Improving Class Pace for Deaf and Hard-of-Hearing Students

Following multimedia lectures in mainstream classrooms in university education is challenging for deaf and hard-of-hearing (DHH) students even when they are provided accommodations to best address their individual needs. Due to multiple visual sources of information (teacher, slides, interpreter, blackboard), these students struggle to divide their attention among several simultaneous sources of input, which may result in their missing important parts of the lecture content; as a result, DHH students’ access to information can be limited in comparison to that of their hearing peers, and so their academic achievements may be impacted. This paper introduces SlidePacer, a tool aimed at improving coordination between the instructor’s speech, the sign language interpretation of the lecture and the slide projection change. The goal of this software is to prevent DHH students’ loss of information by promoting an adequate pace of the lecture, which can contribute to their learning and academic achievements. We conclude with discussion of future work

Imported Haycocknema perplexum Infection, United States

We report an imported case of myositis caused by a rare parasite, Haycocknema perplexum, in Australia in a 37-year-old man who had progressive facial, axial, and limb weakness, dysphagia, dysphonia, increased levels of creatine kinase and hepatic aminotransferases, and peripheral eosinophilia for 8 years. He was given extended, high-dose albendazole. © 2022 Centers for Disease Control and Prevention (CDC). All rights reserved

Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles

The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing their number as well as searching for means to replace them in experimental studies are constant objectives in this area. Due to its non-invasive character in vivo imaging supports these efforts by enabling repeated longitudinal assessments in each animal which serves as its own control, thereby enabling to reduce considerably the animal utilization in the experiments. The repetitive monitoring of pathology progression and the effects of therapy becomes feasible by assessment of quantitative biomarkers. Moreover, imaging has translational prospects by facilitating the comparison of studies performed in small rodents and humans. Also, learnings from the clinic may be potentially back-translated to preclinical settings and therefore contribute to refining animal investigations. By concentrating on activities around the application of magnetic resonance imaging (MRI) and ultrasound elastography to small rodent models of disease, we aim to illustrate how in vivo imaging contributes primarily to reduction and refinement in the context of pharmacological research

Longer-term oral antiplatelet use in stable post-myocardial infarction patients: Insights from the long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease (TIGRIS) observational study.

OBJECTIVE: To describe contemporary patient characteristics and treatment patterns, including antithrombotic management, of post-myocardial infarction (MI) stable coronary artery disease (CAD) patients at high atherothrombotic risk from different geographical regions. METHODS: Patients ≥50years with prior MI 1-3years ago and ≥1 risk factor (age ≥65years, diabetes, 2nd prior MI >1yr ago, multivessel CAD, creatinine clearance 15-1year was highest (39%) in Asia-Pacific and lowest (12%) in Europe. CONCLUSIONS: Despite guideline recommendations, 1 in 4 post-MI patients did not receive DAPT for ~1year. In contrast to guideline recommendations supporting newer ADPris, clopidogrel was mainly prescribed. Prior to recent RCT data supporting DAPT >1year post-MI/PCI, >1 in 4 patients have continued on DAPT, though with substantial international variability

Les controverses sociotechniques au prisme du Parlement

Le Parlement constitue un espace privilégié pour analyser le déploiement des controverses sociotechniques : non parce qu’il aurait la faculté de les résoudre, notamment via l’OPECST, mais parce qu’il offre de multiples occasions et modalités d’expression et de traitement de ces controverses en son sein. Espace hétérogène et poreux, il participe d’une nouvelle gouvernance des risques, plus soucieuse de leur stabilisation que de leur réduction définitive.The French Parliament offers an ideal place to analyze the unfolding of sociotechnical controversies. Not that it has any capacity to actually resolve these, including its office of science and technology; but rather because it offers a plurality of opportunities for controversies to play out within its two chambers. As a heterogeneous and porous institution, it takes part in a newly formed risk governance that aims to manage rather than definitely solve risk issues

ArteFill® Permanent Injectable for Soft Tissue Augmentation: I. Mechanism of Action and Injection Techniques

After more than 25 years of research and development, in October 2006 ArteFill® became the first and only permanent injectable wrinkle filler to receive FDA approval. ArteFill is a third-generation polymeric microsphere-based filler, following its predecessor Artecoll®, which was marketed outside the United States between 1994 and 2006. ArteFill is approved for the correction of nasolabial folds and has been used in over 15,000 patients since its U.S. market introduction in February 2007. No serious side effects have been reported to date according to the FDA’s MAUDE reporting database. ArteFill consists of polymethylmethacrylate (PMMA) microspheres (20% by volume), 30–50 μm in diameter, suspended in 3.5% bovine collagen solution (80% by volume) and 0.3% lidocaine. The collagen carrier is absorbed within 1 month after injection and completely replaced by the patient’s own connective tissue within 3 months. Each cc of ArteFill contains approximately six million microspheres and histological studies have shown that long-term wrinkle correction consists of 80% of the patient’s own connective tissue and 20% microspheres. The standard injection technique is subdermal tunneling that delivers a strand of ArteFill at the dermal–subdermal junction. This strand beneath a wrinkle or fold acts like a support structure that protects against further wrinkling and allows the diminished thickness of the dermis to recover to its original thickness

Mathematical model for identifying and quantifying the overall environmental cost

The paper deals with the environmental costs (EC) in the electrical equipment industry by using environmental accounting as a strategic instrument for controlling the economic entity (EE). The novelty of the study consists of integrating a mathematical model in environmental management accounting (EMA), starting from the identification of the types of waste generated by the production flow and the interaction between the production activity and the environment, which results in determining the EC per entity. The research also analyzes the dependence between the resulting waste and the volume of production by categories. The usefulness of determining these dependencies leads to the identification of the product categories with a significant influence on the EC. The study is useful for developing an environmentally sustainable accounting system within entities in the electrical equipment industry because based on the mathematical model, products that generate large quantities of waste can be identified, allowing the outline of managerial strategies to reviewing production technologies, in order to optimize the products and reduce the quantities of waste generated

Off-line evaluation of mobile-centric indoor positioning systems: the experiences from the 2017 IPIN competition

The development of indoor positioning solutions using smartphones is a growing activity with an enormous potential for everyday life and professional applications. The research activities on this topic concentrate on the development of new positioning solutions that are tested in specific environments under their own evaluation metrics. To explore the real positioning quality of smartphone-based solutions and their capabilities for seamlessly adapting to different scenarios, it is needed to find fair evaluation frameworks. The design of competitions using extensive pre-recorded datasets is a valid way to generate open data for comparing the different solutions created by research teams. In this paper, we discuss the details of the 2017 IPIN indoor localization competition, the different datasets created, the teams participating in the event, and the results they obtained. We compare these results with other competition-based approaches (Microsoft and Perf-loc) and on-line evaluation web sites. The lessons learned by organising these competitions and the benefits for the community are addressed along the paper. Our analysis paves the way for future developments on the standardization of evaluations and for creating a widely-adopted benchmark strategy for researchers and companies in the field.We would like to thank Topcon Corporation for sponsoring the competition track with an award for the winning team. We are also grateful to Francesco Potorti, Sangjoon Park, Hideo Makino, Nobuo Kawaguchi, Takeshi Kurata and Jesus Urena for their invaluable help in organizing and promoting the IPIN competition and conference. Many thanks to Raul Montoliu, Emilio Sansano, Marina Granel and Luis Alisandra for collecting the databases in the UJITI building. Parts of this work were carried out with the financial support received from projects and grants: REPNIN network (TEC2015-71426-REDT), LORIS (TIN2012-38080-C04-04), TARSIUS (TIN2015-71564-C4-2-R (MINECO/FEDER)), SmartLoc (CSIC-PIE Ref. 201450E011), "Metodologias avanzadas para el diseno, desarrollo, evaluacion e integracion de algoritmos de localizacion en interiores" (TIN2015-70202-P), GEO-C (Project ID: 642332, H2020-MSCA-ITN-2014-Marie Sklodowska-Curie Action: Innovative Training Networks), and financial support from the Ministry of Science and Technology, Taiwan (106-3114-E-007-005 and 105-2221-E-155-013-MY3). The HFTS team has been supported in the frame of the German Federal Ministry of Education and Research programme "FHprofUnt2013" under contract 03FH035PB3 (Project SPIRIT). The UMinho team has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT-Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2013. G.M. Mendoza-Silva gratefully acknowledges funding from grant PREDOC/2016/55 by Universitat Jaume I.info:eu-repo/semantics/publishedVersio