Lutein-fortified Infant Formula Fed to Healthy Term Infants: Evaluation of Growth Effects and Safety

Background/Objectives: Breast milk contains lutein derived from the mother\u27s diet. This carotenoid is currently not added to infant formula, which has a small and variable lutein content from innate ingredients. This study was conducted to compare the growth of infants fed lutein-fortified infant formula with that of infants fed infant formula without lutein fortification. Subjects/Methods: This 16-week study was prospective, randomized, controlled, and double-blind with parallel groups of healthy term infants fed either control formula (Wyeth S-26 Gold, designated as Gold) or experimental formula (Wyeth S-26 Gold fortified with lutein at 200 mcg/l, designated as Gold + Lutein). Two hundred thirty-two (232) infants ≤ 14 days postnatal age were randomized and 220 (94.8%) completed the study. Weight (g), head circumference (cm), and length (cm) were measured at Weeks 4, 8, 12, and 16. The primary endpoint was weight gain (g/day) from baseline to Week 16. Safety was assessed through monitoring of study events (SEs) throughout the study and evaluation of selected blood chemistry tests performed at Week 16. Results: Infants in both treatment groups demonstrated appropriate growth. No differences between treatment groups were found in any of the measures of growth at any of the measurement time points. Both study formulas were well tolerated. The mean values of all measured blood chemistry parameters fell within the modified normal ranges for infants, and the values for both groups for any measured parameter were similar. Conclusions: Infants fed lutein-fortified S-26 Gold demonstrated growth equivalent to that of infants fed unfortified lutein formula

Measuring Winds From Space to Reduce the Uncertainty in the Southern Ocean Carbon Fluxes: Science Requirements and Proposed Mission

Strong winds in Southern Ocean storms drive air-sea carbon and heat fluxes. These fluxes are integral to the global climate system and the wind speeds that drive them are increasing. The current scatterometer constellation measuring vector winds remotely undersamples these storms and the higher winds within them, leading to potentially large biases in Southern Ocean wind reanalyses and the fluxes that derive from them. This observing system design study addresses these issues in two ways. First, we describe an addition to the scatterometer constellation, called Southern Ocean Storms -- Zephyr, to increase the frequency of independent observations, better constraining high winds. Second, we show that potential reanalysis wind biases over the Southern Ocean lead to uncertainty over the sign of the net winter carbon flux. More frequent independent observations per day will capture these higher winds and reduce the uncertainty in estimates of the global carbon and heat budgets

The Lesser Known Challenge of Climate Change: Thermal Variance and Sex-Reversal in Vertebrates with Temperature-Dependent Sex Determination

Climate change is expected to disrupt biological systems. Particularly susceptible are species with temperature-dependent sex determination (TSD), as in many reptiles. While the potentially devastating effect of rising mean temperatures on sex ratios in TSD species is appreciated, the consequences of increased thermal variance predicted to accompany climate change remain obscure. Surprisingly, no study has tested if the effect of thermal variance around high-temperatures (which are particularly relevant given climate change predictions) has the same or opposite effects as around lower temperatures. Here we show that sex ratios of the painted turtle (Chrysemys picta) were reversed as fluctuations increased around low and high unisexual mean-temperatures. Unexpectedly, the developmental and sexual responses around female-producing temperatures were decoupled in a more complex manner than around male-producing values. Our novel observations are not fully explained by existing ecological models of development and sex determination, and provide strong evidence that thermal fluctuations are critical for shaping the biological outcomes of climate change

Operation STEM fatale – how an equity, diversity and inclusion initiative has brought us to reflect on the current challenges in cell biology and science as a whole

From a simple thought to a multicellular movemen

Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety

<p>Abstract</p> <p>Background/Objectives</p> <p>Breast milk contains lutein derived from the mother's diet. This carotenoid is currently not added to infant formula, which has a small and variable lutein content from innate ingredients. This study was conducted to compare the growth of infants fed lutein-fortified infant formula with that of infants fed infant formula without lutein fortification.</p> <p>Subjects/Methods</p> <p>This 16-week study was prospective, randomized, controlled, and double-blind with parallel groups of healthy term infants fed either control formula (Wyeth S-26 Gold, designated as Gold) or experimental formula (Wyeth S-26 Gold fortified with lutein at 200 mcg/l, designated as Gold + Lutein). Two hundred thirty-two (232) infants ≤ 14 days postnatal age were randomized and 220 (94.8%) completed the study. Weight (g), head circumference (cm), and length (cm) were measured at Weeks 4, 8, 12, and 16. The primary endpoint was weight gain (g/day) from baseline to Week 16. Safety was assessed through monitoring of study events (SEs) throughout the study and evaluation of selected blood chemistry tests performed at Week 16.</p> <p>Results</p> <p>Infants in both treatment groups demonstrated appropriate growth. No differences between treatment groups were found in any of the measures of growth at any of the measurement time points. Both study formulas were well tolerated. The mean values of all measured blood chemistry parameters fell within the modified normal ranges for infants, and the values for both groups for any measured parameter were similar.</p> <p>Conclusions</p> <p>Infants fed lutein-fortified S-26 Gold demonstrated growth equivalent to that of infants fed unfortified lutein formula.</p

NATIONAL STATEMENT OF SCIENCE INVESTMENT DRAFT: Response from Rutherford Discovery Fellowship recipients (2010-2013)

<p>This is a joint response written and co-signed by 97.5% of New Zealand’s Rutherford Discovery Fellows. We are a group of internationally recognised early- to mid-career researchers who have been selected for our innovative approaches to research across the sciences and the humanities. We work in diverse fields, spanning physical, engineering, information and communications technology, medical, molecular and environmental research through to social sciences, law and the humanities. We are based across a wide cross-section of New Zealand’s Universities and Crown Research Institutes (CRIs), and are engaged in basic, applied and near-to-market research. All of us have directly benefitted from the investments and changes that the Government has been making to the Science sector. As a result of the Rutherford Discovery Fellowship, we have chosen to return to, or to stay in, New Zealand.</p> <p> </p