Evaluating the Contextual Integrity of Privacy Regulation: Parents' IoT Toy Privacy Norms Versus COPPA

Increased concern about data privacy has prompted new and updated data protection regulations worldwide. However, there has been no rigorous way to test whether the practices mandated by these regulations actually align with the privacy norms of affected populations. Here, we demonstrate that surveys based on the theory of contextual integrity provide a quantifiable and scalable method for measuring the conformity of specific regulatory provisions to privacy norms. We apply this method to the U.S. Children's Online Privacy Protection Act (COPPA), surveying 195 parents and providing the first data that COPPA's mandates generally align with parents' privacy expectations for Internet-connected "smart" children's toys. Nevertheless, variations in the acceptability of data collection across specific smart toys, information types, parent ages, and other conditions emphasize the importance of detailed contextual factors to privacy norms, which may not be adequately captured by COPPA.Comment: 18 pages, 1 table, 4 figures, 2 appendice

The connections of party brokers

Seminal models of clientelism assert that parties value brokers for their strong downward ties to voters. Despite its dominance, scholars have not empirically scrutinized key assumptions of this theory due to the challenges of measuring brokers' network connections. We analyze unique data from three sources-Ghana's voter register, a handmade catalogue of local elites, and a large-scale survey of aspiring party brokers. We show that the observable implications of the standard model do not hold: brokers know surprisingly few voters, brokers with more downward connections are not the most active or effective, and parties do not select the brokers who know the most voters. Instead, brokers with the most upward connections to local elites appear to be the most valuable to parties. We build inductively from these results to develop an alternative theory of brokers, proposing that many parties value "problem solvers" over "monitors.

Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage

OBJECTIVES/HYPOTHESIS: Adipose-derived mesenchymal stem cells (ASCs) are an exciting potential cell source for tissue engineering because cells can be derived from the simple excision of autologous fat. This study introduces a novel approach for tissue-engineering cartilage from ASCs and a customized collagen oligomer solution, and demonstrates that the resultant cartilage can be used for laryngeal cartilage reconstruction in an animal model. STUDY DESIGN: Basic science experimental design. METHODS: ASCs were isolated from F344 rats, seeded in a customized collagen matrix, and cultured in chondrogenic differentiation medium for 1, 2, and 4 weeks until demonstrating cartilage-like characteristics in vitro. Large laryngeal cartilage defects were created in the F344 rat model, with the engineered cartilage used to replace the cartilage defects, and the rats followed for 1 to 3 months. Staining examined cellular morphology and cartilage-specific features. RESULTS: In vitro histological staining revealed rounded chondrocyte-appearing cells evenly residing throughout the customized collagen scaffold, with positive staining for cartilage-specific markers. The cartilage was used to successfully repair large cartilaginous defects in the rat model, with excellent functional results. CONCLUSIONS: This study is the first study to demonstrate, in an animal model, that ASCs cultured in a unique form of collagen oligomer can create functional cartilage-like grafts that can be successfully used for partial laryngeal cartilage replacement

Iterated Decomposition of Biased Permutations via New Bounds on the Spectral Gap of Markov Chains

The spectral gap of a Markov chain can be bounded by the spectral gaps of constituent "restriction" chains and a "projection" chain, and the strength of such a bound is the content of various decomposition theorems. In this paper, we introduce a new parameter that allows us to improve upon these bounds. We further define a notion of orthogonality between the restriction chains and "complementary" restriction chains. This leads to a new Complementary Decomposition theorem, which does not require analyzing the projection chain. For $\epsilon$-orthogonal chains, this theorem may be iterated $O(1/\epsilon)$ times while only giving away a constant multiplicative factor on the overall spectral gap. As an application, we provide a $1/n$-orthogonal decomposition of the nearest neighbor Markov chain over $k$-class biased monotone permutations on [$n$], as long as the number of particles in each class is at least $C\log n$. This allows us to apply the Complementary Decomposition theorem iteratively $n$ times to prove the first polynomial bound on the spectral gap when $k$ is as large as $\Theta(n/\log n)$. The previous best known bound assumed $k$ was at most a constant

Expanding faculty development through capacity-building: An institutional case study

The global pandemic highlighted the need for diverse faculty development partners to ensure student and faculty learning was supported, particularly in intensive modes of educational delivery. Our paper presents an institutional case study of how educational technology, in collaboration with the Center for Teaching and Learning and subject matter experts, served as untapped providers of faculty development. We detail the decision to shift to an intensive 7-week module system rather than our traditional 15-week semester in response to COVID-19. Although challenging for both faculty and students, this shift in educational delivery facilitated innovative approaches to faculty and student learning that are present on our campus today. This institutional case study highlights the role that capacity-building plays in capability development and professional learning for faculty and students alike to support effective teaching practice across diverse delivery modes

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes.

BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade. Our aim was to evaluate the expression of programmed death-ligand 1 (PD-L1), programmed cell death protein 1 (PD-1), and presence of CD8+ tumor infiltrating lymphocytes (TILs) in MPNST, and correlate these findings with clinical behavior and outcome.ResultsPD-L1 staining of at least 1% was seen in 0/20 nerves, 2/68 benign lesions and 9/53 MPNST. Two of 68 benign lesions and 7/53 (13%) MPNST had at least 5% PD-L1 staining. CD8 staining of at least 5% was seen in 1/20 (5%) nerves, 45/68 (66%) benign lesions and 30/53 (57%) MPNST. PD-L1 was statistically more prevalent in MPNST than both nerves and benign lesions (p=0.049 and p=0.008, respectively). Expression of PD-1 was absent in all tissue specimens. There was no correlation of PD-L1 or CD8 expression with disease state (primary versus metastatic) or patient survival.MethodsA comprehensive PNST tissue microarray was created from 141 surgical specimens including primary, recurrent, and metastatic MPNST (n=53), neurofibromas (n=57), schwannoma (n=11), and normal nerve (n=20). Cores were stained in triplicate for PD-L1, PD-1, and CD8, and expression compared between tumor types. These data were then examined for survival correlates in 35 patients with primary MPNST.ConclusionsMPNST is characterized by low PD-L1 and absent PD-1 expression with significant CD8+ TIL presence. MPNST immune microenvironment does not correlate with patient outcome

Human Milk Products in the National Health Service: A Cross-sectional Survey of Use and Industry Contact across England's Trusts

OBJECTIVES: Commentators and professional organisations note that an expanding market in human milk-based products (HMBPs) could reduce breastfeeding, compromising maternal and infant health, and undermine public milk bank donations. We investigate whether English NHS trusts purchased these products and whether HMBP companies have marketed to them. DESIGN: Freedom of Information (FOI) requests asking: (1) whether trusts obtained human milk; (2) if so, how; and (3) whether HMBP companies had approached them. We analysed trusts' responses qualitatively. In 2023, an FOI request to the Food Standards Authority (FSA) following a product recall. SETTING: England. PARTICIPANTS: One hundred and ninety-four NHS trusts, the FSA. MAIN OUTCOME MEASURES: Obtaining human milk, approaches by companies, and trust responses to approaches. RESULTS: One hundred and seventy-six trusts responded, 102 reporting human milk from milk banks. No trusts reported purchasing from companies in 2022. In 2023, the FSA confirmed six English hospitals used HMBPs from one company; an FOI for trusts' names was refused on law enforcement grounds. Two trusts reported participating in clinical trials funded by companies. Twenty-one reported approaches, using several strategies, including uninvited ward visits. Trusts rejected marketing based on guidance from: (1) trust dieticians or physicians; (2) regional regulatory bodies; (3) professional bodies; and (4) perceived application of an International Code on breastfeeding. CONCLUSIONS: Companies market to trusts, adopting methods previously used by the formula industry. Trusts express confusion over whether this infringes agreements designed to promote breastfeeding. We encourage clarification and guidance for professionals and trusts to ensure safety, infant and maternal health, and protect public provision

Emergency supply of prescription-only medicines to patients by community pharmacists: a mixed methods evaluation incorporating patient, pharmacist and GP perspectives

Objective To evaluate and inform emergency supply of prescription-only medicines by community pharmacists (CPs), including how the service could form an integral component of established healthcare provision to maximise adherence. Design Mixed methods. 4 phases: prospective audit of emergency supply requests for prescribed medicines (October–November 2012 and April 2013); interviews with CPs (February–April 2013); follow-up interviews with patients (April–May 2013); interactive feedback sessions with general practice teams (October–November 2013). Setting 22 community pharmacies and 6 general practices in Northwest England. Participants 27 CPs with experience of dealing with requests for emergency supplies; 25 patients who received an emergency supply of a prescribed medicine; 58 staff at 6 general practices. Results Clinical audit in 22 pharmacies over two 4-week periods reported that 526 medicines were requested by 450 patients. Requests peaked over a bank holiday and around weekends. A significant number of supplies were made during practice opening hours. Most requests were for older patients and for medicines used in long-term conditions. Difficulty in renewing repeat medication (forgetting to order, or prescription delays) was the major reason for requests. The majority of medicines were ‘loaned’ in advance of a National Health Service (NHS) prescription. Interviews with CPs and patients indicated that continuous supply had a positive impact on medicines adherence, removing the need to access urgent care. General practice staff were surprised and concerned by the extent of emergency supply episodes. Conclusions CPs regularly provide emergency supplies to patients who run out of their repeat medication, including during practice opening hours. This may aid adherence. There is currently no feedback loop, however, to general practice. Patient care and interprofessional communication may be better served by the introduction of a formally structured and funded NHS emergency supply service from community pharmacies, with ongoing optimisation of repeat prescribing