This project proposes to extract these information using geographical information system (GIS) tools at the bridge sites and integrate this information in the seismic evaluation procedures. Local soil amplification and induced effects are integrated into scoring evaluation procedures and seismic risk studies. In this paper, the amplification phenomenon will be investigated by the compilation of existing data for the Saint-Lawrence valley and ambient noise measurements on soil and bridges. The aim of this study is to develop a susceptibility scale to the amplification effect based on GIS information. The results will contribute to a better estimation of the seismic vulnerability of bridges and overpasses to prioritize mitigation as well as post-earthquake interventions

STR-921: EFFECT OF NON-STRUCTURAL COMPONENTS ON THE MODAL PROPERTIES OF BUILDINGS USING AMBIENT VIBRATION TESTING

This paper illustrates the effect of non-structural components on the variation of dynamic properties of buildings in the elastic range using ambient vibration testing. A six-storey reinforced concrete building that forms part of the École de Technologie Supérieure campus was studied. Ambient vibration tests were conducted on this building during its construction and once finished. Measured records at different floor levels served to extract the natural frequencies, mode shapes and damping ratios of the building. Values obtained for the studied building, both at bare frame and finished phases were then compared. Calculated differences in the natural frequencies of the building range between 1.6 % and 21.7 %. Results highlight the importance of considering the contribution of non-structural components such as glass, facades and partition walls in the process of structural analysis and modeling of buildings

Impact of initial stress field heterogeneity in dynamic soil–structure interaction

This article covers the impact of soil initial stress field heterogeneity (ISFH) in wave-passage analysis and in prescribed structural acceleration in the context of dynamic soil–structure interaction (DSSI) analysis. ISFH is directly related to the natural behavior of soil where a significant increase in net effective confinement, as is the case in the foundation soil under a building, tends to increase the soil’s modulus and strain. This creates a heterogeneous stress field in the vicinity of the foundation elements, which results in a modification of the dynamic behavior of the soil–structure system. A simple method for considering the impact of ISFH on the value of the soil’s modulus and strain was developed using the direct DSSI approach. The method was used to analyze numerical artifacts and its impact on the surface acceleration values of a nonlinear two-dimensional (2D) numerical soil deposit under transient loading. This analysis was followed by a sample application for a three-story, three-bay concrete moment-resisting frame structure erected on a deep soil deposit. Floor acceleration and relative displacement were used for comparison. The soil deposit was modeled using the typical geotechnical properties of fine-grained, post-glacial soil samples obtained in Eastern Canada from in situ geotechnical borehole drilling, geophysical surveys, and laboratory testing. Ground motion was based on eastern calibrated seismic signals. The results of the soil deposit analysis show that ISFH had a significant impact on surface acceleration values. The effect was found to be period-dependent and to have a direct impact on prescribed acceleration values at the base of structure. Thus, failure to take the effects of ISFH into consideration can lead to errors in calculating prescribed structural accelerations (i.e. over- or underestimation). -- Keywords : Dynamic soil–structure interaction ; direct modeling ; finite element ; Eastern Canada ; post-glacial deposits

Dropout from exercise trials among cancer survivors—An individual patient data meta-analysis from the POLARIS study

Introduction: The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods: This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients without metastatic disease randomized to an exercise arm were included. Harmonized studies included a pre and a posttest, and participants were classified as dropouts when missing all assessments at the post-intervention test. Subgroups were identified with a conditional inference tree. Results: Overall, 9.6% of the participants dropped out. Five subgroups were identified in the conditional inference tree based on four significant associations with dropout. Most dropout was observed for participants with BMI &gt;28.4 kg/m2, performing supervised resistance or unsupervised mixed exercise (19.8% dropout) or had low-medium education and performed aerobic or supervised mixed exercise (13.5%). The lowest dropout was found for participants with BMI &gt;28.4 kg/m2 and high education performing aerobic or supervised mixed exercise (5.1%), and participants with BMI ≤28.4 kg/m2 exercising during (5.2%) or post (9.5%) treatment. Conclusions: There are several systematic differences between cancer survivors completing and dropping out from exercise trials, possibly affecting the external validity of exercise effects.</p

Moderators of Exercise Effects on Cancer-related Fatigue:A Meta-analysis of Individual Patient Data

PURPOSE: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCT) to investigate moderators of exercise intervention effects on cancer-related fatigue. METHODS: We used individual patient data from 31 exercise RCT worldwide, representing 4366 patients, of whom 3846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test. RESULTS: Exercise interventions had statistically significant beneficial effects on fatigue (β = -0.17; 95% confidence interval [CI], -0.22 to -0.12). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference = -0.18; 95% CI -0.28 to -0.08). Supervised interventions with a duration ≤12 wk showed larger effects on fatigue (β = -0.29; 95% CI, -0.39 to -0.20) than supervised interventions with a longer duration. CONCLUSIONS: In this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration

Targeting exercise interventions to patients with cancer in need:An individual patient data meta-analysis

Background: Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods: Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided. Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction &lt; .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction &lt; .001) were greater in patients with worse baseline values. Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment

Design of the EXercise Intervention after Stem cell Transplantation (EXIST) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of an individualized high intensity physical exercise program on fitness and fatigue in patients with multiple myeloma or (non-) Hodgkin's lymphoma treated with high dose chemotherapy and autologous stem cell transplantation

<p>Abstract</p> <p>Background</p> <p>The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be beneficial for physical fitness, fatigue and quality of life. However, the trials conducted so far to test the effects of physical exercise interventions in this group of patients were of poor to moderate methodological quality and economic evaluations are lacking. Hence there is need for a rigorous, appropriately controlled assessment of the effectiveness of exercise programs in these patients. The aims of the present study are (1) to determine the effectiveness of an individualized high intensity strength and interval training program with respect to physiological and psychological health status in patients with multiple myeloma or (non-)Hodgkin's lymphoma who have recently undergone high dose chemotherapy followed by autologous stem cell transplantation; and (2) to evaluate the cost-effectiveness of this program.</p> <p>Methods</p> <p>A multicenter, prospective, single blind randomized controlled trial will be performed. We aim to recruit 120 patients within an inclusion period of 2 years at 7 hospitals in the Netherlands. The patients will be randomly assigned to one of two groups: (1) intervention plus usual care; or (2) usual care. The intervention consists of an 18-week individualized supervised high-intensity exercise program and counselling. The primary outcomes (cardiorespiratory fitness, muscle strength and fatigue) and secondary outcomes are assessed at baseline, at completion of the intervention and at 12 months follow-up.</p> <p>Discussion</p> <p>The strengths of this study include the solid trial design with clearly defined research groups and standardized outcome measures, the inclusion of an economic evaluation and the inclusion of both resistance and endurance exercise in the intervention program.</p> <p>Trial registration</p> <p>This study is registered at the Netherlands Trial Register (NTR2341)</p

Effects and moderators of exercise on quality of life and physical function in patients with cancer:An individual patient data meta-analysis of 34 RCTs

This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n=4,519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (β=0.15, 95%CI=0.10;0.20) and PF (β=0.18,95%CI=0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (βdifference_in_effect=0.13, 95%CI=0.03;0.22) and PF (βdifference_in_effect=0.10, 95%CI=0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care

Behaviour of wall-frame structures : a study of the interactive behaviour of continuous and discontinuous wall-frame structures

The horizontal interaction between the walls and frames in wall-frame structures is investigated to determine its role in stiffening the structure against lateral, wind or earthquake loading. Discontinuous wall-frame structures are studied to assess the effects of the discontinuities on the horizontal interaction, and on the structures' lateral stiffness. The discontinuities include stepped walls or frames, curtailed walls, and different configurations of stiffened-storey frames.In each case, a continuum solution is developed and used to describe the behaviour of the structure, and to evaluate the effects of the discontinuities. Corresponding discrete finite elements analyses are also performed to verify the accuracy of the algebraic solutions and to determine the nature and magnitude of the resulting effects.For stepped and curtailed wall-frame structures, it is found that the walls can be reduced or curtailed without modifying significantly the overall horizontal interaction and lateral stiffness. It is found that for stiffened-storey frame structures, the horizontal interaction and lateral stiffness are significantly increased. This constitutes an entirely new type of high-rise wall-frame structure of greater efficiency

Development of an index assignment procedure compatible with the regional seismicity in the province of Quebec for the rapid visual assessment of existing buildings

In the context of the seismic vulnerability evaluation of buildings, the score assignment method can be used as the first step of a multiphase procedure aimed at identifying hazardous buildings that must then be analysed in greater detail. Because the existing Canadian rapid visual screening procedure has not been updated since 1992, a new procedure is proposed based on a set of vulnerability indices for different cities in the province of Quebec. A seismicity level (low, moderate, or high) is attributed to each city using the spectral acceleration response values included in the 2005 edition of National building code of Canada (NBCC) and the criteria proposed in FEMA 310 Handbook for the seismic evaluation of buildings - a prestandard. The structural vulnerability indices (SVIs) are calculated using the recently improved nonlinear static analysis procedure in FEMA 440, Improvement of nonlinear static seismic analysis procedures for each seismicity level. The NBCC 2005 reference soil class C is considered in the calculation of the SVIs, and index modifiers for the building height, irregularities, and design and construction year. The application of these indices to the estimation of the probable damage distribution in building inventories is discussed at the end