Probing Feedback in Galaxy Formation with Millimeter-wave Observations

Achieving a precise understanding of galaxy formation in a cosmological context is one of the great challenges in theoretical astrophysics, due to the vast range of spatial scales involved in the relevant physical processes. Observations in the millimeter bands, particularly those using the cosmic microwave background (CMB) radiation as a "backlight", provide a unique probe of the thermodynamics of these processes, with the capability to directly measure the density, pressure, and temperature of ionized gas. Moreover, these observations have uniquely high sensitivity into the outskirts of the halos of galaxies and clusters, including systems at high redshift. In the next decade, the combination of large spectroscopic and photometric optical galaxy surveys and wide-field, low-noise CMB surveys will transform our understanding of galaxy formation via these probes.Comment: Submitted to the Astro2020 Decadal Surve

Lyman-Alpha-Emitting Galaxies at z = 2.1 in ECDF-S: Building Blocks of Typical Present-day Galaxies?

We discovered a sample of 250 Ly-Alpha emitting (LAE) galaxies at z=2.1 in an ultra-deep 3727 A narrow-band MUSYC image of the Extended Chandra Deep Field-South. LAEs were selected to have rest-frame equivalent widths (EW) > 20 A and emission line fluxes > 2.0 x 10^(-17)erg /cm^2/s, after carefully subtracting the continuum contributions from narrow band photometry. The median flux of our sample is 4.2 x 10^(-17)erg/cm^2/s, corresponding to a median Lya luminosity = 1.3 x 10^(42) erg/s at z=2.1. At this flux our sample is > 90% complete. Approximately 4% of the original NB-selected candidates were detected in X-rays by Chandra, and 7% were detected in the rest-frame far-UV by GALEX. At luminosity>1.3 x 10^42 erg/s, the equivalent width distribution is unbiased and is represented by an exponential with scale-length of 83+/-10 A. Above this same luminosity threshold, we find a number density of 1.5+/-0.5 x 10^-3 Mpc^-3. Neither the number density of LAEs nor the scale-length of their EW distribution show significant evolution from z=3 to z=2. We used the rest frame UV luminosity to estimate a median star formation rate of 4 M_(sun) /yr. The median rest frame UV slope, parametrized by B-R, is that typical of dust-free, 0.5-1 Gyr old or moderately dusty, 300-500 Myr old populations. Approximately 40% of the sample occupies the z~2 star-forming galaxy locus in the UVR two color diagram. Clustering analysis reveals that LAEs at z=2.1 have r_0=4.8+/-0.9 Mpc and a bias factor b=1.8+/-0.3. This implies that z=2.1 LAEs reside in dark matter halos with median masses Log(M/M_(sun))=11.5^(+0.4)_(-0.5), which are among of the lowest-mass halos yet probed at this redshift. We used the Sheth-Tormen conditional mass function to study the descendants of these LAEs and found that their typical present-day descendants are local galaxies with L* properties, like the Milky Way.Comment: 35 pages, 9 figures, ApJ, in pres

Keck-I MOSFIRE Spectroscopy of Compact Star-Forming Galaxies at \u3cem\u3ez\u3c/em\u3e ≳ 2: High Velocity Dispersions in Progenitors of Compact Quiescent Galaxies

We present Keck-I MOSFIRE near-infrared spectroscopy for a sample of 13 compact star-forming galaxies (SFGs) at redshift 2 ≤ z ≤ 2.5 with star formation rates of SFR ~ 100 M ☉ yr–1 and masses of log(M/M ☉) ~10.8. . . . For the remainder of the abstract, please visit: http://dx.doi.org/10.1088/0004-637X/795/2/14

What Triggers Oxygen Loss in Oxygen Redox Cathode Materials?

It is possible to increase the charge capacity of transition-metal (TM) oxide cathodes in alkali-ion batteries by invoking redox reactions on the oxygen. However, oxygen loss often occurs. To explore what affects oxygen loss in oxygen redox materials, we have compared two analogous Na-ion cathodes, P2-Na0.67Mg0.28Mn0.72O2 and P2-Na0.78Li0.25Mn0.75O2. On charging to 4.5 V, >0.4e– are removed from the oxide ions of these materials, but neither compound exhibits oxygen loss. Li is retained in P2-Na0.78Li0.25Mn0.75O2 but displaced from the TM to the alkali metal layers, showing that vacancies in the TM layers, which also occur in other oxygen redox compounds that exhibit oxygen loss such as Li[Li0.2Ni0.2Mn0.6]O2, are not a trigger for oxygen loss. On charging at 5 V, P2-Na0.78Li0.25Mn0.75O2 exhibits oxygen loss, whereas P2-Na0.67Mg0.28Mn0.72O2 does not. Under these conditions, both Na+ and Li+ are removed from P2-Na0.78Li0.25Mn0.75O2, resulting in underbonded oxygen (fewer than 3 cations coordinating oxygen) and surface-localized O loss. In contrast, for P2-Na0.67Mg0.28Mn0.72O2, oxygen remains coordinated by at least 2 Mn4+ and 1 Mg2+ ions, stabilizing the oxygen and avoiding oxygen loss

Clustering of Low-Redshift (z <= 2.2) Quasars from the Sloan Digital Sky Survey

We present measurements of the quasar two-point correlation function, \xi_{Q}, over the redshift range z=0.3-2.2 based upon data from the SDSS. Using a homogeneous sample of 30,239 quasars with spectroscopic redshifts from the DR5 Quasar Catalogue, our study represents the largest sample used for this type of investigation to date. With this redshift range and an areal coverage of approx 4,000 deg^2, we sample over 25 h^-3 Gpc^3 (comoving) assuming the current LCDM cosmology. Over this redshift range, we find that the redshift-space correlation function, xi(s), is adequately fit by a single power-law, with s_{0}=5.95+/-0.45 h^-1 Mpc and \gamma_{s}=1.16+0.11-0.16 when fit over s=1-25 h^-1 Mpc. Using the projected correlation function we calculate the real-space correlation length, r_{0}=5.45+0.35-0.45 h^-1 Mpc and \gamma=1.90+0.04-0.03, over scales of rp=1-130 h^-1 Mpc. Dividing the sample into redshift slices, we find very little, if any, evidence for the evolution of quasar clustering, with the redshift-space correlation length staying roughly constant at s_{0} ~ 6-7 h^-1 Mpc at z<2.2 (and only increasing at redshifts greater than this). Comparing our clustering measurements to those reported for X-ray selected AGN at z=0.5-1, we find reasonable agreement in some cases but significantly lower correlation lengths in others. We find that the linear bias evolves from b~1.4 at z=0.5 to b~3 at z=2.2, with b(z=1.27)=2.06+/-0.03 for the full sample. We compare our data to analytical models and infer that quasars inhabit dark matter haloes of constant mass M ~2 x 10^12 h^-1 M_Sol from redshifts z~2.5 (the peak of quasar activity) to z~0. [ABRIDGED]Comment: 28 pages, 26 figures, ApJ accepted. Online materials (including source code, catalogues and high-resolution figures) can be found at http://www.astro.psu.edu/users/npr/DR5

Clinical course, characteristics and prognostic indicators in patients presenting with back and leg pain in primary care. The ATLAS study protocol

Low-back related leg pain with or without nerve root involvement is associated with a poor prognosis compared to low back pain (LBP) alone. Compared to the literature investigating prognostic indicators of outcome for LBP, there is limited evidence on prognostic factors for low back-related leg pain including the group with nerve root pain. This 1 year prospective consultation-based observational cohort study will describe the clinical, imaging, demographic characteristics and health economic outcomes for the whole cohort, will investigate differences and identify prognostic indicators of outcome (i.e. change in disability at 12 months), for the whole cohort and, separately, for those classified with and without nerve root pain. In addition, nested qualitative studies will provide insights on the clinical consultation and the impact of diagnosis and treatment on patients' symptom management and illness trajectory

Experiment for cryogenic large-aperture intensity mapping: instrument design

The experiment for cryogenic large-aperture intensity mapping (EXCLAIM) is a balloon-borne telescope designed to survey star formation in windows from the present to z  =  3.5. During this time, the rate of star formation dropped dramatically, while dark matter continued to cluster. EXCLAIM maps the redshifted emission of singly ionized carbon lines and carbon monoxide using intensity mapping, which permits a blind and complete survey of emitting gas through statistics of cumulative brightness fluctuations. EXCLAIM achieves high sensitivity using a cryogenic telescope coupled to six integrated spectrometers employing kinetic inductance detectors covering 420 to 540 GHz with spectral resolving power R  =  512 and angular resolution ≈4  arc min. The spectral resolving power and cryogenic telescope allow the survey to access dark windows in the spectrum of emission from the upper atmosphere. EXCLAIM will survey 305  deg2 in the Sloan Digital Sky Survey Stripe 82 field from a conventional balloon flight in 2023. EXCLAIM will also map several galactic fields to study carbon monoxide and neutral carbon emission as tracers of molecular gas. We summarize the design phase of the mission

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707