Território costeiro em transformação: investigação sobre os processos de crescimento das estruturas urbano-turísticas no município de Laguna - Brasil

O turismo é estabelecido como opção de lazer, principalmente junto às zonas costeiras, onde há a presença do sol, do mar e magníficas paisagens. Este é um fato ocorrido em nível global e observado também junto às ocupações da costa brasileira. A massificação desta atividade tem gerado impactos nas cidades litorâneas que vêm apresentando um crescimento acelerado devido à intensa especulação imobiliária nestas áreas, muitas vezes, desconsiderando questões ambientais, estruturas urbanas pré-existentes e também suas paisagens (elementos geradores de identidade a estas regiões). A cidade de Laguna, sul do Brasil, passa por um processo similar, onde a urbanização costeira tem avançado bastante em função da busca deste município como destino turístico. O presente artigo se propõe a identificar os tipos de ocupação existentes neste território costeiro, originados por distintos processos de crescimento, geradores de espaços públicos diferenciados, e com distintos impactos junto ao meio físico onde foram implantados.Tourism is established as a leisure option, especially along the coastal areas, surrounded by the presence of the sun, the sea, and magnificent views. It is a fact that occurs globally and also observed at the occupations of the Brazilian coast. The overcrowding of this activity has generated impacts in coastal cities that have shown an accelerated growth due to intense speculation in these areas along the coast often disregarding environmental issues, pre-existing urban structures and also its landscapes (generating elements of identity to these regions). The city of Laguna, south of Brazil, goes through a similar process where the coastal urbanization has advanced a lot according to demand of this city as a tourist destination. This article aims to identify the types of occupation in this city, caused by different growth processes, different public spaces generators, as well as its impact with the physical environment where they were deployed

Pau pra toda obra: o uso da madeira na arquitetura catarinense

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Urbanismo, historia e arquitetura da cidadeEsta pesquisa aborda como a madeira tem sido utilizada na produção da arquitetura em algumas regiões do Estado de Santa Catarina. Num primeiro momento, apresenta-se uma conceituação sobre o material e os produtos para a construção que dele derivam e as diferentes técnicas construtivas envolvendo sua utilização. Para compreender a produção de arquitetura em madeira elaborou-se um breve histórico reconhecendo sua utilização na América Latina e no Brasil, com um enfoque maior para a região sul do país. Questões políticas sobre o déficit habitacional e questões ambientais também estão sendo consideradas nesta pesquisa, uma vez que a madeira pode estar envolvida com a primeira questão e está diretamente relacionada às questões que envolvem o meio-ambiente. Estudos de casos de arquitetura popular e arquitetura erudita em madeira são apresentados como exemplos do duplo papel assumido por este material.This research focuses on how wood is being used in the production of architecture in some regions of the state of Santa Catarina. Firstly, the materials and related products, as well as the many different construction techniques in which they are used, are conceptualized. A brief history of the production of wood architecture in Latin America and more specifically Brazil (focusing above all on the south region) is then offered. Political issues such as housing shortage and environmental concerns are also taken into account, given that wood may be involved in the first and is directly related to the latter. Case studies of popular and scholarly architecture are presented to illustrate the double role assumed by this materia

Apreensão da transformação do território costeiro de Laguna – Brasil: estudo comparativo dos processos de crescimento dos balneários Farol de Santa Marta e Itapirubá

Esta apresentação trata-se de parte de uma pesquisa em andamento junto à UFSC e UDESC que visa compreender os processos de crescimento das estruturas urbano turísticas em Laguna-SC. O objeto deste estudo são os assentamentos Farol de Santa Marta e Itapirubá, nos extremos opostos do município estudado que, a princípio, apresentavam muitas similaridades entre si. O objetivo é elaborar uma leitura urbano-ambiental do território estudado e também testar o método de análise para compreensão do sítio e da realidade destes lugares. Como aporte teórico principal, tem-se o trabalho de Sola Morales y Rubió (1993) que aborda as formas de crescimento urbano. Sua realização foi feita através de leituras e interpretações de três levantamentos aerofotogramétricos e uma imagem de satélite, de diferentes períodos. Os resultados das análises gráficas permitiram a confirmação das similaridades nas origens dos assentamentos e mostraram, que, ao longo dos anos, foram surgindo distinções bastante significativas na configuração destes casos.This presentation is part of an ongoing research between UFSC and UDESC, aiming to understand the processes of growth of urban tourism structures in Laguna-SC. The object of this study is the settlements of Farol de Santa Marta and Itapirubá, at opposite ends of the studied city, which, at first, presented many similarities among themselves. The objective is to elaborate an urban-environmental reading of the studied territory and also to test the method of analysis to understand the site and the reality of these places. As the main theoretical contribution, we have the work of Sola Morales and Rubió (1993) that addresses the forms of urban growth. Its development were made through readings and interpretations of three aerophotogrammetric surveys and satellite images of time spans. The results of the graphical analyzes allowed the confirmation of the similarities in the origins of the settlements and showed that, over the years, there were quite significant distinctions in the configuration of these cases

A PRAÇA, A POÉTICA E OS PROCESSOS DE IDENTIDADE: desvelando aspectos da identidade urbana

A identidade urbana ou os processos urbanos de identidade são abordados por meio da reflexão sobre a vida social numa praça. A Praça Nereu Ramos, situada em Criciúma-SC, não é o objeto deste estudo, mas é o pretexto de uma ampla discussão sobre como os seus usuários ativos e passivos se relacionam com ela e nela. Com a distinção entre espaço e lugar, o estudo aborda o conceito de lugar antropológico e aponta para importantes pistas sobre a praça como lugar incubador de processos de identidade. É o que faz com que um simples espaço se transforme em um lugar pleno de conteúdos simbólicos. Essa passagem da “condição” de espaço para a “condição” de lugar é resultante da fecundação das funcionalidades – frias, calculadas e inóspitas – pela “habitação” do ser humano com sua poética e seus processos de identidade repletos de pulsações e de vida. A praça não é mais espaço de conveniências e funcionalidades, mas lugar de vida, de memória, de saudade e de cultivo pessoal. .A metodologia utilizada foi composta pelas técnicas de observação sistemática e técnica do GAMOC, as quais foram praticadas durante um ano (07/2011-07/1012) e serão explicitadas no interior do texto. As observações foram anotadas no diário de campo e analisadas à luz dos aportes teóricos aqui apresentados

Híbridos de Milho Afetam a Quantidade de Etanol Produzida no Cerrado do Centro-Oeste Paulista

The Brazilian sugarcane industry has been using corn for the production of ethanol because it has a 120 day vegetative cycle, cultivation in sugarcane renovation areas, and its grains can be stored for long periods of time. In this sense, the objective of the research was to evaluate the agronomic characteristics of three corn hybrids, and the grain processing reflexes for ethanol production. The experiment was installed in the experimental farm of the Sacred Heart University (USC) located in the municipality of Agudos in the State of São Paulo in the 2016/2017 harvest. The experimental area was 8000m2, with 16 plots of 450m2 each. Hybrids 2B810PW, 2B633PW and 2B587PW were used. The planting was carried out in October 2016 and the harvest occurred at 150 days after sowing (d.a.s.). During development of the culture (45, 75, 90 and 110 d.a.s.) the biometric parameters were evaluated. The grains were harvested mechanically, ground and immersed in water, adding the α-amylase enzyme, giving the must. The musts were submitted to inoculation by industrial yeast BG-1. The hybrids 2B587PW, 2B633PW and 2B810PW resulted in 3.65, 3.74 and 2.94 t ha-1 of grains, respectively. Average values of 430 L of ethanol recovered per processed were observed. It is concluded that the hybrid 2B633PW is the most suitable for the cultivation in the center-west of São Paulo state, because results in higher grain yield. The hybrids show differences in fermentative performance of BG-1 yeast, and the 2B810PW results in higher fermentation efficiency and the amount of ethanol produced per ton of processed corn.O setor sucroenergético brasileiro vem utilizando o milho para a produção de etanol por apresentar ciclo vegetativo de 120 dias, cultivo em áreas de renovação de canaviais, e seus grãos podem ser armazenados por longos períodos de tempo. Neste sentido, o objetivo da pesquisa foi avaliar as características agronômicas de três híbridos de milho, e os reflexos do processamento dos grãos para a produção de etanol. O experimento foi instalado no município de Agudos no Estado de São Paulo na safra 2016/2017. A área experimental foi de 8.000m2, com 12 parcelas de 450m2 cada. Utilizou-se os híbridos 2B587PW, 2B633PW e 2B810PW. O plantio foi realizado em outubro de 2016 e a colheita ocorreu aos 150 dias após a semeadura (DAS). Durante o desenvolvimento da cultura (45, 75, 90 e 110 DAS) avaliou-se os parâmetros biométricos. Os grãos foram colhidos mecanicamente, triturados e imersos em água, adicionando-se a enzima α-amilase, originando o mosto. Os mostos foram submetidos à inoculação pela levedura industrial BG-1. Os híbridos 2B587PW, 2B633PW e 2B810PW resultaram em 3,65, 3,74 e 2,94 t ha-1 de grãos, respectivamente. Observaram-se valores médios de 430 L de etanol recuperados por ha processado. Conclui-se que o híbrido 2B633PW é o mais indicado para o cultivo no centro-oeste paulista, por apresentar maior produtividade de grãos, bem como há reflexos dos híbridos de milho processados sob o desempenho fermentativo da levedura BG-1, sendo o 2B810PW o que resulta em maior eficiência fermentativa e quantidade de etanol produzida por tonelada de milho processada

Peginterferon plus ribavirin and sustained virological response rate in HCV-related advanced fibrosis: a real life study

Background: Tolerance and response to antiviral HCV treatment is poor in advanced fibrosis. The aim of this study was to assess SVR rate and its predictive factors in HCV advanced fibrosis patients treated in real life with full dose PEG-IFN plus RBV and to evaluate the adverse events related to treatment. Methods: A multicentric, retrospective study was conducted at six university hospitals. METAVIR F3 and F4 HCV monoinfected patients who were treated with PEG-IFN and RBV had their data analyzed. A stepwise logistic regression analysis was performed to identify the variables independently related to SVR. Adverse events were recorded during treatment. Results: 308 patients were included, 75% genotype 1 and 23% genotype 3. METAVIR F3 was present in 39% and F4 in 61% of patients. The median Child Pugh score for F4 patients was 5 (5–9). The global SVR rate was 34%, 11% were relapsers and 55% were nonresponders. SVR rates were similar between patients treated with PEG-IFN alfa 2a or alfa 2b (p = 0.24). SVR rates according to Child–Pugh score were 26% (Child A) and 18% (Child B). The independent factors related to SVR in F4 patients were genotype 3, RVR and fewer Child Pugh score points. Treatment interruption occurred in 31% patients and death occurred in 1.9%, all with liver cirrhosis. Conclusion: Treatment of HCV in patients with advanced fibrosis should not be postponed. However, a very careful evaluation of cirrhotic patients must be performed before treatment is indicated and careful monitoring is required during treatment.Universidade Estadual Paulista (UNESP) Botucatu School of MedicineUniversidade Federal do Rio de JaneiroUniversidade Estadual de CampinasUniversidade Federal de São Paulo (UNIFESP)Pontificia Universidade Catolica de São PauloUNIFESPSciEL

Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample

Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention-deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD-PRS) and functional segregation of large-scale brain networks. With this aim, ADHD symptoms score, genetic and rs-fMRI (resting-state functional magnetic resonance image) data obtained in a longitudinal community-based cohort of 227 children and adolescents were analysed. A follow-up was conducted approximately 3 years after the baseline, with rs-fMRI scanning and ADHD likelihood assessment in both stages. We hypothesised a negative correlation between probable ADHD and the segregation of networks involved in executive functions, and a positive correlation with the default-mode network (DMN). Our findings suggest that ADHD-PRS is correlated with ADHD at baseline, but not at follow-up. Despite not surviving for multiple comparison correction, we found significant correlations between ADHD-PRS and segregation of cingulo-opercular networks and DMN at baseline. ADHD-PRS was negatively correlated with the segregation level of cingulo-opercular networks but positively correlated with the DMN segregation. These directions of associations corroborate the proposed counter-balanced role of attentional networks and DMN in attentional processes. However, the association between ADHD-PRS and brain networks functional segregation was not found at follow-up. Our results provide evidence for specific influences of genetic factors on development of attentional networks and DMN. We found significant correlations between polygenic risk score for ADHD (ADHD-PRS) and segregation of cingulo-opercular networks and default-mode network (DMN) at baseline. ADHD-PRS was negatively correlated with the segregation level of cingulo-opercular networks but positively correlated with the DMN segregation

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection