S-band electron linac with beam energy of 30…100 MeV

The S-band electron linac has been designed at NSC KIPT to cover an energy range from 30 to 100 MeV. The linac consists of the injector based on evanescent oscillations and the two four-meter long piecewise homogeneous accelerating sections. Each section is supplied with RF power from the KIU-12AM klystron. Variation of mean energy of the beam over a wide range is produced by placing bunches out of the wave crest in the second accelerating section. The report presents layout of the linac as well as simulation results of self-consistent particle dynamics in the linac and its present status.Лінійний прискорювач електронів 10 см - діапазону було розроблено в ННЦ ХФТІ з метою перекрити діапазон енергій 30…100 MeВ. Прискорювач складається з інжектора, основаного на коливаннях, що не розповсюджуються, і двох шматково-однорідних чотириметрових прискорювальних секцій. Кожна секція забезпечується НВЧ-потужністю від клістрона KІУ-12AM. Зміна середньої енергії пучка в широких межах забезпечується прискоренням згустків не на гребені хвилі в другій прискорювальній секції. Представлено структурну схему прискорювача, результати моделювання динаміки частинок в прискорювачі і його поточний стан.Линейный ускоритель электронов 10 см - диапазона был разработан в ННЦ ХФТИ с целью перекрытия диапазона энергий 30…100 MэВ. Ускоритель состоит из инжектора, основанного на не распространяющихся колебаниях и двух кусочно-однородных четырехметровых ускоряющих секций. Каждая секция питается СВЧ-мощностью от клистрона KИУ-12AM. Изменение средней энергии пучка в широких пределах обеспечивается ускорением сгустков не на гребне волны во второй ускоряющей секции. Представлены структурная схема ускорителя, результаты моделирования динамики частиц в ускорителе и его текущее состояние

Electron linacs in NSC KIPT: R&D and application

A review is given about electron linacs of NSC KIPT and their some applications for research of radiation effects in reactor materials, channeling, plasma-beam interactions, geology (gamma-activation analysis of ore samples), as well as sterilization of single-use medical products, modification of polymers and semiconductors, isotope production for nuclear medicine etc

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Antibacterial activity profile of miramistin in in vitro and in vivo models

© 2020 Background: Miramistin is a widely used antiseptic, disinfectant and preservative, and one of the most popular antimicrobial agents on pharmaceutical market of the Russian Federation (http://www.dsm.ru/en/news/385/). However, there is a lack of reported systematic data on antibacterial efficacy of this agent obtained in accordance with the international standards. Aim: This paper represents a systematic study of antibacterial properties of miramistin. Another objective of this work is to evaluate and compare the exploratory performance of in vitro and in vivo protocols of antiseptics’ efficacy testing using miramistin as the reference antiseptic. Methods: Antibacterial activity of 0.1% and 0.2% aqueous solutions of miramistin against two museum strains of S. aureus (ATCC 209p) and E. coli (CDC F-50) was studied. Three standard in vitro laboratory tests (microdilution test, suspension test, and metal surface test), and one in vivo test (on rat's skin) were used. The study was conducted in accordance with the international regulatory documents. Results: Miramistin showed high bactericidal activity against the studied bacterial pathogens in the standard in vitro tests. Thus, in the microdilution test it showed expressed activity against S. aureus (MIC 8 μg/ml, MBC 16 μg/ml) and E. coli (MIC 32 μg/ml, MBC 128 μg/ml). In the suspension test, miramistin decreased the amount of colony forming units by at least 6 log10 units for S. aureus, and by at least 4.5 log10 units for E. coli. Transition to the metal surface test led to significant decrease of antibacterial activity by 1–3 log10 units as compared to the suspension test. Further dramatic reduction of antiseptic activity (by 3–4 log10 units) was observed in in vivo rat skin test. Addition of a protein contaminant (bovine serum albumin) led to a general decrease in the effectiveness of miramistin against the test pathogens (typically, by 1–2 log10 units). An interesting effect of exposure time-dependent reversal of miramistin's specificity to the studied Gram-positive S. aureus and the Gram-negative E. coli organisms was observed in the metal surface test. Conclusions: The results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics’ efficacy testing and surface disinfection procedures

The expediency of fiber-optical communication line used in different schemes of reception tract of the radio monitoring complex

В статье рассмотрены все варианты схем построения широкополосного и узкополосного приемного тракта для передачи СВЧ сигналов в комплексах радиомониторинга. Представлены характеристики приемного тракта, как с использование волоконн-оптической линии связи, так и СВЧ кабеля в различных его частях. Отмечены особенности, достоинства и недостатки применения волоконно-оптической линии связи. Проведено сравнение характеристик исследуемых частей приемных трактов с зарубежными аналогами. Представлены результаты экспериментальных исследований и теоретических расчетов. In the article the all variants of broadband and narrowband receiving tract design schemes for microwave signal transmission in radio monitoring complexes are considered. The characteristics of receiving tract with use of fiber-optic communication line or microwave cable in its various parts are presented. The features, advantages and disadvantages of using fiber-optic communication lines are marked. The comparison of the investigation characteristics of receiving tract parts with foreign analogues are performed. The results of experimental research and theoretical calculations are presented

Method of assessment the degree of reliability of the pulse wave image in the rapid diagnosis of the human condition

В статье рассмотрена проблема повышения достоверности результатов диагностики состояния человека пульсоксиметром. Предложена новая методика оценки достоверности результатов измерения параметров пульсовой волны и метод настройки оптической части пульсоксиметра. Разработанный нами метод и методика позволяют сделать несущественным влияние ряда погрешностей на результаты измерений. Представлены экспериментальных данные о исследованиях состояния различных людей. This article describes the errors that occur in the diagnosis of human by pulse oximeter. The main causes of artifacts that distort the shape of the pulse wave are determined. Methods for their detection and elimination are proposed. Results of a research of people of different age are presented

Novel bis-ammonium salts of pyridoxine: Synthesis and antimicrobial properties

© 2020 by the authors. A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum inhibitory concentration (MIC) 0.25–16 µg/mL) comparable or superior than miramistin, benzalkonium chloride, and chlorhexidine. A strong correlation between the lipophilicity and antibacterial activity was found. The most active compounds had logP values in the range of 1–3, while compounds with logP > 6 and logP < 0 were almost inactive. All active compounds demonstrated cytotoxicity comparable with miramistin and chlorhexidine on HEK-293 cells and were three-fold less toxic when compared to benzalkonium chloride. The antibacterial activity of leading compound 5c12 on biofilm-embedded Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli or Pseudomonas aeruginosa was comparable or even higher than that of the benzalkonium chloride. In vivo 5c12 was considerably less toxic (LD50 1705 mg/kg) than benzalkonium chloride, miramistine, and chlorhexidine at oral administration on CD-1 mice. An aqueous solution of 5c12 (0.2%) was shown to be comparable to reference drugs efficiency on the rat’s skin model. The molecular target of 5c12 seems to be a cellular membrane as other quaternary ammonium salts. The obtained results make the described quaternary bis-ammonium pyridoxine derivatives promising and lead molecules in the development of the new antiseptics with a broad spectrum of antimicrobial activity

Brain–lung–thyroid syndrome: Literature review and series of clinical observations

Brain–lung–thyroid syndrome (BLTS) is a rare genetic disease associated with mutations in the NKX2.1 gene encoding thyroid transcription factor 1. The most common manifestations of this syndrome are benign hereditary chorea, hypothyroidism and respiratory distress syndrome, however, mutations in the NKX2.1 gene can also cause other pathologies of nervous, respiratory systems and thyroid gland. The article describes 4 patients with mutations in the NKX2.1 gene observed by authors. Based on the analysis of the observations of 168 patients with BLTS presented in the world literature from 1998 to 2019, current information on the genetics, pathogenesis, clinical X-ray manifestations, outcomes and treatment of the syndrome are summarized. © 2019, Pediatria Ltd. All rights reserved