Utilizing self-organization systems for modeling and managing risk based on maintenance and repair in petrochemical industries

Maintenance is essential to ensure safe operation of equipment in normal conditions. Therefore, managers must identify the relative priorities and equipment maintenance requirements. Moreover, based on the results of equipment vulnerability assessments, maintenance programs can be developed and managed properly. There are different methods and techniques in the process of risk assessment and management and vulnerability of equipment. Seventy-six samples with different properties have been used in this study. Networks used in this study are self-organizing networks with constant weight, which include Kohonen networks. For this purpose, operation impact, operation flexibility, maintenance cost, impact of safety and environment and frequency parameters had been considered as input; and using this model, the risk level is calculated. Utilizing genetic algorithms, the structures of all self-organizing systems are optimized. In order to evaluate the accuracy of the model, we compare it with the fuzzy model, and the results indicate that self-organizing systems optimized with the genetic algorithm have higher ability, flexibility and accuracy than the fuzzy model in predicting risk

Antioxidant and cytotoxic properties of protein hydrolysates obtained from enzymatic hydrolysis of Klunzinger’s mullet (Liza klunzingeri) muscle

Today, consumers are looking for functional foods that promote health and prevent certain diseases in addition to provide nutritional requirements. This study aimed to evaluate the antioxidant and cytotoxic properties of Liza klunzingeri protein hydrolysates. Fish protein hydrolysates (FPHs) were prepared from L. klunzingeri muscle using enzymatic hydrolysis with papain at enzyme/substrate ratios of 1:25 and 1:50 for 45, 90 and 180 min. The antioxidant activities of the FPHs were investigated through five antioxidant assays. The cytotoxic effects on 4T1 carcinoma cell line were also evaluated. The amino acid composition and molecular weight distribution of the hydrolysate with the highest antioxidant activity were determined by HPLC. All six FPHs exhibited good scavenging activity on ABTS (IC50=0.60-0.12 mg/mL), DPPH (IC50= 3.18-2.08 mg/mL), and hydroxyl (IC50=4.13-2.07 mg/mL) radicals. They also showed moderate Fe+2 chelating capacity (IC50=2.12-12.60 mg/mL) and relatively poor ferric reducing activity (absorbance at 70 nm= 0.01-0.15, 5 mg/mL). In addition, all hydrolysates showed cytotoxic activities against the 4T1 cells (IC50=1.62-2.61 mg/mL). 94.6% of peptide in hydrolysate with the highest antioxidant activity had molecular weight less than 1,000 Da. L. klunzingeri protein hydrolysates show significant antioxidant and anticancer activities in vitro and are suggested to be used in animal studies

Demonstration of the etching cobalt oxide grown on the stainless steel as a base metal surface using F2/He dielectric barrier discharge plasma in atmospheric pressure

Metal surface cleaning or etching techniques using reactive plasma are emerging as one of the dry processing techniques for surface contaminants with high bond energy, especially for cleaning and decontamination of nuclear components and equipment. In this study, the plasma reaction due to the discharge of a dielectric barrier of a mixture of 95% helium and 5% fluorine with cobalt oxide film grown on the surface of stainless steel 304 was studied experimentally. Experimental results show that cobalt oxide becomes a powder after plasma irradiation and is easily separated from the surface of the base metal. The optimal plasma generating conditions of the dielectric barrier discharge (DBD) used in this experimental study were obtained at atmospheric pressure, voltage 4.5 kV, and frequency 25 kHz with a etching rate of 10.875 {\mu}mol/min. The samples were analyzed before and after plasma irradiation, using Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and the purification rate was performed using a sequential weighting of the samples with scales 10^(-4) grams accurately obtained. The results show the ability of this method to effectively remove the surface contamination of cobalt from the surface of stainless steel 304

Prediction of Concrete Compressive Strength by Evolutionary Artificial Neural Networks

Compressive strength of concrete has been predicted using evolutionary artificial neural networks (EANNs) as a combination of artificial neural network (ANN) and evolutionary search procedures, such as genetic algorithms (GA). In this paper for purpose of constructing models samples of cylindrical concrete parts with different characteristics have been used with 173 experimental data patterns. Water-cement ratio, maximum sand size, amount of gravel, cement, 3/4 sand, 3/8 sand, and coefficient of soft sand parameters were considered as inputs; and using the ANN models, the compressive strength of concrete is calculated. Moreover, using GA, the number of layers and nodes and weights are optimized in ANN models. In order to evaluate the accuracy of the model, the optimized ANN model is compared with the multiple linear regression (MLR) model. The results of simulation verify that the recommended ANN model enjoys more flexibility, capability, and accuracy in predicting the compressive strength of concrete

Generation and Reactions of a Benzodehydrotropylium Ion-Co2(CO)6 Complex

A series of 7-methylenedehydrobenzo[7]annulen-5-ol hexacarbonyldicobalt complexes were generated by Hosomi-Sakurai reactions of allylsilanes containing o-alkynylarylaldehyde-Co2(CO)6 complexes. One of cyclization products was converted into its corresponding dihydrobenzo[7]annulen-7-ol hexacarbonyldicobalt complex, an immediate precursor to a benzodehydrotropylium-Co2(CO)6. The cation was generated in situ and reacted with four nucleophiles, and its aromatic stabilization determined by computational methods

Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo

Introduction Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease. Objectives We explored the role of amino acids in vitiligo using targeted metabolomics. Methods The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precisely determined. Next, the concentrations of the amino acids and the molar ratios were calculated in 31 patients and 34 healthy individuals. Results The differential concentrations of amino acids were analyzed and eight amino acids, i.e., cysteine, arginine, lysine, ornithine, proline, glutamic acid, histidine, and glycine were observed differentially. The ratios of cysteine, glutamic acid, and proline increased significantly in Vitiligo patients, whereas arginine, lysine, ornithine, glycine, and histidine decreased significantly compared to healthy individuals. Considering the percentage of skin area, we also showed that glutamic acid significantly has a higher amount in patients with less than 25% involvement compared to others. Finally, cysteine and lysine are considered promising candidates for diagnosing and developing the disorder with high accuracy (0.96). Conclusion The findings are consistent with the previously illustrated mechanism of Vitiligo, such as production deficiency in melanin and an increase in immune activity and oxidative stress. Furthermore, new evidence was provided by using amino acids profile toward the pathogenicity of the disorder.Peer reviewe

Antioxidant and cytotoxic properties of protein hydrolysates obtained from enzymatic hydrolysis of Klunzinger’s mullet (Liza klunzingeri) muscle

Today, consumers are looking for functional foods that promote health and prevent certain diseases in addition to provide nutritional requirements. This study aimed to evaluate the antioxidant and cytotoxic properties of Liza klunzingeri protein hydrolysates. Fish protein hydrolysates (FPHs) were prepared from L. klunzingeri muscle using enzymatic hydrolysis with papain at enzyme/substrate ratios of 1:25 and 1:50 for 45, 90 and 180 min. The antioxidant activities of the FPHs were investigated through five antioxidant assays. The cytotoxic effects on 4T1 carcinoma cell line were also evaluated. The amino acid composition and molecular weight distribution of the hydrolysate with the highest antioxidant activity were determined by HPLC. All six FPHs exhibited good scavenging activity on ABTS (IC50=0.60-0.12 mg/mL), DPPH (IC50= 3.18-2.08 mg/mL), and hydroxyl (IC50=4.13-2.07 mg/mL) radicals. They also showed moderate Fe+2 chelating capacity (IC50=2.12-12.60 mg/mL) and relatively poor ferric reducing activity (absorbance at 70 nm= 0.01-0.15, 5 mg/mL). In addition, all hydrolysates showed cytotoxic activities against the 4T1 cells (IC50=1.62-2.61 mg/mL). 94.6% of peptide in hydrolysate with the highest antioxidant activity had molecular weight less than 1,000 Da. L. klunzingeri protein hydrolysates show significant antioxidant and anticancer activities in vitro and are suggested to be used in animal studies. Keywords: Antioxidant activity; Cytotoxic effect; Protein hydrolysate; Liza klunzinger

Applying the DeLone and McLean Model for Assessment of Golestan Academic System: A Case Study

Objective: In this paper, we have tried to evaluate the quality of the “Golestan” system by relying on the conceptual model of Delon and Maclean (2003). Methods: To do this, we have used the Model of Pavkovic, Gasper, and Jadrick (2021), which includes the developed form of the Delon and Maclean model along with the standard formative questionnaire, consists of 5 dimensions and 40 subscales, and organized in the continuum range of 1 to 10. The present study was the educational support staff and students of Tehran public universities who were sampled by multi-stage cluster sampling method and Shahid Beheshti, Shahed, and Allameh Tabataba'i universities were selected as samples and sample sizes of 151 and 302 were determined by Cochran formula for educational support staff and students of the mentioned universities, which finally 128 and 264 employees and students responded to the questionnaire, respectively. Results: Some important findings were obtained from this study. First, the “system performance quality” in all subscales was lower than average, and “information quality” was higher than average. Second, the components of “proportionality to the need”, “the time of registration of inputs”, “alternative access possibility”, “the confidentiality of access”, and “the accuracy of the information” were identified as most important. Third, the evaluation of students about “information quality”, “quality of system performance”, and “service quality” of the Golestan system was more desirable and positive than the staff's point of view. Fourth, only the dimension of “system performance quality” was effective on “system use”, and the rest of the dimensions namely “quality of information” and "quality of information" had no significant effect on the use of the system. Finally, the dimension of “system performance quality” had the most significant indirect effect on user satisfaction. Conclusions: The quality of system performance and its ingredients such as being adjusted to needs, reliable accessibility, optimum response time, optimum input time, error-free performance, and multiple options for getting access are the most important factors of quality for the Golestan system

The protective effect of Liza klunzingeri protein hydrolysate on carbon tetrachloride-induced oxidative stress and toxicity in male rats

Objective(s): Today, consumers are looking for food products providing health benefits in addition to meeting the basic nutritional needs of the body. This study aimed to evaluate the antioxidant and cytotoxic effects of Liza klunzingeri protein hydrolysate both in vivo and in vitro. Materials and Methods: Fish protein hydrolysate (FPH) was prepared using enzymatic hydrolysis with papain. In vitro antioxidant activity was assessed using five different antioxidant assays. The cytotoxic effect on 4T1 cell line was evaluated using the MTT assay. The distribution of the molecular weight of FPH was measured using HPLC. In the in vivo study, CCl4-exposed Wistar rats were orally treated with FPH (150, 300, and 600 mg/kg) or gallic acid (50 mg/kg) for 28 consecutive days. Results: Enzymatic hydrolysis gave hydrolysate rich in low molecular weight peptides (<1000 Da) with strong free radicals (ABTS, DPPH, and OH) scavenging activity and cytotoxicity. Treatment of CCl4-exposed rats with all doses of FPH significantly lowered serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). FPH at doses of 300 and 600 mg/kg significantly decreased lipid peroxidation and improved total antioxidant capacity in serum, liver, and kidney of the CCl4 exposed rats. All doses of L.klunzingeri protein hydrolysate reduced CCl4-induced nitric oxide production of the kidney. Liver histopathological damage caused by CCl4 also ameliorated with all doses of FPH. Conclusion: L. klunzingeri protein hydrolysate can be considered as a functional food to alleviate oxidative stress. Keywords Author Keywords:Antioxidant activity; Cytotoxicity; Liza klunzingeri; Oxidative stress; Protein hydrolysat

Kappa-carrageenan as an effective cryoprotectant on water mobility and functional properties of grass carp myofibrillar protein gel during frozen storage

The effect of kappa-carrageenan oligosaccharides was analyzed on the gelling abilities of grass carp myofibrillar proteins (MP) during 60 days frozen storage. Four gel treatments were prepared: control without additives (C), a positive control with sucrose: sorbitol (PC), and two batches with 1 and 2% of kappa-carrageenan (KC). All MP gels showed a significant decline in the functional and structural properties. Water holding capacity (WHC) and textural properties of control MP gel was significantly reduced due to oxidative changes, whereas weak cross-linking between amino acid molecules and denaturation of myosin observed. In contrast, PC and KC showed a significant control on the reduction of functional properties due to the enhanced inter/intra-molecular interactions and less formation of ice crystals. Addition of KC (2%) significantly restricted the decline in WHC from 95.45 to 75.47%, which is well associated with high hydrogen proton density. Besides that, low field nuclear magnetic resonance (LF-NMR) analysis exhibited a restricted increase in T22 relaxation time in samples added with KC (2%). Overall, MP gel with KC (2%) proved to be an effective alternative in comparison with PC and could be efficient in the production and commercialization of fish and other seafood products.National Natural Science Foundation of China | Ref. 31972104National Natural Science Foundation of China | Ref. 51809224National Natural Science Foundation of China | Ref. 3147169