Harry Partch: And on the Seventh Day Petals Fell on Petaluma

Harry Partch's tuning system is an important contribution to tuning theory, and his music is original and significant. Part One of this study presents a brief biography of Partch, a discussion of his musical aesthetics (Monophony and Corporeality), and a technical summary of his tuning system. These elements are placed in historical perspective. Part Two presents a comprehensive analysis of "And on the Seventh Day Petals Fell on Petaluma," discussing the organization of formal, textural, rhythmic, linear, and tonal elements in the thirty-four "verses" of the work. Part Two concludes by showing how large-scale structure in the work is achieved through an overlay process

Heaviness, health and happiness: a cross-sectional study of 163 066 UK Biobank participants

<b>Background</b><p></p> Obesity is known to increase the risk of many diseases and reduce overall quality of life. This study examines the relationship with self-reported health (SRH) and happiness.<p></p> <b>Methods</b> <p></p>We conducted a cross-sectional study of the 163 066 UK Biobank participants who completed the happiness rating. The association between adiposity and SRH and happiness was examined using logistic regression. SRH was defined as good (excellent, good), or poor (fair, poor). Self-reported happiness was defined as happy (extremely, very, moderately) or unhappy (moderately, very, extremely). <p></p> <b>Results</b> <p></p>Poor health was reported by 44 457 (27.3%) participants. The adjusted ORs for poor health were 3.86, 2.92, 2.60 and 6.41 for the highest, compared with lowest, deciles of Body Mass Index, waist circumference, waist to hip ratio and body fat percent, respectively. The associations were stronger in men (p<0.001). Overall, 7511 (4.6%) participants felt unhappy, and only class III obese participants were more likely to feel unhappy (adjusted OR 1.33, 95% CI 1.15 to 1.53, p<0.001) but the associations differed by sex (p<0.001). Among women, there was a significant association between unhappiness and all levels of obesity. By contrast, only class III obese men had significantly increased risk and overweight and class I obese men were less likely to be unhappy. <p></p> <b>Conclusions</b><p></p>Obesity impacts adversely on happiness as well as health, but the association with unhappiness disappeared after adjustment for self-reported health, indicating this may be mediated by health. Compared with obese men, obese women are less likely to report poor health, but more likely to feel unhappy. <p></p&gt

The first systematically identified repeating partial tidal disruption event

Tidal disruption events (TDEs) occur when a star enters the tidal radius of a supermassive black hole (SMBH). If the star only grazes the tidal radius, a fraction of the stellar mass will be accreted in a partial TDE (pTDE). The remainder can continue orbiting and may re-disrupted at pericenter, causing a repeating pTDE. pTDEs may be as or more common than full TDEs (fTDEs), yet few are known. In this work, we present the discovery of the first repeating pTDE from a systematically-selected sample, AT\,2020vdq. AT\,2020vdq was originally identified as an optically- and radio-flaring TDE. Around $3$ years after its discovery, it rebrightened dramatically and rapidly in the optical. The optical flare was remarkably fast and luminous compared to previous TDEs. It was accompanied by extremely broad (${\sim}0.1c$) optical/UV spectral features and faint X-ray emission ($L_X \sim 3\times10^{41}$\,erg\,s$^{-1}$), but no new radio-emitting component. Based on the transient optical/UV spectral features and the broadband light curve, we show that AT\,2020vdq is a repeating pTDE. We then use it to constrain TDE models; in particular, we favor a star originally in a very tight binary system that is tidally broken apart by the Hills mechanism. We also constrain the repeating pTDE rate to be $10^{-6}$ to $10^{-5}$ yr$^{-1}$ galaxy$^{-1}$, with uncertainties dominated by the unknown distribution of pTDE repeat timescales. In the Hills framework, this means the binary fraction in the galactic nucleus is of the order few percent.Comment: 24 pages, 13 figures, submitted to Ap

Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants

<b>Background</b><p></p> Previous studies on the association between adiposity and mood disorder have produced contradictory results, and few have used measurements other than body mass index (BMI). We examined the association between probable major depression and several measurements of adiposity: BMI, waist circumference (WC), waist-hip-ratio (WHR), and body fat percentage (BF%).<p></p> <b>Methods</b><p></p> We conducted a cross-sectional study using baseline data on the sub-group of UK Biobank participants who were assessed for mood disorder. Multivariate logistic regression models were used, adjusting for potential confounders including: demographic and life-style factors, comorbidity and psychotropic medication.<p></p> <b>Results</b><p></p> Of the 140,564 eligible participants, evidence of probable major depression was reported by 30,145 (21.5%). The fully adjusted odds ratios (OR) for obese participants were 1.16 (95% confidence interval (CI) 1.12, 1.20) using BMI, 1.15 (95% CI 1.11, 1.19) using WC, 1.09 (95% CI 1.05, 1.13) using WHR and 1.18 (95% CI 1.12, 1.25) using BF% (all p <0.001). There was a significant interaction between adiposity and gender (p = 0.001). Overweight women were at increased risk of depression with a dose response relationship across the overweight (25.0-29.9 kg/m2), obese I (30.0-34.9 kg/m2), II (35.0-39.9 kg/m2) and III (≥40.0 kg/m2) categories; fully adjusted ORs 1.14, 1.20, 1.29 and 1.48, respectively (all p < 0.001). In contrast, only obese III men had significantly increased risk of depression (OR 1.29, 95% CI 1.08, 1.54, p = 0.006).<p></p> <b>Conclusion</b><p></p> Adiposity was associated with probable major depression, irrespective of the measurement used. The association was stronger in women than men. Physicians managing overweight and obese women should be alert to this increased risk

The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

Abstract: Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of ADs in randomised trials is inconsistent and needs improving. Incompletely reported AD randomised trials are difficult to reproduce and are hard to interpret and synthesise. This consequently hampers their ability to inform practice as well as future research and contributes to research waste. Better transparency and adequate reporting will enable the potential benefits of ADs to be realised. This extension to the Consolidated Standards Of Reporting Trials (CONSORT) 2010 statement was developed to enhance the reporting of randomised AD clinical trials. We developed an Adaptive designs CONSORT Extension (ACE) guideline through a two-stage Delphi process with input from multidisciplinary key stakeholders in clinical trials research in the public and private sectors from 21 countries, followed by a consensus meeting. Members of the CONSORT Group were involved during the development process. The paper presents the ACE checklists for AD randomised trial reports and abstracts, as well as an explanation with examples to aid the application of the guideline. The ACE checklist comprises seven new items, nine modified items, six unchanged items for which additional explanatory text clarifies further considerations for ADs, and 20 unchanged items not requiring further explanatory text. The ACE abstract checklist has one new item, one modified item, one unchanged item with additional explanatory text for ADs, and 15 unchanged items not requiring further explanatory text. The intention is to enhance transparency and improve reporting of AD randomised trials to improve the interpretability of their results and reproducibility of their methods, results and inference. We also hope indirectly to facilitate the much-needed knowledge transfer of innovative trial designs to maximise their potential benefits. In order to encourage its wide dissemination this article is freely accessible on the BMJ and Trials journal websites.“To maximise the benefit to society, you need to not just do research but do it well” Douglas G Altma

Genomic analysis of the function of the transcription factor gata3 during development of the Mammalian inner ear

We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory cell types and developmental stages. We tested and applied a novel probabilistic method called the gamma Model for Oligonucleotide Signals to analyse hybridization signals from Affymetrix oligonucleotide arrays. Expression levels estimated by this method correlated closely (p<0.0001) across a 10-fold range with those measured by quantitative RT-PCR for a sample of 61 different genes. In an unbiased list of 26 genes whose temporal profiles clustered most closely with that of gata3 in all cell lines, 10 were linked to Insulin-like Growth Factor signalling, including the serine/threonine kinase Akt/PKB. Knock-down of gata3 in vitro was associated with a decrease in expression of genes linked to IGF-signalling, including IGF1, IGF2 and several IGF-binding proteins. It also led to a small decrease in protein levels of the serine-threonine kinase Akt2/PKB beta, a dramatic increase in Akt1/PKB alpha protein and relocation of Akt1/PKB alpha from the nucleus to the cytoplasm. The cyclin-dependent kinase inhibitor p27(kip1), a known target of PKB/Akt, simultaneously decreased. In heterozygous gata3 null mice the expression of gata3 correlated with high levels of activated Akt/PKB. This functional relationship could explain the diverse function of gata3 during development, the hearing loss associated with gata3 heterozygous null mice and the broader symptoms of human patients with Hearing-Deafness-Renal anomaly syndrome

Tidal Disruption Event Demographics with the Zwicky Transient Facility: Volumetric Rates, Luminosity Function, and Implications for the Local Black Hole Mass Function

We conduct a systematic tidal disruption event (TDE) demographics analysis using the largest sample of optically selected TDEs. A flux-limited, spectroscopically complete sample of 33 TDEs is constructed using the Zwicky Transient Facility over three years (from October 2018 to September 2021). We infer the black hole (BH) mass ($M_{\rm BH}$) with host galaxy scaling relations, showing that the sample $M_{\rm BH}$ ranges from $10^{5.1}\,M_\odot$ to $10^{8.2}\,M_\odot$. We developed a survey efficiency corrected maximum volume method to infer the rates. The rest-frame $g$-band luminosity function (LF) can be well described by a broken power-law of $\phi (L_g)\propto [(L_g / L_{\rm bk})^{0.3} + (L_g / L_{\rm bk})^{2.6}]^{-1}$, with $L_{\rm bk}=10^{43.1}\,{\rm erg\,s^{-1}}$. In the BH mass regime of $10^{5.3}\lesssim (M_{\rm BH}/M_\odot) \lesssim 10^{7.3}$, the TDE mass function follows $\phi(M_{\rm BH})\propto M_{\rm BH}^{-0.25}$, which favors a flat local BH mass function ($dn_{\rm BH}/d{\rm log}M_{\rm BH}\approx{\rm constant}$). We confirm the significant rate suppression at the high-mass end ($M_{\rm BH}\gtrsim 10^{7.5}\,M_\odot$), which is consistent with theoretical predictions considering direct capture of hydrogen-burning stars by the event horizon. At a host galaxy mass of $M_{\rm gal}\sim 10^{10}\,M_\odot$, the average optical TDE rate is $\approx 3.2\times 10^{-5}\,{\rm galaxy^{-1}\,yr^{-1}}$. We constrain the optical TDE rate to be [3.7, 7.4, and 1.6$]\times 10^{-5}\,{\rm galaxy^{-1}\,yr^{-1}}$ in galaxies with red, green, and blue colors.Comment: Replaced following peer-review process. 38 pages, 23 figures. Accepted for publication in ApJ

The Tidal Disruption Event AT2021ehb : Evidence of Relativistic Disk Reflection, and Rapid Evolution of the Disk-Corona System

© 2022. The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the Creative Commons Attribution License, to view a copy of the license, see: https://creativecommons.org/licenses/by/4.0/We present X-ray, UV, optical, and radio observations of the nearby ($\approx78$ Mpc) tidal disruption event (TDE) AT2021ehb/ZTF21aanxhjv during its first 430 days of evolution. AT2021ehb occurs in the nucleus of a galaxy hosting a $\approx 10^{7}\,M_\odot$ black hole ($M_{\rm BH}$ inferred from host galaxy scaling relations). High-cadence Swift and NICER monitoring reveals a delayed X-ray brightening. The spectrum first undergoes a gradual ${\rm soft }\rightarrow{\rm hard}$ transition and then suddenly turns soft again within 3 days at $\delta t\approx 272$ days during which the X-ray flux drops by a factor of ten. In the joint NICER+NuSTAR observation ($\delta t =264$ days, harder state), we observe a prominent non-thermal component up to 30 keV and an extremely broad emission line in the iron K band. The bolometric luminosity of AT2021ehb reaches a maximum of $6.0^{+10.4}_{-3.8}\% L_{\rm Edd}$ when the X-ray spectrum is the hardest. During the dramatic X-ray evolution, no radio emission is detected, the UV/optical luminosity stays relatively constant, and the optical spectra are featureless. We propose the following interpretations: (i) the ${\rm soft }\rightarrow{\rm hard}$ transition may be caused by the gradual formation of a magnetically dominated corona; (ii) hard X-ray photons escape from the system along solid angles with low scattering optical depth ($\sim\,$a few) whereas the UV/optical emission is likely generated by reprocessing materials with much larger column density -- the system is highly aspherical; (iii) the abrupt X-ray flux drop may be triggered by the thermal-viscous instability in the inner accretion flow leading to a much thinner disk.Peer reviewe

The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex

The histone demethylase LSD1 plays a pivotal role in cellular differentiation, particularly in silencing lineage-specific genes. However, little is known about how LSD1 regulates neurosensory differentiation in the inner ear. Here we show that LSD1 interacts directly with the transcription factor Pax2 to form the NuRD co-repressor complex at the Pax2 target gene loci in a mouse otic neuronal progenitor cell line (VOT-N33). VOT-N33 cells expressing a Pax2-response element reporter were GFP-negative when untreated, but became GFP positive after forced differentiation or treatment with a potent LSD inhibitor. Pharmacological inhibition of LSD1 activity resulted in the enrichment of mono- and di-methylation of H3K4, upregulation of sensory neuronal genes and an increase in the number of sensory neurons in mouse inner ear organoids. Together, these results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear