Forecast model for the evaluation of economic resources employed in the health care of patients with HIV infection

BACKGROUND AND AIMS: The total health care cost for human immunodeficiency virus (HIV) patients has constantly grown in recent years. To date, there is no information about how this trend will behave over the next few years. The aim of the present study is to define a pharmacoeconomic model for the forecast of the costs of a group of chronically treated patients followed over the period 2004-2009.; METHODS: A pharmacoeconomics model was built to describe the probability of transition among different health states and to modify the therapy over time. A Markov model was applied to evaluate the temporal evolution of the average cost. The health care resources exploited during hospitalization were analyzed by using an "activity-based costing" method.; RESULTS: The Markov model showed that the mean total cost, after an initial increase, tended to remain stable. A total of 20 clinical records were examined. The average daily cost for each patient was EUR 484.42, with a cost for admission of EUR 6781.88.; CONCLUSION: The treatment of HIV infection in compliance with the guidelines is also effective from the payer perspective, as it allows a good health condition to be maintained and reduces the need and the costs of hospitalizations

Impact of High Neutrophil-to-Lymphocyte Ratio on Survival in Hospitalized Cancer Patients With COVID-19

Neutrophil-to-lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID-19 patients. Our study aimed to evaluate the association between NLR at COVID-19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR \u3e 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74-10.84) compared to patients with NLR \u3c 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32-6.36). Furthermore, on multivariable analysis, NLR \u3e 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID-19, an NLR \u3e 8.3 is associated with an increased risk of death

Geographic Patterns of Genome Admixture in Latin American Mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

NSSAM 2 - Nuovi sentieri di sviluppo nell'Appennino Marchigiano 2

supporto al processo di ricostruzione delle aree marchigiane danneggiate dal sism

Impacto urbano-territorial de la actuación del sector privado (mercado) en el Área Metropolitana Santa Fe–Paraná

El presente trabajo pretende dar continuidad a las indagaciones acerca del impacto urbano territorial de la actuación de las Organizaciones de la Sociedad Civil (en adelante, OSCs) que se realizaron en el proyecto homónimo en el Área Metropolitana Santa Fe – Paraná (en adelante, AMSFP) y desarrolladas entre los años 2009 y 2012, en el marco del PACT Taller de Estudios Metropolitanos (financiado por la convocatoria CAI+D 2009 de la Secretaría de Ciencia y Técnica de la Universidad Nacional del Litoral). La hipótesis central de ambos trabajos se basa en el supuesto de que el Estado ha concedido cierto protagonismo como principal promotor de las transformaciones territoriales en el AMSFP en las últimas dos décadas del siglo XX y la primera del siglo XXI. Del mismo modo que en el trabajo inicial se hizo foco en el grado de impacto que las organizaciones del tercer sector han tenido en la configuración del territorio, en esta oportunidad se analiza dicho impacto pero desde las actuaciones del sector privado (mercado). Como objetivo general, se busca contribuir al conocimiento de los procesos de transformación del AMSFP y a la generación y difusión de información urbanística precisa sobre el área, principalmente la referida a aquellos (procesos) que evidencian impactos en el territorio y han sido protagonizados por el tercer sector y el mercado inmobiliario. Desde este lugar se pretende contribuir en la construcción de información consistente, que permita mejorar las condiciones en que se desarrollan los procesos de toma de decisiones, tanto sea en el ámbito público como privado. Se espera incidir favorablemente en la elaboración e implementación de políticas públicas de calidad relacionadas con las problemáticas del área. Como cierre, se espera poder interpretar prospectivamente el AMSFP, identificando aquellos posibles escenarios futuros que podrán presentarse a partir de la implementación de políticas públicas y acciones privadas articuladas que contribuyan a un desarrollo territorial equilibrado, ordenado y sostenible.Fil: Rodriguez, Miguel. Universidad Nacional del Litoral. Facultad de Arquitectura, Diseño y Urbanismo; ArgentinaFil: Costa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Arquitectura, Diseño y Urbanismo; ArgentinaFil: Nicolini, Andrés. Universidad Nacional del Litoral. Facultad de Arquitectura, Diseño y Urbanismo; ArgentinaFil: Mosso, Emilia Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Arquitectura, Diseño y Urbanismo; Argentin

Orientamento in itinere e azioni per il job placement all'Universit\ue0 di Macerata

Sono illustrate alcune buone pratiche di accompagnamento di studenti universitari al mondo del lavoro, utilizzando una prospettiva di longlife learnin