101 research outputs found
Meaning-making from wordless (or nearly wordless) picturebooks: what educational research expects and what readers have to say
Wordless (or nearly wordless) picturebooks are intriguing in terms of how readers make meaning from them. This article offers a conceptualization of existing studies in the field of education that use wordless picturebooks with young readers. While some of these studies contribute to understanding meaning-making, the pragmatic use of wordless picturebooks often does not take account of their particular nature and of the heightened role of the reader, leading to a mismatch between what the picturebook expects from the implied reader and the researchers’ expectations of what ‘real’ readers must do with these books. By highlighting observations from children’s literature scholarship and reader-response studies, this article aims to encourage a more interdisciplinary understanding of meaning-making. It also seeks to persuade educational researchers and mediators to consider investigative approaches that are not based on verbalization but are more in tune with the invitations that wordless picturebooks extend to young readers
El álbum poético en portugués y en español: sinergia estética entre palabras e ilustraciones
Este estudo procurou problematizar a relação textual que se observa entre a palavra e a imagem em um tipo de texto especialmente concebido para crianças: o álbum poético. Para tal, utilizamos alguns exemplos textuais significativos desse subgênero literário/editorial ainda em emergência tanto em Portugal quanto na Espanha, e propusemos uma definição e uma caracterização baseadas no comentário de sequências poéticas nas quais a ilustração sustenta o conteúdo verbal. Efetivamente, centrando a atenção no álbum poético de potencial recepção infanto-juvenil, sugere-se uma análise de diversos tÃtulos de autoria portuguesa e espanhola, assente em uma leitura dialógica do texto verbal e do visual. A sinergia que se concretiza entre as duas componentes enunciadas alicerça essa nova construção estética que tem, na verdade e na sua essência, a poesia como matriz e, em larga medida, é devedora dos efeitos expressivos da metáfora.This study aimed to discuss the relation between words and images in a type of text especially directed to children: the picture-poetry book. From significant examples of this literary subgenre still emerging in both Portugal and Spain, we propose a definition and characterization based on the review of poetic sequences in which illustrations support the verbal content. By focusing on picture-poetry books potentially aimed for adolescents and children, we present an analysis of several titles by Portuguese and Spanish authors, based on the dialogic reading between verbal and visual texts. The synergy found between these two components creates de foundantions of a new aesthetic construction which, in truth and in essence, has poetry as its matrix and owes its expressive effects to metaphors.Este estudio ha tenido como objetivo discutir la relación textual que existe
entre la palabra y la imagen en un tipo texto especialmente creado para
niños: el álbum poético. Para ello, utilizamos algunos ejemplos textuales
significativos de un subgénero literario en emergencia tanto en Portugal
cuanto en España, y hemos propuesto una definición de este subgénero y su
caracterización a partir del comentario de secuencias poéticas en las cuales
la imagen sustenta el contenido verbal. De hecho, centrando la atención en
el álbum poético de potencial recepción infantil y juvenil, proponemos un
análisis de diversos tÃtulos de autorÃa portuguesa y española basado en la
lectura dialógica entre el texto verbal y el texto ilustrativo. La sinergia que
se establece entre estos dos componentes enunciados facilita una nueva
construcción estética que da pie, en su esencia, a un tipo de poesÃa que, en
gran medida, es deudora de los efectos expresivos de la metáfora.CIEC - Centro de Investigação em Estudos da Criança, IE, UMinho (UI 317 da FCT), Portugal. Fundos Nacionais através da FCT (Fundação para a Ciência e a Tecnologia) e cofinanciado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) no âmbito do CIEC (Centro de Investigação em Estudos da Criança, da Universidade do Minho) com a referência POCI-01-0145-FEDER-007562info:eu-repo/semantics/publishedVersio
Expressing ‘The Structure of’ in Homotopy Type Theory
As a new foundational language for mathematics with its very different idea as to the status of logic, we should expect homotopy type theory to shed new light on some of the problems of philosophy which have been treated by logic. In this article, definite description, and in particular its employment within mathematics, is formulated within the type theory. Homotopy type theory has been proposed as an inherently structuralist foundational language for mathematics. Using the new formulation of definite descriptions, opportunities to express ‘the structure of’ within homotopy type theory are explored, and it is shown there is little or no need for this expression
Children’s Stories Supporting the Development of Critical Literacy and Intercultural Understanding
This chapter examines the possibilities of applying children’s storybooks in supporting the development of critical literacy as well as intercultural understanding. Valuing and supporting children’s reading is known to provide understanding and empathy towards other human beings. The chapter focuses on theoretical notions related to promoting critical literacies through children’s storybooks, but also includes practical examples of utilizing multicultural children’s stories. The chapter introduces different strategies that parents and teachers can use to support the development of critical literacy, including critical thinking and understanding multiple perspectives. Focus is especially on young children, because they already are capable of moving beyond what is in front of them on the page. Since children’s storybooks offer possibilities for readers to question implicit assumptions about self and others, books can support readers in becoming more culturally aware and sensitive. Consequently, reading storybooks can affect children’s intercultural understanding, and the role of storybooks in children’s moral development – both shaping and changing attitudes – should be seen as transformative.Peer reviewe
Exact analysis of summary statistics for continuous-time discrete-state Markov processes on networks using graph-automorphism lumping
We propose a unified framework to represent a wide range of continuous-time discrete-state Markov processes on networks, and show how many network dynamics models in the literature can be represented in this unified framework. We show how a particular sub-set of these models, referred to here as single-vertex-transition (SVT) processes, lead to the analysis of quasi-birth-and-death (QBD) processes in the theory of continuous-time Markov chains. We illustrate how to analyse a number of summary statistics for these processes, such as absorption probabilities and first-passage times. We extend the graph-automorphism lumping approach [Kiss, Miller, Simon, Mathematics of Epidemics on Networks, 2017; Simon, Taylor, Kiss, J. Math. Bio. 62(4), 2011], by providing a matrix-oriented representation of this technique, and show how it can be applied to a very wide range of dynamical processes on networks. This approach can be used not only to solve the master equation of the system, but also to analyse the summary statistics of interest. We also show the interplay between the graph-automorphism lumping approach and the QBD structures when dealing with SVT processes. Finally, we illustrate our theoretical results with examples from the areas of opinion dynamics and mathematical epidemiology
Expectation propagation for continuous time stochastic processes
We consider the inverse problem of reconstructing the posterior measure over
the trajec- tories of a diffusion process from discrete time observations and
continuous time constraints. We cast the problem in a Bayesian framework and
derive approximations to the posterior distributions of single time marginals
using variational approximate inference. We then show how the approximation can
be extended to a wide class of discrete-state Markov jump pro- cesses by making
use of the chemical Langevin equation. Our empirical results show that the
proposed method is computationally efficient and provides good approximations
for these classes of inverse problems
Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies have been limited by the inability to simultaneously account for HIV codon covariation, linkage disequilibrium among HLA alleles, and the confounding effects of HIV phylogeny when attempting to identify HLA-associated viral evolution. We have developed a statistical model of evolution, called a phylogenetic dependency network, that accounts for these three sources of confounding and identifies the primary sources of selection pressure acting on each HIV codon. Using synthetic data, we demonstrate the utility of this approach for identifying sites of HLA-mediated selection pressure and codon evolution as well as the deleterious effects of failing to account for all three sources of confounding. We then apply our approach to a large, clinically-derived dataset of Gag p17 and p24 sequences from a multicenter cohort of 1144 HIV-infected individuals from British Columbia, Canada (predominantly HIV-1 clade B) and Durban, South Africa (predominantly HIV-1 clade C). The resulting phylogenetic dependency network is dense, containing 149 associations between HLA alleles and HIV codons and 1386 associations among HIV codons. These associations include the complete reconstruction of several recently defined escape and compensatory mutation pathways and agree with emerging data on patterns of epitope targeting. The phylogenetic dependency network adds to the growing body of literature suggesting that sites of escape, order of escape, and compensatory mutations are largely consistent even across different clades, although we also identify several differences between clades. As recent case studies have demonstrated, understanding both the complexity and the consistency of immune escape has important implications for CTL-based vaccine design. Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes
Analysis of the Effects of Polymorphism on Pollen Profilin Structural Functionality and the Generation of Conformational, T- and B-Cell Epitopes
An extensive polymorphism analysis of pollen profilin, a fundamental regulator of the actin cytoskeleton dynamics, has been performed with a major focus in 3D-folding maintenance, changes in the 2-D structural elements, surface residues involved in ligands-profilin interactions and functionality, and the generation of conformational and lineal B- and T-cell epitopes variability.
Our results revealed that while the general fold is conserved among profilins, substantial structural differences were found, particularly affecting the special distribution and length of different 2-D structural elements (i.e. cysteine residues), characteristic loops and coils, and numerous micro-heterogeneities present in fundamental residues directly involved in the interacting motifs, and to some extension these residues nearby to the ligand-interacting areas. Differential changes as result of polymorphism might contribute to generate functional variability among the plethora of profilin isoforms present in the olive pollen from different genetic background (olive cultivars), and between plant species, since biochemical interacting properties and binding affinities to natural ligands may be affected, particularly the interactions with different actin isoforms and phosphoinositides lipids species.
Furthermore, conspicuous variability in lineal and conformational epitopes was found between profilins belonging to the same olive cultivar, and among different cultivars as direct implication of sequences polymorphism. The variability of the residues taking part of IgE-binding epitopes might be the final responsible of the differences in cross-reactivity among olive pollen cultivars, among pollen and plant-derived food allergens, as well as between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients. Identification and analysis of commonly shared and specific epitopes in profilin isoforms is essential to gain knowledge about the interacting surface of these epitopes, and for a better understanding of immune responses, helping design and development of rational and effective immunotherapy strategies for the treatment of allergy diseases. [EN]This study was supported by the following European Regional Development Fund co-financed grants: MCINN BFU 2004-00601/BFI, BFU 2008-00629, BFU2011-22779, CICE (Junta de AndalucÃa) P2010-CVI15767, P2010-AGR6274 and P2011-CVI-7487, and by the coordinated project Spain/Germany MEC HA2004-0094. JCJ-L thanks Spanish CSIC and the European Marie Curie research program for his I3P-BPD-CSIC, and PIOF-GA-2011-301550 grants, respectively.Peer reviewe
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